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Injection","sponsorNew":"Replimune \/ Inapplicable","highestDevelopmentStatusID":"9","companyTruncated":"Replimune \/ Inapplicable"},{"orgOrder":0,"company":"Bristol Myers Squibb","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"Nivolumab","moa":"||PD-1","graph1":"Oncology","graph2":"Approved FDF","graph3":"Bristol Myers Squibb","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Bristol Myers Squibb \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Bristol Myers Squibb \/ Inapplicable"},{"orgOrder":0,"company":"Aulos","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"Aldesleukin","moa":"||CD25","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Aulos","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Aulos \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Aulos \/ Inapplicable"},{"orgOrder":0,"company":"Shanghai Henlius Biotech","sponsor":"Sandoz B2B","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody","year":"2025","type":"Licensing Agreement","leadProduct":"Ipilimumab","moa":"||CTLA-4","graph1":"Oncology","graph2":"Phase III","graph3":"Shanghai Henlius Biotech","amount2":0.29999999999999999,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0.29999999999999999,"dosageForm":"Intravenous Injection","sponsorNew":"Shanghai Henlius Biotech \/ Sandoz B2B","highestDevelopmentStatusID":"10","companyTruncated":"Shanghai Henlius Biotech \/ Sandoz B2B"}]

Find Clinical Drug Pipeline Developments & Deals for Nivolumab

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : XB002,Nivolumab

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Exelixis

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Details : Through the agreement, Novosep will perform the process development of the XB002 ADC. which is being evaluated in the early-stage clinical trial studies for the treatment of non-small cell lung cancer and cervical cancer.

                          Product Name : XB002

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Undisclosed

                          July 07, 2021

                          Lead Product(s) : XB002,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Exelixis

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Axplora CB

                          02

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : Under the terms of the agreement, Sandoz has exclusive commercial rights for Hepatocellular Carcinoma biosimilar drug HLX13 (ipilimumab) in Australia, Canada, Europe, Japan and the US.

                          Product Name : HLX13

                          Product Type : Antibody

                          Upfront Cash : $31.0 million

                          April 29, 2025

                          Lead Product(s) : Ipilimumab,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Sandoz B2B

                          Deal Size : $301.0 million

                          Deal Type : Licensing Agreement

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                          03

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : AU-007 is a human IgG1 mAb designed to harness the power of interleukin-2 (IL-2) to eradicate solid tumors. It is being evaluated for the treatment of melonoma with nivolumab and aldesleukin.

                          Product Name : AU-007

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          April 14, 2025

                          Lead Product(s) : AU-007,Aldesleukin,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : Opdivo (nivolumab) a PD-1 inihibitor in combination with chemotherapy is indicated for the treatment of adult patients with resectable non-small cell lung cancer.

                          Product Name : Opdivo

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 28, 2025

                          Lead Product(s) : Nivolumab,Cisplatin,Gemcitabine

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : Opdivo Qvantig (nivolumab & hyaluronidase) subcutaneous version PD-1 inhibitor is indicated for the treatment of carcinoma, renal cell.

                          Product Name : Opdivo Qvantig

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 28, 2025

                          Lead Product(s) : Nivolumab,Hyaluronidase

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : Combination of Opdivo (nivolumab) and Yervoy(Ipilimumab) is approved and indicated as an initial treatment for patients with advanced hepatocellular carcinoma.

                          Product Name : Opdivo

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 07, 2025

                          Lead Product(s) : Nivolumab,Ipilimumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : TJ033721 (givastomig) is a potential best-in-class, Claudin 18.2 (CLDN18.2) x 4-1BB bispecific antibody, targeting CLDN18.2-positive tumor cells.

                          Product Name : TJ033721

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 07, 2025

                          Lead Product(s) : Givastomig,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : ABL Bio

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : Combination of Opdivo (nivolumab) and Yervoy(Ipilimumab) met the main goal of a late-stage study evaluating it as an initial treatment for patients with advanced hepatocellular carcinoma.

                          Product Name : Opdivo

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 31, 2025

                          Lead Product(s) : Nivolumab,Ipilimumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : The collaboration evolves into ongoing research programs, including multiple T-cell engagers. The anti-CTLA-4 Probody BMS-986288 will not be advanced further following BMS’s internal portfolio review.

                          Product Name : BMS-986288

                          Product Type : Other Large Molecule

                          Upfront Cash : $200.0 million

                          December 03, 2024

                          Lead Product(s) : BMS-986288,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Bristol Myers Squibb

                          Deal Size : $2,000.0 million

                          Deal Type : Collaboration

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                          10

                          Iran Expo
                          Not Confirmed
                          Iran Expo
                          Not Confirmed

                          Details : Barinthus lead product VTP-300 (ChAdOx1-HBV) vaccine is being evaluated in mid-stage clinical trial studies in combination with Nivolumab for treating adults with chronic hepatitis B.

                          Product Name : VTP-300

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          November 15, 2024

                          Lead Product(s) : VTP-300,Nivolumab

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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