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Pipeline","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I\/ Phase II"}]

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            NDI-101150, a small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1) which is under phase 1/2 clinical development for the treatment of solid tumors.

            Lead Product(s): NDI-101150

            Therapeutic Area: Oncology Product Name: NDI-101150

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 05, 2024

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            Under the collaboration, Anagenex and Nimbus will discover small molecule drugs for multiple challenging targets by applying Anagenex’s AI driven parallel biochemistry platform to generate experimentally measured datapoints for each of Nimbus’ nominated targets.

            Lead Product(s): Undisclosed

            Therapeutic Area: Technology Product Name: Undisclosed

            Highest Development Status: Discovery Product Type: Small molecule

            Recipient: Anagenex

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration December 18, 2023

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            Nimbus will use financing to continue the ongoing clinical development of NDI-101150, a hematopoietic progenitor kinase 1 (HPK1) inhibitor, in patients with solid tumors.

            Lead Product(s): NDI-101150

            Therapeutic Area: Oncology Product Name: NDI-101150

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Google Ventures

            Deal Size: $210.0 million Upfront Cash: Undisclosed

            Deal Type: Private Placement September 06, 2023

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            Following the completion of this transaction, Takeda has now acquired TAK-279, formerly known at Nimbus as NDI-034858. This acquisition strengthens Takeda’s growing late-stage pipeline and potentially expands its portfolio and patient impact across multiple indications.

            Lead Product(s): NDI-034858

            Therapeutic Area: Immunology Product Name: TAK-279

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Takeda Pharmaceutical

            Deal Size: $6,000.0 million Upfront Cash: $4,000.0 million

            Deal Type: Agreement February 08, 2023

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            The acquisition strengthens Takeda's autoimmune portfolio, preferably NDI-034858 candidate, an oral, selective allosteric TYK2 inhibitor being evaluated for the treatment of multiple autoimmune diseases, especilally moderate to severe plaque psoriasis.

            Lead Product(s): NDI-034858

            Therapeutic Area: Immunology Product Name: NDI-034858

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Takeda Pharmaceutical

            Deal Size: $6,000.0 million Upfront Cash: $4,000.0 million

            Deal Type: Acquisition December 13, 2022

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            NDI-034858 is an allosteric TYK2 inhibitor developed by Nimbus Therapeutics that is being evaluated for the treatment of multiple autoimmune diseases. In preclinical studies, NDI-034858 has demonstrated exceptional functional selectivity and wide therapeutic margins.

            Lead Product(s): NDI-034858

            Therapeutic Area: Dermatology Product Name: NDI-034858

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 30, 2022

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            Nimbus’s computational drug discovery engine and expertise in structure-based drug design, Nimbus is uniquely positioned to develop isoform-selective small molecule activators of AMPK with potential therapeutic application to a broad range of metabolic disorders.

            Lead Product(s): Undisclosed

            Therapeutic Area: Genetic Disease Product Name: Undisclosed

            Highest Development Status: Discovery Product Type: Small molecule

            Partner/Sponsor/Collaborator: Eli Lilly

            Deal Size: $496.0 million Upfront Cash: Undisclosed

            Deal Type: Collaboration October 11, 2022

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            In a Phase 1 clinical study, NDI-034858 demonstrated a good tolerability profile and evidence of clinical and pharmacodynamic activity across multiple measures of disease pathology in psoriasis.

            Lead Product(s): NDI-034858

            Therapeutic Area: Dermatology Product Name: NDI-034858

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 24, 2022

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            The pharmacokinetic profile of NDI-034858 observed in healthy volunteers supports the potential for once-daily dosing, with 50 mg expected to cover IC90 for 24 hours.

            Lead Product(s): NDI-034858

            Therapeutic Area: Dermatology Product Name: NDI-034858

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 19, 2022

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            NTX-801, a Casitas B-lineage lymphoma b inhibitor demonstrated strong immune cell activation and robust and statistically significant tumor growth inhibition in a mouse syngeneic tumor model.

            Lead Product(s): NTX-801

            Therapeutic Area: Oncology Product Name: NTX-801

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 08, 2022

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