Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : EN-374
Therapeutic Area : Genetic Disease
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Ensoma gets FDA IND Clearance for First In Vivo HSC Gene Insertion Therapy
Details : EN-374 is a first-in-class in vivo HSC-directed therapy for X-CGD, which is caused by mutations in the CYBB gene of the NAPDH oxidase complex in neutrophils.
Product Name : Undisclosed
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
May 12, 2025
Lead Product(s) : EN-374
Therapeutic Area : Genetic Disease
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : EN-374
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease
Details : Undisclosed
Product Name : Undisclosed
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
March 14, 2025
Lead Product(s) : EN-374
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : EN-374
Therapeutic Area : Genetic Disease
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Ensoma's EN-374 Gets Rare Pediatric, Orphan Drug Status for Granulomatous Disease
Details : EN-374 is a CD46/CYBB modulator, gene therapy candidate, which is currently being evaluated for the treatment of X-linked chronic granulomatous disease (X-CGD).
Product Name : Undisclosed
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
February 13, 2025
Lead Product(s) : EN-374
Therapeutic Area : Genetic Disease
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Discovery Platform
Recipient : Twelve Bio
Deal Size : Undisclosed
Deal Type : Acquisition
Ensoma Announces Closing of Twelve Bio Acquisition
Details : The company’s Engenious™ platform combines innovative delivery technology with the full DNA editing toolkit to tackle diseases that affect millions around the world, such as cancer and autoimmune disease, as well as inherited conditions.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
September 02, 2023
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Discovery Platform
Recipient : Twelve Bio
Deal Size : Undisclosed
Deal Type : Acquisition
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Kite Pharma
Deal Size : $135.0 million
Deal Type : Series B Financing
Ensoma Closes Series B Extension, Bringing Total Round to $135 Million
Details : The fundings will advance the development of Ensoma’s Engenious™ in vivo engineered cell therapy platform and pipeline of genomic medicines for immuno-oncology, genetic disease and other therapeutic applications.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
May 16, 2023
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Kite Pharma
Deal Size : $135.0 million
Deal Type : Series B Financing
Lead Product(s) : MGTA-145
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Bluebird Bio
Deal Size : Inapplicable
Deal Type : Inapplicable
Study of MGTA-145 and Plerixafor in Patients With Sickle Cell Disease
Details : Undisclosed
Product Name : Undisclosed
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
July 06, 2022
Lead Product(s) : MGTA-145
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Bluebird Bio
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Undisclosed
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Preclinical
Sponsor : 5Am Ventures
Deal Size : $70.0 million
Deal Type : Series A Financing
Details : Company’s Engenious™ vectors Delivered without Stem Cell Collection or Myeloablative Conditioning in Outpatient and Low-Resource Settings, Enabling Access Worldwide.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
November 02, 2021
Lead Product(s) : Undisclosed
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Preclinical
Sponsor : 5Am Ventures
Deal Size : $70.0 million
Deal Type : Series A Financing
Details : Undisclosed
Product Name : Undisclosed
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
February 21, 2021
Lead Product(s) : MGTA-145
Therapeutic Area : Nephrology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Undisclosed
Product Name : Undisclosed
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
November 06, 2019
Lead Product(s) : MGTA-145
Therapeutic Area : Nephrology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : MGTA-145
Therapeutic Area : Undisclosed
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Undisclosed
Product Name : Undisclosed
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
May 01, 2019
Lead Product(s) : MGTA-145
Therapeutic Area : Undisclosed
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable