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    28888-44-0

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    28888-44-0
    Also known as: 28888-44-0, 6,7-dimethoxyquinazoline-2,4-dione, 2,4-dihydroxy-6,7-dimethoxyquinazoline, 6,7-dimethoxyquinazoline-2,4-diol, 6,7-dimethoxy-1h-quinazoline-2,4-dione, 6,7-dimethoxy-2,4-quinazolinedione
    Molecular Formula
    C10H10N2O4
    Molecular Weight
    222.20  g/mol
    InChI Key
    KWNQIIMVPSMYEM-UHFFFAOYSA-N
    FDA UNII
    K7867Z125J
    1 2D Structure

    28888-44-0

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6,7-dimethoxy-1H-quinazoline-2,4-dione
    2.1.2 InChI
    InChI=1S/C10H10N2O4/c1-15-7-3-5-6(4-8(7)16-2)11-10(14)12-9(5)13/h3-4H,1-2H3,(H2,11,12,13,14)
    2.1.3 InChI Key
    KWNQIIMVPSMYEM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=C(C=C2C(=C1)C(=O)NC(=O)N2)OC
    2.2 Other Identifiers
    2.2.1 UNII
    K7867Z125J
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 28888-44-0

    2. 6,7-dimethoxyquinazoline-2,4-dione

    3. 2,4-dihydroxy-6,7-dimethoxyquinazoline

    4. 6,7-dimethoxyquinazoline-2,4-diol

    5. 6,7-dimethoxy-1h-quinazoline-2,4-dione

    6. 6,7-dimethoxy-2,4-quinazolinedione

    7. 2,4(1h,3h)-quinazolinedione, 6,7-dimethoxy-

    8. 6,7-dimethoxy-2,4(1h,3h)-quinazolinedione

    9. 6,7-dimethoxy-(1h,3h)-2,4-quinazolindione

    10. 2888-44-0

    11. 6,7-dimethoxy-1,2,3,4-tetrahydroquinazoline-2,4-dione

    12. K7867z125j

    13. Ncgc00160264-01

    14. Dsstox_cid_26100

    15. Dsstox_rid_81338

    16. Dsstox_gsid_46100

    17. Cas-28888-44-0

    18. Quinazolindione

    19. Unii-k7867z125j

    20. Einecs 249-288-1

    21. 2,4-dihydroxy-6,7-dimethoxquinazoline

    22. Doxazosin Impurity D

    23. Oprea1_517280

    24. Amy244

    25. Schembl2330774

    26. Chembl1403860

    27. Dtxsid9046100

    28. Zinc120622

    29. Bcp09514

    30. Doxazosin Related Compound B

    31. Tox21_111752

    32. Bbl028249

    33. Mfcd00023889

    34. Stk400208

    35. Stl083699

    36. 6,7-dimethoxy-quinazoline-2,4-diol

    37. 6,7-dimethoxy Quinazoline-2,4-dione

    38. Akos000120307

    39. Akos005712782

    40. Tox21_111752_1

    41. 6,7-dimethoxy-2,4-quinazolinediol #

    42. Ac-8386

    43. Bs-4302

    44. Dimethoxy-2,4(1h,3h)-quinazolinedione

    45. Ncgc00263562-01

    46. Quinazoline-2,4-diol, 6,7-dimethoxy-

    47. 2,4-dihydroxy-6,7-dimethoxy Quinazoline

    48. 6,7-dimethoxy-2,4-dihydroxy Quinazoline

    49. 6,7-dimethoxy-2,4-quinazolinedione, 97%

    50. Db-019954

    51. A5439

    52. Cs-0016028

    53. D1839

    54. Ft-0620865

    55. Doxazosin Related Compound B [usp-rs]

    56. 88d440

    57. 1,2-bis(diphenylphosphino)ethanemonooxide

    58. 888d440

    59. Sr-01000945181

    60. Doxazosin Mesilate Impurity D [ep Impurity]

    61. Sr-01000945181-1

    62. W-107022

    63. 3-methyl-4-oxo-2-phenyl-4h-chromene-8-carbonitrile

    64. Q27282043

    65. Usp Doxazosin Related Compound B [usp Impurity]

    66. Ncgc00160264-01!6,7-dimethoxy-quinazoline-2,4-diol

    67. Doxazosin Impurity D, European Pharmacopoeia (ep) Reference Standard

    68. Doxazosin Related Compound B, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 222.20 g/mol
    Molecular Formula C10H10N2O4
    XLogP30.7
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count2
    Exact Mass222.06405680 g/mol
    Monoisotopic Mass222.06405680 g/mol
    Topological Polar Surface Area76.7 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity307
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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                                  4-Amino-2-Chloro-6,7- Dimethoxy Quinazoline

