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Atkins, MD"},{"orgOrder":0,"company":"Agenus","sponsor":"Nicholas DeVito, MD","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2024","type":"Inapplicable","leadProduct":"Botensilimab","moa":"monoclonal antibodies: immunomodulating","graph1":"Oncology","graph2":"Phase II","graph3":"Agenus","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Agenus \/ Nicholas DeVito, MD","highestDevelopmentStatusID":"8","companyTruncated":"Agenus \/ Nicholas DeVito, MD"},{"orgOrder":0,"company":"Agenus","sponsor":"Yuan Yuan","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"Ivermectin","moa":"Glutamate-gated chloride channel","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Agenus","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Agenus \/ Yuan Yuan","highestDevelopmentStatusID":"7","companyTruncated":"Agenus \/ Yuan Yuan"},{"orgOrder":0,"company":"Agenus","sponsor":"Bruno Bockorny","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2022","type":"Inapplicable","leadProduct":"AGEN1423","moa":"TGF-beta-1\/PD-L1","graph1":"Oncology","graph2":"Phase II","graph3":"Agenus","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Agenus \/ Bruno Bockorny","highestDevelopmentStatusID":"8","companyTruncated":"Agenus \/ Bruno Bockorny"}]

Find Clinical Drug Pipeline Developments & Deals by Agenus

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                          Therapeutic Area by Lead Product

                          Study Phase by Lead Product

                          Company by Lead Product

                          Top Deals by Deal Size (USD bn)

                          01

                          Neuroscience
                          Not Confirmed
                          Neuroscience
                          Not Confirmed

                          Details : Botensilimab is a Antibody drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Colorectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          August 18, 2025

                          Lead Product(s) : Botensilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Recipient : Massachusetts General Hospital

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Neuroscience
                          Not Confirmed
                          Neuroscience
                          Not Confirmed

                          Details : Agenus will also grant Zydus an exclusive license to develop and commercialize botensilimab and balstilimab (BOT/BAL) in India and Sri Lanka.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : $75.0 million

                          June 03, 2025

                          Lead Product(s) : Botensilimab,Balstilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Zydus Lifesciences

                          Deal Size : $141.0 million

                          Deal Type : Collaboration

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                          03

                          Neuroscience
                          Not Confirmed
                          Neuroscience
                          Not Confirmed

                          Details : Balstilimab is a Antibody drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Rectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          February 25, 2025

                          Lead Product(s) : Balstilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : Memorial Sloan Kettering Cancer Center

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Neuroscience
                          Not Confirmed
                          Neuroscience
                          Not Confirmed

                          Details : Botensilimab is a Antibody drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Carcinoma, Pancreatic Ductal.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          February 25, 2025

                          Lead Product(s) : Botensilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Benjamin Spieler

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Neuroscience
                          Not Confirmed
                          Neuroscience
                          Not Confirmed

                          Details : Evofosfamide is a Cytotoxic Drug drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Prostatic Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          January 20, 2025

                          Lead Product(s) : Evofosfamide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : ImmunoGenesis

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Neuroscience
                          Not Confirmed
                          Neuroscience
                          Not Confirmed

                          Details : Botensilimab is a Antibody drug candidate, which is currently being evaluated in clinical studies for the treatment of Colorectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          December 30, 2024

                          Lead Product(s) : Botensilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Neuroscience
                          Not Confirmed
                          Neuroscience
                          Not Confirmed

                          Details : The partnership aims to grant access to AGEN1181 (botensilimab) & balstilimab. This initiative, delivered via an NPP, offers treatment options for patients with MSS colorectal cancer.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          December 12, 2024

                          Lead Product(s) : Botensilimab,Balstilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Tanner Pharma

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          08

                          Neuroscience
                          Not Confirmed
                          Neuroscience
                          Not Confirmed

                          Details : AGEN1181 (botensilimab) a novel innate/adaptive immune activator, is a multifunctional Fc-enhanced anti-CTLA-4, given in combination with balstilimab in microsatellite stable colorectal cancer.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          July 18, 2024

                          Lead Product(s) : Botensilimab,Balstilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Neuroscience
                          Not Confirmed
                          Neuroscience
                          Not Confirmed

                          Details : AGEN1181 (botensilimab) a novel innate/adaptive immune activator, is a multifunctional Fc-enhanced anti-CTLA-4, given in combination with balstilimab in microsatellite stable colorectal cancer.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          May 16, 2024

                          Lead Product(s) : Botensilimab,Balstilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Neuroscience
                          Not Confirmed
                          Neuroscience
                          Not Confirmed

                          Details : Financing supports AGEN1181 and AGEN2034 Phase 3 for metastatic colorectal cancer without active liver metastases.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          May 07, 2024

                          Lead Product(s) : Botensilimab,Balstilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Ligand Pharmaceuticals

                          Deal Size : $100.0 million

                          Deal Type : Financing

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