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    [{"orgOrder":0,"company":"Entrada Therapeutics","sponsor":"Wellington Management Company","pharmaFlowCategory":"D","amount":"$116.0 million","upfrontCash":"Undisclosed","newsHeadline":"Entrada Therapeutics Announces Closing of $116 Million Series B Financing","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"March 2021","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Preclinical"},{"orgOrder":0,"company":"Entrada Therapeutics","sponsor":"Goldman Sachs & Co. 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              Entrada Therapeutics

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              Entrada Therapeutics Announces Updates on ENTR-601-44 in Duchenne Muscular Dystrophy

              Details:

              ENTR-601-44, a proprietary Endosomal Escape Vehicle (EEV™)-conjugated phosphorodiamidate morpholino oligomer (PMO), is the lead product candidate within Entrada’s Duchenne muscular dystrophy franchise.

              Lead Product(s): ENTR-601-44

              Therapeutic Area: Genetic Disease Product Name: ENTR-601-44

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable November 22, 2023

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              Entrada Therapeutics

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              Entrada Therapeutics Announces First Participant Dosed in its Phase 1 Clinical Trial of ENTR-601-44 for the Potential Treatment of Duchenne Muscular Dystrophy

              Details:

              ENTR-601-44, a proprietary Endosomal Escape Vehicle (EEV™)-conjugated phosphorodiamidate morpholino oligomer (PMO), is the lead product candidate within its Duchenne franchise from Entrada’s growing pipeline of EEV-therapeutics.

              Lead Product(s): ENTR-601-44

              Therapeutic Area: Genetic Disease Product Name: ENTR-601-44

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable September 21, 2023

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              Entrada Therapeutics

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              Entrada Therapeutics Receives Authorization in the United Kingdom to Initiate Phase 1 Clinical Trial of ENTR-601-44 for the Potential Treatment of Duchenne Muscular Dystrop...

              Details:

              ENTR-601-44, a proprietary Endosomal Escape Vehicle (EEV™)-conjugated phosphorodiamidate morpholino oligomer (PMO), is the lead product candidate within its Duchenne franchise from Entrada’s growing pipeline of EEV-therapeutics.

              Lead Product(s): ENTR-601-44

              Therapeutic Area: Genetic Disease Product Name: ENTR-601-44

              Highest Development Status: IND Enabling Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable August 01, 2023

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              Entrada Therapeutics Closes Agreement with Vertex to Discover and Develop Endosomal Escape Vehicle-Therapeutics for Myotonic Dystrophy Type 1 (DM1)

              Details:

              The agreement includes a four-year global research collaboration whereby Entrada will continue to advance for certain research activities related to ENTR-701 (EEV-conjugated phosphorodiamidate morpholino oligomer), as well as additional DM1-related research activities.

              Lead Product(s): EEV-conjugated Phosphorodiamidate Morpholino Oligomer

              Therapeutic Area: Genetic Disease Product Name: ENTR-701

              Highest Development Status: Preclinical Product Type: Large molecule

              Partner/Sponsor/Collaborator: Vertex Pharmaceuticals

              Deal Size: $735.0 million Upfront Cash: $224.0 million

              Deal Type: Agreement February 09, 2023

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              Entrada Therapeutics

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              Entrada Therapeutics Announces Clinical Candidate, ENTR-601-45, for the Potential Treatment of People Living with Duchenne Muscular Dystrophy who are Exon 45 Skipping Amena...

              Details:

              ENTR-601-45 is a Endosomal Escape Vehicle-conjugated phosphorodiamidate morpholino oligomer, has the potential to restore the mRNA reading frame and allow for the translation of dystrophin protein, it Duchenne muscular dystrophy patients.

              Lead Product(s): ENTR-601-45

              Therapeutic Area: Genetic Disease Product Name: ENTR-601-45

              Highest Development Status: Preclinical Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 09, 2023

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              Entrada Therapeutics Announces Clinical Hold on IND Application for ENTR-601-44 in Duchenne Muscular Dystrophy

              Details:

              The Company’s lead oligonucleotide programs include ENTR-601-44 targeting Duchenne muscular dystrophy (DMD) and ENTR-701 targeting myotonic dystrophy type 1 (DM1).

              Lead Product(s): ENTR-601-44

              Therapeutic Area: Genetic Disease Product Name: ENTR-601-44

              Highest Development Status: IND Enabling Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable December 19, 2022

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              Vertex and Entrada Therapeutics Establish Collaboration to Discover and Develop Endosomal Escape Vehicle (EEV) Therapeutics for Myotonic Dystrophy Type 1 (DM1)

              Details:

              ENTR-701, a proprietary Endosomal Escape Vehicle (EEV™)-conjugated phosphorodiamidate morpholino oligomer, is the second novel clinical candidate from Entrada’s growing pipeline of EEV therapeutics.

              Lead Product(s): EEV-conjugated Phosphorodiamidate Morpholino Oligomer

              Therapeutic Area: Genetic Disease Product Name: ENTR-701

              Highest Development Status: Preclinical Product Type: Large molecule

              Partner/Sponsor/Collaborator: Vertex Pharmaceuticals

              Deal Size: $735.0 million Upfront Cash: $224.0 million

              Deal Type: Collaboration December 08, 2022

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              Entrada Therapeutics

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              Entrada Therapeutics Presents New Data Supporting its Growing Pipeline of Endosomal Escape Vehicle (EEV) Therapeutics at TIDES USA 2022

              Details:

              New non-human primate data demonstrate a durability of response through 12 weeks for lead clinical candidate, ENTR-601-44, for the potential treatment of Duchenne muscular dystrophy.

              Lead Product(s): ENTR-601-44

              Therapeutic Area: Genetic Disease Product Name: ENTR-601-44

              Highest Development Status: Preclinical Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable May 11, 2022

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              Entrada Therapeutics Announces Closing of Initial Public Offering

              Details:

              ENTR-601-44 (Exon 44 Skipping Oligonucleotide) is being developed for patients with DMD that are exon 44 skipping amenable. We plan to submit an Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) for ENTR-601-44 in 2022.

              Lead Product(s): ENTR-601-44

              Therapeutic Area: Genetic Disease Product Name: ENTR-601-44

              Highest Development Status: Preclinical Product Type: Large molecule

              Partner/Sponsor/Collaborator: Goldman Sachs & Co. LLC

              Deal Size: $181.5 million Upfront Cash: Undisclosed

              Deal Type: Public Offering November 02, 2021

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              Entrada Therapeutics Announces Closing of $116 Million Series B Financing

              Details:

              The Company plans to use the investment proceeds to advance its diverse pipeline to the clinic. Included in this pipeline are several of Entrada’s oligonucleotide programs for the treatment of multiple neuromuscular diseases, led by Duchenne muscular dystrophy (DMD).

              Lead Product(s): Oligonucleotide antibody

              Therapeutic Area: Genetic Disease Product Name: Undisclosed

              Highest Development Status: Preclinical Product Type: Large molecule

              Partner/Sponsor/Collaborator: Wellington Management Company

              Deal Size: $116.0 million Upfront Cash: Undisclosed

              Deal Type: Series B Financing March 31, 2021

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