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    [{"orgOrder":0,"company":"Asher Biotherapeutics","sponsor":"AstraZeneca","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Protein","year":"2025","type":"Agreement","leadProduct":"Etakafusp Alpha","moa":"||CD8","graph1":"Oncology","graph2":"IND Enabling","graph3":"Asher Biotherapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Asher Biotherapeutics \/ AstraZeneca","highestDevelopmentStatusID":"5","companyTruncated":"Asher Biotherapeutics \/ AstraZeneca"},{"orgOrder":0,"company":"Asher Biotherapeutics","sponsor":"Amgen Inc","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Protein","year":"2025","type":"Collaboration","leadProduct":"Etakafusp Alpha","moa":"||CD8","graph1":"Oncology","graph2":"IND Enabling","graph3":"Asher 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    Find Clinical Drug Pipeline Developments & Deals by Asher Biotherapeutics

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                            01

                            Asher Biotherapeutics

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                            Asher Biotherapeutics

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                            Lead Product(s) : Etakafusp Alpha,Tarlatamab

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Amgen Inc

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Asher Bio, BeiGene Collaborate on AB248, T-Cell Engager for Lung Cancer

                            Details : As part of this collaboration agreement, Amgen will sponsor a global Phase 1b study to evaluate the early efficacy of AB248 (etakafusp alfa) in combination with Imdelltra in patients with ES-SCLC.

                            Product Name : AB248

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            January 08, 2025

                            Lead Product(s) : Etakafusp Alpha,Tarlatamab

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Amgen Inc

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            02

                            Asher Biotherapeutics

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                            BIO Asia-Taiwan
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                            Asher Biotherapeutics

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                            Lead Product(s) : Etakafusp Alpha,Rilvegostomig

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : AstraZeneca

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Asher Bio, BeiGene Collaborate on AB248 Phase 1b/2 NSCLC Clinical Trial

                            Details : As part of this agreement, AstraZeneca will operationalize a global study of AB248 (etakafusp alfa) as a first-line treatment in combination with rilvegostomig in patients with advanced NSCLC.

                            Product Name : AB248

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            January 07, 2025

                            Lead Product(s) : Etakafusp Alpha,Rilvegostomig

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : AstraZeneca

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            03

                            Asher Biotherapeutics

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                            Asher Biotherapeutics

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                            Lead Product(s) : Etakafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : RA Capital Management

                            Deal Size : $55.0 million

                            Deal Type : Series C Financing

                            DEALS_DEV arrow-down

                            Asher Bio Closes $55 Million Series C Financing for Trials

                            Details : AB248, a novel IL-2 mutein fused to anti-CD8β antibody, is in Phase 1 trials as a CD8+ T cell selective IL-2 for cancer treatment.

                            Product Name : AB248

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            April 16, 2024

                            Lead Product(s) : Etakafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : RA Capital Management

                            Deal Size : $55.0 million

                            Deal Type : Series C Financing

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                            04

                            Asher Biotherapeutics

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                            Asher Biotherapeutics

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                            Lead Product(s) : Etakafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Asher Bio Announces Dosing of First Patient in Phase 1a/1b Clinical Trial of AB248, a Cis-targeted IL-2 Immuno...

                            Details : AB248 is a novel CD8+ T cell selective IL-2, it selectively and potently activate CD8+ T-cells, while avoiding NK cells, which can act as pharmacological sink and contribute to toxicity, and regulatory T (Treg) cells, which are immunosuppressive.

                            Product Name : AB248

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            January 17, 2023

                            Lead Product(s) : Etakafusp Alpha,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Asher Biotherapeutics

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                            BIO Asia-Taiwan
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                            Asher Biotherapeutics

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                            Lead Product(s) : AB359

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Asher Bio to Present First Preclinical Data for AB359, its CD8-targeted IL-2 Immunotherapy for Hepatitis B at ...

                            Details : AB359, a CD8-targeted interleukin-2 (IL-2) immunotherapy for the treatment of chronic viral infections is potentially more tolerable and more active IL‑2-based therapy for the treatment of chronic HBV.

                            Product Name : AB359

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            October 21, 2022

                            Lead Product(s) : AB359

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Asher Biotherapeutics

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                            Asher Biotherapeutics

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                            Lead Product(s) : Etakafusp Alpha

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Asher Bio to Showcase Continued Progress with Lead Program AB248 and Growing Pipeline of Precisely-Targeted Im...

                            Details : New preclinical data highlight the differentiated efficacy and safety profile of AB248, a fusion protein that selectively activates the IL-2 pathway in CD8+ T cells, which are key drivers of anti-tumor efficacy.

                            Product Name : AB248

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            October 03, 2022

                            Lead Product(s) : Etakafusp Alpha

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Asher Biotherapeutics

                            U.S.A arrow
                            BIO Asia-Taiwan
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                            Asher Biotherapeutics

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                            Lead Product(s) : Etakafusp Alpha

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Asher Bio to Present New Preclinical Data Demonstrating Differentiated Profile of AB248, its Lead Cis-targeted...

                            Details : AB248 demonstrated selectivity, with an approximately 1000-fold preference for the activation of CD8+ T cells over NK cells and Tregs, and induced dose-dependent, selective expansion of CD8+ T cells in non-human primates.

                            Product Name : AB248

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            August 04, 2022

                            Lead Product(s) : Etakafusp Alpha

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Asher Biotherapeutics

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                            BIO Asia-Taiwan
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                            Asher Biotherapeutics

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                            Lead Product(s) : Etakafusp Alpha

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Asher Bio to Present New Preclinical Data for CD8+ T Cell Targeted Immunotherapies, AB248 and AB821, at SITC 2...

                            Details : AB248, Asher Bio’s lead cis-targeted immunotherapy, is a novel CD8-targeted IL-2 mutein designed to selectively activate interleukein-2 (IL-2) signaling on CD8+ T cells over natural killer cells and regulatory T (Treg) cells.

                            Product Name : AB248

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            May 10, 2022

                            Lead Product(s) : Etakafusp Alpha

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Asher Biotherapeutics

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                            BIO Asia-Taiwan
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                            Asher Biotherapeutics

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                            Lead Product(s) : AB359

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Recipient : Lonza Biologics Inc

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Lonza and Asher Biotherapeutics to Collaborate on Manufacturing AB359

                            Details : Under the manufacturing agreement, Lonza will provide drug substance manufacturing for AB359 for preclinical and clinical testing.

                            Product Name : AB359

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            April 07, 2022

                            Lead Product(s) : AB359

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Recipient : Lonza Biologics Inc

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            10

                            Asher Biotherapeutics

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                            BIO Asia-Taiwan
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                            Asher Biotherapeutics

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                            BIO Asia-Taiwan
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                            Lead Product(s) : AB821

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Asher Bio to Present New Preclinical Data for Selective Support of CAR-T Cell Therapies by Cis-Targeted IL-2 a...

                            Details : AB821, a CD8-IL21 cytokine has the potential to treat tumor types that may not be responsive to IL-2 and/or PD-1 therapy. PD-1-resistant tumors are associated with reduced memory T cell numbers and increased exhausted T cell numbers.

                            Product Name : AB821

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            March 11, 2022

                            Lead Product(s) : AB821

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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