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Diseases","country":"CANADA","productType":"Enzyme","year":"2022","type":"Collaboration","leadProduct":"DispersinB","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Kane Biotech","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Bio-film","sponsorNew":"Kane Biotech \/ University of Maryland","highestDevelopmentStatusID":"4","companyTruncated":"Kane Biotech \/ University of Maryland"},{"orgOrder":0,"company":"Tetra BioPharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"CANADA","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Onternabez","moa":"CB2 receptor","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Tetra BioPharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Injection","sponsorNew":"Tetra BioPharma \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Tetra BioPharma \/ Inapplicable"},{"orgOrder":0,"company":"Appili Therapeutics","sponsor":"Aditxt","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"CANADA","productType":"Vaccine","year":"2024","type":"Acquisition","leadProduct":"ATI-1701","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Appili Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Appili Therapeutics \/ Aditxt","highestDevelopmentStatusID":"4","companyTruncated":"Appili Therapeutics \/ Aditxt"},{"orgOrder":0,"company":"Appili Therapeutics","sponsor":"Aditxt","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious 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Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Appili Therapeutics \/ Bloom Burton Securities","highestDevelopmentStatusID":"4","companyTruncated":"Appili Therapeutics \/ Bloom Burton Securities"},{"orgOrder":0,"company":"Appili Therapeutics","sponsor":"Defense Threat Reduction Agency","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"CANADA","productType":"Vaccine","year":"2022","type":"Funding","leadProduct":"ATI-1701","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Appili Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Appili Therapeutics \/ Defense Threat Reduction Agency","highestDevelopmentStatusID":"4","companyTruncated":"Appili Therapeutics \/ Defense Threat Reduction Agency"},{"orgOrder":0,"company":"Appili Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"CANADA","productType":"Vaccine","year":"2020","type":"Inapplicable","leadProduct":"ATI-1701","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Appili Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Appili Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Appili Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Appili Therapeutics","sponsor":"US Air Force Academy","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"CANADA","productType":"Vaccine","year":"2023","type":"Funding","leadProduct":"ATI-1701","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Appili Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Appili Therapeutics \/ US Air Force Academy","highestDevelopmentStatusID":"4","companyTruncated":"Appili Therapeutics \/ US Air Force Academy"},{"orgOrder":0,"company":"Appili Therapeutics","sponsor":"US Department of Defense","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"CANADA","productType":"Vaccine","year":"2022","type":"Funding","leadProduct":"ATI-1701","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Appili Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Appili Therapeutics \/ US Department of Defense","highestDevelopmentStatusID":"4","companyTruncated":"Appili Therapeutics \/ US Department of Defense"},{"orgOrder":0,"company":"Appili Therapeutics","sponsor":"USAFA","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"CANADA","productType":"Vaccine","year":"2023","type":"Funding","leadProduct":"ATI-1701","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Appili Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Appili Therapeutics \/ USAFA","highestDevelopmentStatusID":"4","companyTruncated":"Appili Therapeutics \/ USAFA"},{"orgOrder":0,"company":"Appili Therapeutics","sponsor":"Aditxt","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"CANADA","productType":"Vaccine","year":"2025","type":"Termination","leadProduct":"ATI-1701","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Appili Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Appili Therapeutics \/ Aditxt","highestDevelopmentStatusID":"4","companyTruncated":"Appili Therapeutics \/ Aditxt"}]

Find Drugs for Infections and Infectious Diseases in Preclinical Development in CANADA

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : The termination allows Appili to refocus on advancing its pipeline of anti-infectives, including ATI-1701, a next-generation LA vaccine with a targeted, well-characterized mechanism of attenuation.

                          Product Name : ATI-1701

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          May 30, 2025

                          Lead Product(s) : ATI-1701

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Aditxt

                          Deal Size : $1.2 million

                          Deal Type : Termination

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                          02

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : Zymeworks provided GSK access to its unique heavy-light chain pairing technology under the Azymetric™ platform for the development of bispecific and multifunctional therapeutics.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          February 26, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : GSK

                          Deal Size : $1,100.0 million

                          Deal Type : Expanded Collaboration

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                          03

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : Ruvidar (TLD-1433) is a ruthenium-based photodynamic compound. It is under development for the treatment of patients with herpes simplex virus, type 1 infection.

                          Product Name : Ruvidar

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 12, 2025

                          Lead Product(s) : TLD-1433

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : Aditxt will acquire Appili along with its pipeline, which includes the ATI-1701 vaccine. Currently, the vaccine is undergoing evaluation in preclinical trials for the treatment of tularemia.

                          Product Name : ATI-1701

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          July 25, 2024

                          Lead Product(s) : ATI-1701

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Aditxt

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          05

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : The company intends to use the net proceeds of the offering for clinical development of Bucillamine, which is an antirheumatic agent developed from tiopronin for the treatment of long-term COVID-19.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 26, 2024

                          Lead Product(s) : Bucillamine

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Hampton Securities Limited

                          Deal Size : $2.1 million

                          Deal Type : Private Placement

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                          06

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : Aditxt will acquire Appili and its pipeline, including ATI-1701, a vaccine in preclinical trials for tularemia treatment.

                          Product Name : ATI-1701

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          February 04, 2024

                          Lead Product(s) : ATI-1701

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Aditxt

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          07

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : The funding aims to support Radiant to develop the next generation of HIV biologics based on Radiant’s Multabody platform, which can destroy latent stores of the HIV virus, along with its ability to eliminate circulating viral particles.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          December 20, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Bill & Melinda Gates Foundation

                          Deal Size : $2.0 million

                          Deal Type : Funding

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                          08

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : The funding will be used to advance the ATI-1701, potential first-in-class vaccine candidate for the prevention of infection with Francisella tularensis, program toward an IND submission.

                          Product Name : ATI-1701

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          October 25, 2023

                          Lead Product(s) : ATI-1701

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : USAFA

                          Deal Size : $14.0 million

                          Deal Type : Funding

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                          09

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : AnQlar (quaternary ammonium palmitoyl glycol chitosan) is a nanoparticle intended to prevent the spread of negatively charged viruse such as COVID-19 and influenza via intranasal spray, and has shown to inhibit the ability of the virus to replicate at no...

                          Product Name : AnQlar

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          September 21, 2023

                          Lead Product(s) : Quaternary Ammonium Palmitoyl Glycol Chitosan

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Virpax Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : The funding will be used to advance Appili’s Biodefense Vaccine Candidate ATI-1701 to IND. ATI-1701 is a potential first-in-class vaccine candidate for the prevention of infection with Francisella tularensis, the causative agent of tularemia and a top-...

                          Product Name : ATI-1701

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          August 05, 2023

                          Lead Product(s) : ATI-1701

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : US Air Force Academy

                          Deal Size : $14.0 million

                          Deal Type : Funding

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