
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Alumis
Deal Size : Undisclosed
Deal Type : Merger
Alumis Completes Merger with ACELYRIN
Details : Under the merger agreement, both companies will advance the developing and delivering transformative medicines such as ESK-001, which is being evaluated for the treatment of Psoriasis.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
May 21, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Alumis
Deal Size : Undisclosed
Deal Type : Merger

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Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Alumis
Deal Size : Undisclosed
Deal Type : Merger
Alumis and ACELYRIN Announce Amended Merger Agreement
Details : Under the merger agreement, both companies will advance the developing and delivering transformative medicines such as ESK-001, which is being evaluated for the treatment of Psoriasis.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
April 21, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Alumis
Deal Size : Undisclosed
Deal Type : Merger

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Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Alumis
Deal Size : Undisclosed
Deal Type : Merger
Alumis, ACELYRIN Merge to Develop Immune Disease Therapies
Details : Under the merger agreement, Both companies will advance the developing and delivering transformative medicines such as ESK-001, which is being evaluated for the treatment of Psoriasis.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
February 06, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Alumis
Deal Size : Undisclosed
Deal Type : Merger

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Lead Product(s) : Lonigutamab
Therapeutic Area : Immunology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ACELYRIN Announces Phase 2 Data and Phase 3 Program Design for Lonigutamab
Details : VB-421 (lonigutamab) is a subcutaneously delivered humanized IgG1 monoclonal antibody targeting IGF-1R. It is being evaluated for the treatment of thyroid eye disease.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
January 06, 2025
Lead Product(s) : Lonigutamab
Therapeutic Area : Immunology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Izokibep
Therapeutic Area : Ophthalmology
Study Phase : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Acelyrin, Inc. Announces Topline Results from Phase 2b/3 Study of Izokibep for Uveitis
Details : ABY-035 (izokibep) is a small protein therapeutic designed to inhibit IL-17A with high potency. It is being evaluated for the treatment of non-infectious, non-anterior uveitis.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
December 10, 2024
Lead Product(s) : Izokibep
Therapeutic Area : Ophthalmology
Highest Development Status : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Lonigutamab
Therapeutic Area : Immunology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ACELYRIN Reports Positive Data for Lonigutamab in Thyroid Eye Disease
Details : VB-421 (lonigutamab) is a subcutaneously delivered humanized IgG1 monoclonal antibody targeting the insulin-like growth factor-1 receptor (IGF-1R). It is being evaluated for thyroid eye disease.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
March 20, 2024
Lead Product(s) : Lonigutamab
Therapeutic Area : Immunology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
CytomX Therapeutics Announces FDA Clearance of IND Applications for CX-2051 and CX-801
Details : ABY-035 (izokibep) is a small protein therapeutic designed to inhibit IL-17A with high potency through tight binding affinity. It is being evaluated for the treatment of hidradenitis suppurativa.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
March 11, 2024
Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ACELYRIN Announces Positive Results from Phase 2b/3 of Izokibep in Psoriatic Arthritis
Details : ABY-035 (izokibep) is a small protein therapeutic designed to inhibit IL-17A with high potency through tight binding affinity. It is being evaluated for the treatment of psoriatic arthritis.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
March 11, 2024
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ACELYRIN, INC. Provides Update on Izokibep Clinical Development Program
Details : Izokibep is a small protein therapeutic designed to inhibit IL-17A with high potency through tight binding affinity. It is being evaluated in phase 2/3 clinical trials for the treatment of psoriatic arthritis (PsA).
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
November 27, 2023
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Study Phase : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : IMG-020 (izokibep) is a small therapeutic protein inhibitor of interleukin-17A (IL-17A). It is designed to overcome monoclonal antibodies limitations for hidradenitis suppurativa indication. It is being investigated for moderate-to-severe Hidradenitis.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
September 11, 2023
Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Highest Development Status : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
