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Overview of D07ILP

Client Email Product
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 10-Hydroxycamptothecin; 10-Hydroxycamptothecine; NSC 107124
PharmaCompass
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3
Also known as: 19685-09-7, (s)-10-hydroxycamptothecin, Hydroxycamptothecin, 10-hydroxycamptothecine, Hydroxycamptothecine, Camptothecin, hydroxy-
Molecular Formula
C20H16N2O5
Molecular Weight
364.357  g/mol
InChI Key
HAWSQZCWOQZXHI-FQEVSTJZSA-N
FDA UNII
9Z01632KRV

10-hydroxycamptothecin is under investigation in clinical trial NCT00956787 (Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS)).
1 2D Structure

(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3

2 Identification
2.1 Computed Descriptors
2.1.1 InChI
InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
2.1.2 InChI Key
HAWSQZCWOQZXHI-FQEVSTJZSA-N
2.1.3 Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
2.1.4 Isomeric SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
2.2 Other Identifiers
2.2.1 UNII
9Z01632KRV
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 19685-09-7

2. (s)-10-hydroxycamptothecin

3. Hydroxycamptothecin

4. 10-hydroxycamptothecine

5. Hydroxycamptothecine

6. Camptothecin, Hydroxy-

7. 10-hydroxy Camptothecin

8. 10-hydroxy-camptothecin

9. (s)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

10. Camptothecin, 10-hydroxy-

11. Camptothecine, 10-hydroxy-

12. Nsc 107124

13. Unii-9z01632krv

14. Hcpt

15. (s)-10-hydroxycamptothecin Hydrate

16. (4s)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

17. Nsc107124

18. 10-hcpt

19. Chembl273862

20. (20s)-10-hydroxycamptothecin

21. Chebi:81395

22. 9z01632krv

23. 64439-81-2

24. (+)-(s)-10-hydroxycamptothecin

25. Ak-33939

26. Camptothecin, 10-hydroxy-, Camptotheca Acuminata

27. (s)-4-ethyl-4,9-dihydroxy-1,12-dihydro-14h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h)-dione

28. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4-ethyl-4,9-dihydroxy-, Hydrate, (s)-

29. Q-100241

30. (20s)-4-ethyl-4,9-dihydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

31. (s)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4h,12h)-dione

32. 10-hydroxycamptochecin

33. Camptothecin, 10-hydroxy

34. (19s)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0(2),(1)(1).0?,?.0(1)?,(2)?]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione

35. (19s)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0(2),(1)(1).0?,?.0(1)?,(2)?]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione

36. (s)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione ((s)-10-hydroxycamptothecin)

37. 10-hydroxy-cpt

38. 10hydroxy Camptothecin

39. Hydroxycamptothecin-10

40. Pubchem13092

41. Spectrum_001639

42. Specplus_000763

43. Spectrum2_001660

44. Spectrum3_001621

45. Spectrum4_001815

46. Spectrum5_000549

47. Ethyl(dihydroxy)[?]dione

48. 7-ethy Hydroxycamptothecin

49. D07ilp

50. Ac1l3y2f

51. Ac1q6aq3

52. (4s)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]chinolin-3,14(4h,12h)-dion

53. Schembl25875

54. Bspbio_003281

55. Kbiogr_002454

56. Kbioss_002119

57. Bio-0687

58. Divk1c_006859

59. Spectrum1504123

60. Spbio_001819

61. Ctk8b3047

62. Kbio1_001803

63. Kbio2_002119

64. Kbio2_004687

65. Kbio2_007255

66. Kbio3_002501

67. Ex-a988

68. Hawsqzcwoqzxhi-fqevstjzsa-n

69. Molport-002-317-316

70. (+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

71. Aob33756

72. Ebd37036

73. Hy-n0095

74. Zinc3979155

75. Camptothecine, 10-hydroxy- (8ci)

76. 2136ah

77. Anw-41680

78. Bdbm50008922

79. Ccg-38770

80. Ch-068

81. Ch0082

82. Mfcd02093100

83. S2423

84. Akos015919293

85. Ac-5502

86. Acn-035239

87. An-1351

88. Bcp9000058

89. Cs-5193

90. Db12385

91. Nsc-107124

92. Rl02475

93. Ncgc00095986-01

94. Ncgc00095986-02

95. Ncgc00095986-03

96. Ncgc00178165-01

97. Ac-13221

98. Aj-47579

99. An-38748

100. As-13196

101. Br-33939

102. H577

103. Nci60_000173

104. Sc-19239

105. Sy010687

106. Ab0013128

107. Ax8001153

108. Kb-211551

109. Ls-127397

110. Tl8001609

111. Tr-009134

112. Bg01652686

113. Ft-0607192

114. Ft-0689364

115. N2591

116. St24032108

117. 10-hydroxycamptothecin;10-hydroxy Camptothecin

118. 85h097

119. A25382

120. C17939

121. M-1114

122. (s)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4'

123. C-20977

124. Sr-05000002620

125. Sr-05000002620-1

126. Brd-k63784565-001-02-1

127. 4-ethyl-4,9-dihydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

128. (4s)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione; 10-hydroxycamptothecin; 10-hydroxycamptothecine; Nsc 107124

129. (alphas)-alpha,2-dihydroxy-alpha-ethyl-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinoline-7-acetic Acid 7,8-lactone

130. (s)-10-hydroxycamptothecin;-;(+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

131. 104155-90-0

132. 157405-42-0

133. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione-,4-ethyl-4,9-dihydroxy-, (s)-

134. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione-,4-ethyl-4,9-dihydroxy-, (s)- (9ci)

135. 1h-pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione-,4-ethyl-4,9-dihydroxy-, (s)-

136. 4-ethyl-4,10-dihydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

137. 4-ethyl-4,9-dihydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (10-hydroxycamptothecin)

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 364.357 g/mol
Molecular Formula C20H16N2O5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass364.106 g/mol
Monoisotopic Mass364.106 g/mol
Topological Polar Surface Area100 A^2
Heavy Atom Count27
Formal Charge0
Complexity774
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.


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