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BIOTECH","amount2":0.02,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0.02,"dosageForm":"Intravenous Injection","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"15","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"Genmab","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"DENMARK","productType":"Antibody","year":"2020","type":"Collaboration","leadProduct":"Daratumumab","moa":"Lymphocyte differentiation antigen CD38","graph1":"Oncology","graph2":"Approved FDF","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"15","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"Legend Biotech","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2022","type":"Collaboration","leadProduct":"Ciltacabtagene Autoleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"JANSSEN BIOTECH","amount2":0.65000000000000002,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0.65000000000000002,"dosageForm":"Intravenous Infusion","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"15","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"XOMA","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2021","type":"Agreement","leadProduct":"Cetrelimab","moa":"||Programmed cell death protein 1","graph1":"Oncology","graph2":"Phase III","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"10","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"Cellular Biomedicine Group","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2023","type":"Collaboration","leadProduct":"Prizloncabtagene Autoleucel","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"JANSSEN BIOTECH","amount2":0.25,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.25,"dosageForm":"Intravenous Infusion","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"7","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"LegoChem Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"SOUTH KOREA","productType":"Other Large Molecule","year":"2023","type":"Licensing Agreement","leadProduct":"LCB84","moa":"||Trop2","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"JANSSEN BIOTECH","amount2":1.7,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":1.7,"dosageForm":"Intravenous Infusion","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"7","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"Moksha8 Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Controlled Substance","year":"2020","type":"Agreement","leadProduct":"Methylphenidate","moa":"Norepinephrine transporter | Dopamine transporter","graph1":"Psychiatry\/Psychology","graph2":"Approved FDF","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"15","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"Foundation Medicine","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2024","type":"Inapplicable","leadProduct":"Niraparib Tosylate","moa":"||Poly [ADP-ribose] polymerase-1 | Poly [ADP-ribose] polymerase 2","graph1":"Oncology","graph2":"Approved FDF","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"15","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"Idorsia Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"SWITZERLAND","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Aprocitentan","moa":"Endothelin receptor, ET-A\/ET-B","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved FDF","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"15","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"Protagonist Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Protein","year":"2023","type":"Licensing Agreement","leadProduct":"Icotrokinra","moa":"IL23R","graph1":"Immunology","graph2":"Phase II","graph3":"JANSSEN 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BIOTECH","sponsor":"Genocea","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2022","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Discovery Platform","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"3","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"Biocytogen","pharmaFlowCategory":"D","therapeuticArea":"Technology","country":"CHINA","productType":"Undisclosed","year":"2023","type":"Licensing Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Technology","graph2":"Discovery Platform","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Technology","amount2New":0,"dosageForm":"Oral","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"3","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"SpringWorks Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Collaboration","leadProduct":"Nirogacestat HBr","moa":"||Gamma-secretase","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"7","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"Sonnet BioTherapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Protein","year":"2022","type":"Agreement","leadProduct":"SON-1010","moa":"IL-12 receptor","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"JANSSEN BIOTECH \/ Janssen Biotech","highestDevelopmentStatusID":"7","companyTruncated":"JANSSEN BIOTECH \/ Janssen Biotech"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"JANSSEN BIOTECH","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Guselkumab","moa":"Interleukin-23","graph1":"Dermatology","graph2":"Phase IV","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"JANSSEN BIOTECH \/ JANSSEN BIOTECH","highestDevelopmentStatusID":"11","companyTruncated":"JANSSEN BIOTECH \/ JANSSEN BIOTECH"},{"orgOrder":0,"company":"JANSSEN BIOTECH","sponsor":"JANSSEN BIOTECH","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"Daratumumab","moa":"Lymphocyte differentiation antigen CD38","graph1":"Undisclosed","graph2":"Phase II","graph3":"JANSSEN BIOTECH","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"JANSSEN BIOTECH \/ JANSSEN BIOTECH","highestDevelopmentStatusID":"8","companyTruncated":"JANSSEN BIOTECH \/ JANSSEN BIOTECH"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Under the terms of the agreement, Janssen will develop, manufacture, and commercialize CAR T-based cell therapy candidates with Simcha’s novel proprietary DR-18 for a set number of programs.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          August 01, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Simcha Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          02

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : The collaboration focuses on developing an at-home subcutaneous version of a lead oncology asset and up to four additional targets using Elektrofi's formulation technology.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $18.0 million

                          March 01, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Elektrofi

                          Deal Size : $793.0 million

                          Deal Type : Collaboration

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                          03

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Akeega (niraparib, abiraterone acetate) is a tablet works by inhibiting approved for BRCA-mutated mCRPC in adults. The FDA has approved FoundationOne Liquid CDx as its companion diagnostic.

                          Product Name : Akeega

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          January 07, 2024

                          Lead Product(s) : Niraparib Tosylate,Abiraterone Acetate,Prednisone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Recipient : Foundation Medicine

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Under the terms of the agreement, LCB will grant Janssen an exclusive, worldwide license for the development and commercialization of LCB84, a Trop2 directed ADC which is currently being investigated for advanced solid tumors.

                          Product Name : Undisclosed

                          Product Type : Other Large Molecule

                          Upfront Cash : $100.0 million

                          December 26, 2023

                          Lead Product(s) : LCB84,Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : LegoChem Biosciences

                          Deal Size : $1,700.0 million

                          Deal Type : Licensing Agreement

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                          05

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Under the Agreement, Janssen is conducting Phase 2b trial of JNJ-2113 (formerly known as PN-235), a first-in-class targeted oral peptide designed to selectively block the IL-23 receptor, in moderately to severely active ulcerative colitis.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : $50.0 million

                          December 13, 2023

                          Lead Product(s) : Icotrokinra

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase II

                          Recipient : Protagonist Therapeutics

                          Deal Size : $987.5 million

                          Deal Type : Licensing Agreement

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                          06

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Janssen will use Biocytogen’s proprietary RenLite® platform to discover, research, develop, manufacture and commercialize fully human antibody therapeutics with a common light chain and other biological therapeutics for an unlimited number of drug tar...

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          August 03, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Technology

                          Highest Development Status : Discovery

                          Recipient : Biocytogen

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          07

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Through the collaboration, Janssen enhances its portfolio in B-cell malignancies and strengthens its legacy in hematology, by including C-CAR039 (prizloncabtagene autoleucel), a novel bispecific CAR-T therapy targeting both CD19 and CD20 antigens for the...

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          February 05, 2023

                          Lead Product(s) : Prizloncabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Cellular Biomedicine Group

                          Deal Size : $245.0 million

                          Deal Type : Collaboration

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                          08

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : ACT-132577 (aprocitentan) is a dual endothelin receptor antagonist, which potently inhibits the binding of ET-1 to ETA and ETB receptors. It has a mechanism of action that is ideally suited for the pathophysiology of resistant hypertension.

                          Product Name : Tryvio

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 31, 2023

                          Lead Product(s) : Aprocitentan

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Recipient : Idorsia Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : The collaboration aims for the co-development and commercialization of JNJ-2113, a novel, first and only oral IL-23 receptor antagonist peptide, in patients with moderate-to-severe psoriasis.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : $50.0 million

                          January 11, 2023

                          Lead Product(s) : Icotrokinra

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Recipient : Protagonist Therapeutics

                          Deal Size : $990.0 million

                          Deal Type : Collaboration

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                          10

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Under the collaboration, Janssen has chosen a lead gamma-delta T-cell engager bispecific antibody candidate aimed at an undisclosed tumor-associated antigen for further development towards clinical settings for the treatment of cancer.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          January 06, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Lava Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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