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                                  CAS-23680-84-4
                                  Alfuzosin HCl
                                  Almelo are the industry leaders in manufacturing advanced intermediates, Active Pharmaceutical Ingredient...
                                  Almelo are the industry leaders in manufacturing advanced intermediates, Active Pharmaceutical Ingredients (APIs) and specialty fine chemicals. With a diverse product portfolio coupled with innovative R&D, Almelo boasts of having various reputed domestic and multi-national companies as its customers.
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                                  Almelo

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                                    4-Amino-2-Chloro-6,7- Dimethoxy Quinazoline

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                                    CAS-23680-84-4
                                    Prazosin Hydrochloride
                                    Almelo are the industry leaders in manufacturing advanced intermediates, Active Pharmaceutical Ingredient...
                                    Almelo are the industry leaders in manufacturing advanced intermediates, Active Pharmaceutical Ingredients (APIs) and specialty fine chemicals. With a diverse product portfolio coupled with innovative R&D, Almelo boasts of having various reputed domestic and multi-national companies as its customers.
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                                    Almelo

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                                      2 Amino-4,5-Dimethoxy Benzonitrile

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                                      CAS-26961-27-3
                                      Alfuzosin HCl
                                      Almelo are the industry leaders in manufacturing advanced intermediates, Active Pharmaceutical Ingredient...
                                      Almelo are the industry leaders in manufacturing advanced intermediates, Active Pharmaceutical Ingredients (APIs) and specialty fine chemicals. With a diverse product portfolio coupled with innovative R&D, Almelo boasts of having various reputed domestic and multi-national companies as its customers.
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                                      Delta Finochem P Ltd

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                                      1,4-Benzodioxan-2-carboxylic acid

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                                      3663-80-7
                                      Doxazosin Mesylate
                                      Delta Finochem Pvt Ltd. is a privately owned and professionally managed company, accredited by WHO-GMP & ...
                                      Delta Finochem Pvt Ltd. is a privately owned and professionally managed company, accredited by WHO-GMP & ISO 9001:2015 (Year of establishment 1994) Delta Finochem is a leading manufacturers of Active Pharmaceutical Ingredients (Generics), Drug Intermediates, Quaternary Ammonium Compounds, Quaternary Phosphonium compounds. Our focus is on niche products, with a presence in several countries. Our partners are essentially innovators and generic drug companies across the globe for whom we develop a range of new niche products.
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                                      Indian Tex Dyes Industries

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                                        4-Amino-2-chloro-6,7-dimethoxyquinazoline

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                                        23680-84-4
                                        Doxazosin Mesylate
                                        TEXLAB INDUSTRIES was established in 1971, manufacturing & trading related business. TEXLAB INDUSTRIES - ...
                                        TEXLAB INDUSTRIES was established in 1971, manufacturing & trading related business. TEXLAB INDUSTRIES - company launched by Late Shree AMBALAL MISTRY for local and global region with the name of TEXLAB INDUSTRIES with various equipments for Textile Laboratory Testing Equipments in the field of textile testing services and also in textile laboratory processing in terms of manufacturing & trading in the day to day market. To begin with we started mfg. of textile testing equipments like Wrap Reel, Twist Tester, Lea Strength Tester, Yarn Appearance Board Winding Machine & Tensile Testers etc.
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                                        Indian Tex Dyes Industries

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                                          N-(1,4-Benzodioxan-2-carbonyl)piperazine

