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BioPharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Hillstream BioPharma \/ Sapien Biosciences","highestDevelopmentStatusID":"5","companyTruncated":"Hillstream BioPharma \/ Sapien Biosciences"},{"orgOrder":0,"company":"Hillstream BioPharma","sponsor":"Thinkequity","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Public Offering","leadProduct":"Salinomycin","moa":"Ferroptosis","graph1":"Oncology","graph2":"IND Enabling","graph3":"Hillstream BioPharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Hillstream BioPharma \/ Thinkequity","highestDevelopmentStatusID":"5","companyTruncated":"Hillstream BioPharma \/ Thinkequity"},{"orgOrder":0,"company":"Hillstream 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BioPharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Hillstream BioPharma \/ Dana-Farber Cancer Institute","highestDevelopmentStatusID":"5","companyTruncated":"Hillstream BioPharma \/ Dana-Farber Cancer Institute"},{"orgOrder":0,"company":"Hillstream BioPharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Salinomycin","moa":"Ferroptosis","graph1":"Oncology","graph2":"IND Enabling","graph3":"Hillstream BioPharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Hillstream BioPharma \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Hillstream BioPharma \/ Inapplicable"}]

Find Clinical Drug Pipeline Developments & Deals by Hillstream BioPharma

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          AMWC Asia-TDAC
                          Not Confirmed
                          AMWC Asia-TDAC
                          Not Confirmed

                          Details : HSB-1216, is a novel and potent inducer of a powerful mechanism involving iron-mediated cell death. It is an emerging new anti-cancer mechanism, resulting in iron mediated cell death (IMCD) of drug resistant cancers.

                          Product Name : HSB-1216

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 04, 2023

                          Lead Product(s) : Salinomycin

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AMWC Asia-TDAC
                          Not Confirmed
                          AMWC Asia-TDAC
                          Not Confirmed

                          Details : HSB-510 is a novel highly targeted bifunctional inhibitor encapsulated in quatramer with single digit nanomolar IC 50 against PI3-Kδ and HDAC6, which is also known to downregulate MYC, a highly pursued and yet undruggable cancer target.

                          Product Name : HSB-510

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 02, 2023

                          Lead Product(s) : HSB-510

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AMWC Asia-TDAC
                          Not Confirmed
                          AMWC Asia-TDAC
                          Not Confirmed

                          Details : The Company intends to use the net proceeds from the offering for the advancement of HSB-1216, a novel and potent inducer of a powerful mechanism involving iron-mediated cell death, and the development of other product candidates in the Company’s pipel...

                          Product Name : HSB-1216

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          April 27, 2023

                          Lead Product(s) : Salinomycin

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Thinkequity

                          Deal Size : $2.6 million

                          Deal Type : Public Offering

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                          04

                          AMWC Asia-TDAC
                          Not Confirmed
                          AMWC Asia-TDAC
                          Not Confirmed

                          Details : The Company intends to use the net proceeds for the advancement of its lead drug candidate HSB-1216, which targets ferroptosis, an emerging new anti-cancer mechanism, and the development of other product candidates in the Company’s pipeline.

                          Product Name : HSB-1216

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 05, 2023

                          Lead Product(s) : Salinomycin

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Thinkequity

                          Deal Size : $2.6 million

                          Deal Type : Public Offering

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                          05

                          AMWC Asia-TDAC
                          Not Confirmed
                          AMWC Asia-TDAC
                          Not Confirmed

                          Details : Dana-Farber has granted under an exclusive option agreement to Hillstream Biopharma Inc., to develop anti-MUC1-C antibodies to selectively deliver Hillstream’s Quatramer-based lead candidate HSB-1216 targeting CSC by the induction of ferroptosis.

                          Product Name : HSB-1216

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          January 31, 2023

                          Lead Product(s) : Salinomycin

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Dana-Farber Cancer Institute

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          06

                          AMWC Asia-TDAC
                          Not Confirmed
                          AMWC Asia-TDAC
                          Not Confirmed

                          Details : The net proceeds from the initial public offering will be used to advance the Company’s product candidate HSB-1216 through pre-clinical activities, completion of Phase 1 studies and manufacturing, to advance the Company’s candidate HSB-888 through pr...

                          Product Name : HSB-1216

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          November 01, 2022

                          Lead Product(s) : Salinomycin

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Thinkequity

                          Deal Size : $15.0 million

                          Deal Type : Public Offering

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                          07

                          AMWC Asia-TDAC
                          Not Confirmed
                          AMWC Asia-TDAC
                          Not Confirmed

                          Details : The active drug in HSB-1216 was found to be efficacious in a clinical pilot study in Germany in devastating cancers, including triple negative breast cancer and epithelial carcinomas. Hillstream intends to start a clinical study with HSB-1216 in 2022.

                          Product Name : HSB-1216

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 27, 2022

                          Lead Product(s) : Salinomycin,Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Sapien Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          08

                          AMWC Asia-TDAC
                          Not Confirmed
                          AMWC Asia-TDAC
                          Not Confirmed

                          Details : HSB-1216, novel ferroptosis inducer against solid tumors has been granted an Orphan Drug Designation for significant need for patients with devastating disease for the treatment of uveal melanoma by the US FDA.

                          Product Name : HSB-1216

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 16, 2022

                          Lead Product(s) : Salinomycin

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AMWC Asia-TDAC
                          Not Confirmed
                          AMWC Asia-TDAC
                          Not Confirmed

                          Details : HSB-1216, an IMCD modulator active moiety in clinical pilot study produced a 71% response rate and efficacy against devastating cancers, including TNBC and epithelial carcinomas also targets solid tumors as a ferroptosis-inducing agent.

                          Product Name : HSB-1216

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 03, 2022

                          Lead Product(s) : Salinomycin

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AMWC Asia-TDAC
                          Not Confirmed
                          AMWC Asia-TDAC
                          Not Confirmed

                          Details : By combining Quatramers with their long half-life coated with a PD-1 Picobody™ to create HSB-1940, Hillstream believes it could more efficiently target novel epitopes with greater binding affinity than approved biologics.

                          Product Name : HSB-1940

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          January 12, 2022

                          Lead Product(s) : HSB-1940

                          Therapeutic Area : Oncology

                          Highest Development Status : Undisclosed

                          Sponsor : Minotaur Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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