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Announces Updated Phase 1 Data and Progress on BOT\/BAL Development in Metastatic MSS Colorectal Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II"}]
Find Clinical Drug Pipeline Developments & Deals by Agenus
AGEN1181 (botensilimab) a novel innate/adaptive immune activator, is a multifunctional Fc-enhanced anti-CTLA-4 which is given in combination with balstilimab (anti-PD-1) in patients with Metastatic Microsatellite stable colorectal cancer.
Under the agreement, Bristol licensed BMS-986442 (AGEN1777), a dual TIGIT and CD96 antagonist with an enhanced Fc region to improve tumor-reactive T cell responses, from Agenus and currently dosed first patient in the phase 2 of the ongoing clinical trial.
AGEN1181 (botensilimab) a novel innate/adaptive immune activator, is a multifunctional Fc-enhanced anti-CTLA-4 which is given in combination with balstilimab (anti-PD-1) in patients with chemotherapy and/or immunotherapy-resistant tumors.
AGEN1181 (botensilimab) a novel innate/adaptive immune activator, is a multifunctional Fc-enhanced anti-CTLA-4 which is given in combination with balstilimab (anti-PD-1) in patients with chemotherapy and/or immunotherapy-resistant tumors.
AGEN1181 (botensilimab) is a novel innate and adaptive immune activator that binds ctla-4 and has demonstrated activity in cancer patients. it has received fast track designation for colorectal cancer.
AGEN1181 (botensilimab) is a novel innate and adaptive immune activator that binds CTLA-4. The antibody was designed to enhance FcγR effector functions while avoiding complement-related toxicities and has demonstrated activity in cancer patients.
AGEN1181 (botensilimab) a novel innate/adaptive immune activator, is a multifunctional Fc-enhanced anti-CTLA-4 which is given in combination with balstilimab (anti-PD-1) in patients with chemotherapy and/or immunotherapy-resistant tumors.
AGEN1181 (botensilimab) is a next-generation, Fc-enhanced, immunoglobulin G1 (IgG1) antibody designed to block CTLA-4 (cytotoxic T-lymphocyte associated antigen 4) from interacting with its ligands CD80 and CD86.
AGEN1181 is an Fc-enhanced anti–CTLA-4 monoclonal antibody. The botensilimab/balstilimab combination produced superior responses and strong durability relative to what has been reported in separate trials for standard of care and other combinations currently in development.
AGEN1181 (botensilimab) is an Fc-enhanced anti–CTLA-4 monoclonal antibody. Botensilimab was well tolerated, with no new immune-mediated safety signals outside of those observed in the class.
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