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                                          70918-00-2
                                          Doxazosin Mesylate
                                          TEXLAB INDUSTRIES was established in 1971, manufacturing & trading related business. TEXLAB INDUSTRIES - ...
                                          TEXLAB INDUSTRIES was established in 1971, manufacturing & trading related business. TEXLAB INDUSTRIES - company launched by Late Shree AMBALAL MISTRY for local and global region with the name of TEXLAB INDUSTRIES with various equipments for Textile Laboratory Testing Equipments in the field of textile testing services and also in textile laboratory processing in terms of manufacturing & trading in the day to day market. To begin with we started mfg. of textile testing equipments like Wrap Reel, Twist Tester, Lea Strength Tester, Yarn Appearance Board Winding Machine & Tensile Testers etc.
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                                          Luna Chemicals

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                                            Tosyl isocyanate

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                                            4083-64-1
                                            Doxazosin Mesylate
                                            LUNA Chemicals Co.,Ltd. markets and manufactures world-class quality Active Pharmaceutical Ingredients an...
                                            LUNA Chemicals Co.,Ltd. markets and manufactures world-class quality Active Pharmaceutical Ingredients and intermediate chemicals for generic pharmaceutical companies. Our Development Team focus strategically on the core therapeutic areas: cardiovascular, anti-depressant, allergic, healthcare and plant extraction. We provide technical support and efficient regulatory documentation for manufacturers, intellectual property(IP) was always carefully considered as well. We also provide excellent outsourcing services to customers and laboratory support.
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                                            Luna Chemicals

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                                              1,4-Benzodioxan-2-Carboxylic Acid

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                                              3663-80-7
                                              Doxazosin Mesylate
                                              LUNA Chemicals Co.,Ltd. markets and manufactures world-class quality Active Pharmaceutical Ingredients an...
                                              LUNA Chemicals Co.,Ltd. markets and manufactures world-class quality Active Pharmaceutical Ingredients and intermediate chemicals for generic pharmaceutical companies. Our Development Team focus strategically on the core therapeutic areas: cardiovascular, anti-depressant, allergic, healthcare and plant extraction. We provide technical support and efficient regulatory documentation for manufacturers, intellectual property(IP) was always carefully considered as well. We also provide excellent outsourcing services to customers and laboratory support.
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                                              Ningbo Inno Pharmchem Co., Ltd.

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                                                4-Amino-2-Chloro-6,7-Dimethoxyquinazoline

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                                                23680-84-4
                                                Prazosin Hydrochloride
                                                NINGBO INNO PHARMCHEM CO.,LTD. develop, pilot and commercial produce organic chemicals, pharmaceutical in...
                                                NINGBO INNO PHARMCHEM CO.,LTD. develop, pilot and commercial produce organic chemicals, pharmaceutical intermediates and nutraceuticals. We also offer custom synthesis and manufacturing service from gm to tons scale.
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                                                RR LIFESCIENCES

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                                                  3-(Methylamino)-propionitrile 98%

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                                                  693-05-0
                                                  Alfuzosin HCl
                                                  RR LIFESCIENCES manufactures products purely by organic synthesis to offer its customers a choice of prod...
                                                  RR LIFESCIENCES manufactures products purely by organic synthesis to offer its customers a choice of products in their areas. Our facilities are equipped with a range of reactor sizes, glass lined reactors and S.S. Reactors, some reactors are capable of operating at high extreme temperature. Other equipments includes Centrifuges, Vacuum Tray Drier, Multi Mills, Tray Drier, in clean finishing suites. All Our facilities are GMP complaint, designed to maintain the highest standards of safety. Our R&D scale-up capabilities from lab scale to commercialization. Our team of experts interacts with our customers from the initial stages of the project to ensure successful completion of the project. We follow stringent quality assurance norms and it has the domain expertise and state of art of facilities to develop analytical methods for evaluating quality of raw materials, intermediates and final products. Our R&D scale-up capabilities from lab scale to commercialization. Our team of experts interacts with our customers from the initial stages of the project to ensure successful completion of the project. We follow stringent quality assurance norms and it has the domain expertise and state of art of facilities to develop analytical methods for evaluating quality of raw materials, intermediates and final products.
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                                                  Shamrock Medicaments

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                                                    1,1-carbonyldiimidazole

