Lead Product(s) : Pentagalloyl Glucose
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II/ Phase III
Sponsor : Norwest Venture Partners
Deal Size : $96.0 million
Deal Type : Series D Financing
Nectero Medical Announces Completion of $96M Series D Financing
Details : The net Proceeds will be utilized to accelerate the clinical advancement of the Nectero EAST (pentagalloyl glucose) for the treatment abdominal aortic aneurysms.
Product Name : Nectero EAST
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
November 04, 2024
Lead Product(s) : Pentagalloyl Glucose
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : Norwest Venture Partners
Deal Size : $96.0 million
Deal Type : Series D Financing
Lead Product(s) : Tecarfarin
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II/ Phase III
Sponsor : H.C. Wainwright & Co
Deal Size : $5.1 million
Deal Type : Financing
Cadrenal Therapeutics Raises $5.1 Million via At-The-Market Facility
Details : The net proceeds will be used in developing ATI-5923 (tecarfarin), a new vitamin K antagonist (VKA), prepare for our pivotal Phase 3 trial.
Product Name : ATI-5923
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
October 24, 2024
Lead Product(s) : Tecarfarin
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : H.C. Wainwright & Co
Deal Size : $5.1 million
Deal Type : Financing
Lead Product(s) : Aficamten
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Cytokinetics Starts CEDAR-HCM Trial for Pediatric Obstructive Hypertrophic Cardiomyopathy
Details : CK-3773274 (aficamten) is an investigational selective, small molecule cardiac myosin inhibitor. It is under clinical development for obstructive hypertrophic cardiomyopathy in pediatric population.
Product Name : CK-3773274
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 05, 2024
Lead Product(s) : Aficamten
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Rinvecalinase Alpha
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Undisclosed
Deal Type : Private Placement
DiaMedica Therapeutics Announces $11.8 Million Private Placement
Details : The net proceeds will be used to advance the clinical development of DM199 (rinvecalinase alfa) recombinant form of rhKLK1. It is being evaluated for the treatment of acute ischemic stroke.
Product Name : DM199
Product Type : Enzyme
Upfront Cash : Undisclosed
June 26, 2024
Lead Product(s) : Rinvecalinase Alpha
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Undisclosed
Deal Type : Private Placement
Lead Product(s) : Pentagalloyl Glucose
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Nectero Medical Initiates Phase II/III Trial Of Nectero EAST® System
Details : The Nectero EAST System delivers pentagalloyl glucose locally into aneurysmal walls for treating small- to medium-sized abdominal aortic aneurysms in Phase 2/3.
Product Name : Nectero EAST
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 18, 2024
Lead Product(s) : Pentagalloyl Glucose
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Tecarfarin,Warfarin Sodium
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II/ Phase III
Sponsor : The Sage Group
Deal Size : Undisclosed
Deal Type : Partnership
Details : Under the partnership, Sage Group will assist Cadrenal in exploring strategic partnerships, co-development and licensing agreements for ATI-5923 (tecarfarin), a late-stage, novel, oral and reversible anticoagulant designed to prevent heart attacks, strok...
Product Name : ATI-5923
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
December 12, 2023
Lead Product(s) : Tecarfarin,Warfarin Sodium
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : The Sage Group
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : Rinvecalinase Alpha
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II/ Phase III
Sponsor : Craig-Hallum Capital Group
Deal Size : $37.5 million
Deal Type : Private Placement
DiaMedica Therapeutics Announces Closing of $37.5 Million Private Placement
Details : The Company intends to use the net proceeds to continue its clinical and product development activities for DM199 (recombinant human tissue kallikrein), including its pivotal Phase 2/3, ReMEDy2 clinical trial to treat acute ischemic stroke patients.
Product Name : DM199
Product Type : Enzyme
Upfront Cash : Undisclosed
June 26, 2023
Lead Product(s) : Rinvecalinase Alpha
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : Craig-Hallum Capital Group
Deal Size : $37.5 million
Deal Type : Private Placement
Lead Product(s) : Rinvecalinase Alpha
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : DM199 is a recombinant human tissue kallikrein-1. KLK1 is a serine protease that plays an important role in the regulation of diverse physiological processes including blood flow, oxidative stress and neurogenesis, which is investigated for Ischemic Stro...
Product Name : DM199
Product Type : Enzyme
Upfront Cash : Inapplicable
June 21, 2023
Lead Product(s) : Rinvecalinase Alpha
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Rinvecalinase Alpha
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II/ Phase III
Sponsor : Craig-Hallum Capital Group
Deal Size : $37.5 million
Deal Type : Private Placement
DiaMedica Therapeutics Announces $37.5 Million Private Placement
Details : The Company intends to use the net proceeds to continue its clinical and product development activities for DM199 (recombinant human tissue kallikrein), including its pivotal Phase 2/3, ReMEDy2 clinical trial to treat acute ischemic stroke patients.
Product Name : DM199
Product Type : Enzyme
Upfront Cash : Undisclosed
June 21, 2023
Lead Product(s) : Rinvecalinase Alpha
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : Craig-Hallum Capital Group
Deal Size : $37.5 million
Deal Type : Private Placement
Lead Product(s) : Imatinib Mesylate
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : AV-101 is an investigational, proprietary dry powder inhaled formulation of the anti-proliferative drug imatinib. Developed specifically for PAH, AV-101 is designed for delivery by an easy-to-use dry powder inhaler, directly into the lungs.
Product Name : AV-101
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 17, 2022
Lead Product(s) : Imatinib Mesylate
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable