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Find Neurology Drugs in Phase II Clinical Development in SWITZERLAND

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            Lead Product(s): NRD135S.E1

            Therapeutic Area: Neurology Product Name: NRD.E1

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: GEM Global Yield

            Deal Size: $50.0 million Upfront Cash: Undisclosed

            Deal Type: Agreement January 28, 2021

            Details:

            The proceeds from this financing will be used to progress the clinical development of Novaremed’s lead product, NRD135S.E1, an investigational non-opioid small molecule drug for the treatment of painful diabetic peripheral neuropathy (PDPN).

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            Lead Product(s): ADX71149

            Therapeutic Area: Neurology Product Name: ADX71149

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Johnson & Johnson

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 21, 2021

            Details:

            The multi-center study will assess the efficacy, safety, tolerability and pharmacokinetics of adjunctive JNJ-40411813 (ADX71149) administration in patients with focal onset seizures with suboptimal response to levetiracetam.

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            Lead Product(s): Dipraglurant

            Therapeutic Area: Neurology Product Name: ADX48621

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: H.C. Wainwright & Co

            Deal Size: $11.5 million Upfront Cash: Undisclosed

            Deal Type: Public Offering January 11, 2021

            Details:

            Addex intends to use the net proceeds from the global offering, mainly to advance development of its portfolio of proprietary drug candidates based on its allosteric modulator development capabilities. These include dipraglurant for use in Parkinson's disease and dystonia.

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            Lead Product(s): NRD135S.E1

            Therapeutic Area: Neurology Product Name: NRD135S.E1

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 18, 2020

            Details:

            In a Phase 2a Proof of Concept study, NRD135S.E1 showed clinically relevant reduction in patient-reported pain and an excellent safety and tolerability profile. Novaremed Ltd is currently preparing to conduct a Phase 2b study in PDPN patients in USA.

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            Lead Product(s): NOE-101

            Therapeutic Area: Neurology Product Name: NOE-101

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Sofinnova Partners

            Deal Size: $59.0 million Upfront Cash: Undisclosed

            Deal Type: Series A Financing December 01, 2020

            Details:

            Financing will advance the development of four clinical-stage product candidates including lead product NOE-101. The product candidates will be developed in neurological indications with severe unmet need.

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            Lead Product(s): Semorinemab

            Therapeutic Area: Neurology Product Name: RG6100

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 23, 2020

            Details:

            In a Phase 2 trial of the anti-Tau antibody, semorinemab, in early (prodromal to mild) Alzheimer’s disease (AD) which show that semorinemab did not meet its primary efficacy endpoint of reducing decline on Clinical Dementia Rating-Sum of Boxes (CDR-SB) compared to placebo.

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            Lead Product(s): ADX71149

            Therapeutic Area: Neurology Product Name: JNJ-40411813

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 16, 2020

            Details:

            The multi-center study will assess the efficacy, safety, tolerability and pharmacokinetics of adjunctive JNJ-40411813 (ADX71149) administration in patients with focal onset seizures with suboptimal response to levetiracetam.

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            Lead Product(s): NRD135S.E1

            Therapeutic Area: Neurology Product Name: Undisclosed

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 25, 2020

            Details:

            The Phase 2 study, designed as a randomized, double-blind, placebo-controlled study, will enroll patients with neuropathic pain caused by Diabetes Mellitus. Eligible patients will be randomized to receive oral doses of either NRD135S.E1 or placebo once daily for 3 months.

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            Lead Product(s): Temelimab

            Therapeutic Area: Neurology Product Name: Undisclosed

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Bryan, Garnier & Co

            Deal Size: $19.3 million Upfront Cash: Undisclosed

            Deal Type: Investment January 31, 2020

            Details:

            Successfully completing this private placement provides GeNeuro the means to complete the planned study of temelimab in multiple sclerosis patients with disability progression without relapses.