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                                                    530-62-1
                                                    Alfuzosin HCl
                                                    Shamrock Medicaments Ltd, formerly known as Doctor Lifeline Remedies India Ltd, has an intriguing evoluti...
                                                    Shamrock Medicaments Ltd, formerly known as Doctor Lifeline Remedies India Ltd, has an intriguing evolution. Established within the robust Shamrock Group in 2001 with a hefty $35 million investment, its inception aimed to cater to the global pharmaceutical market by leveraging India's capabilities. Over time, the company diversified its offerings, expanding into custom manufacturing of pharmaceutical raw materials, intermediates, and chemicals pertinent to the pharmaceutical industry. This strategic expansion likely enabled Shamrock Medicaments Ltd to cement its position as a significant player in the pharmaceutical landscape.
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                                                    Shree Ganesh Remedies

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                                                      2-Furoyl Chloride

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                                                      527-69-5
                                                      Terazosin
                                                      Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best qualit...
                                                      Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best quality of Pharmaceutical-intermediates, Bulk drugs and Speciality Chemicals to cater the needs of pharmaceutical companies and drug companies for research and product development purpose
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                                                      Shree Ganesh Remedies

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                                                        Tetrahydro-2-furoic acid

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                                                        16874-33-2
                                                        Terazosin
                                                        Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best qualit...
                                                        Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best quality of Pharmaceutical-intermediates, Bulk drugs and Speciality Chemicals to cater the needs of pharmaceutical companies and drug companies for research and product development purpose
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                                                        Shree Ganesh Remedies

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                                                          2-Furoic Acid

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                                                          88-14-2
                                                          Prazosin Hydrochloride
                                                          Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best qualit...
                                                          Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best quality of Pharmaceutical-intermediates, Bulk drugs and Speciality Chemicals to cater the needs of pharmaceutical companies and drug companies for research and product development purpose
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                                                          Shree Ganesh Remedies

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                                                            Tetrahydro-2-furoic acid

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                                                            16874-33-2
                                                            Alfuzosin HCl
                                                            Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best qualit...
                                                            Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best quality of Pharmaceutical-intermediates, Bulk drugs and Speciality Chemicals to cater the needs of pharmaceutical companies and drug companies for research and product development purpose
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                                                            Shree Ganesh Remedies

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                                                              2-Furoic Acid

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                                                              88-14-2
                                                              Terazosin
                                                              Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best qualit...
                                                              Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best quality of Pharmaceutical-intermediates, Bulk drugs and Speciality Chemicals to cater the needs of pharmaceutical companies and drug companies for research and product development purpose
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                                                              Shree Ganesh Remedies

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                                                                2-Furoyl Chloride

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                                                                527-69-5
                                                                Prazosin Hydrochloride
                                                                Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best qualit...
                                                                Shree Ganesh Remedies is established Since 1995 with an aim to manufacture, supply and export best quality of Pharmaceutical-intermediates, Bulk drugs and Speciality Chemicals to cater the needs of pharmaceutical companies and drug companies for research and product development purpose
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                                                                Srini Pharmaceuticals

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                                                                Doxazosin Mesylate

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                                                                70918-00-2
                                                                Doxazosin Mesylate
                                                                Srini Pharmaceuticals Pvt. Ltd., was established in 1995. USFDA, TGA and KFDA approved fully integrated g...
                                                                Srini Pharmaceuticals Pvt. Ltd., was established in 1995. USFDA, TGA and KFDA approved fully integrated global pharmaceutical company, located just about 60 KM's away from the Pharma Capital of India, Hyderabad. Our manufacturing facility has five fully equipped production blocks with most efficient functional utilities with multiple clean rooms having the ability to produce 10 API's at a time, supported by central quality control laborites with all sophisticated instruments by maintaining complete QMS.
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                                                                Srini Pharmaceuticals

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                                                                Doxazosin Mesylate

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                                                                23680-84-4
                                                                Doxazosin Mesylate
                                                                Srini Pharmaceuticals Pvt. Ltd., was established in 1995. USFDA, TGA and KFDA approved fully integrated g...
                                                                Srini Pharmaceuticals Pvt. Ltd., was established in 1995. USFDA, TGA and KFDA approved fully integrated global pharmaceutical company, located just about 60 KM's away from the Pharma Capital of India, Hyderabad. Our manufacturing facility has five fully equipped production blocks with most efficient functional utilities with multiple clean rooms having the ability to produce 10 API's at a time, supported by central quality control laborites with all sophisticated instruments by maintaining complete QMS.
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                                                                euroapi-2024-05-06

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                                                                Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

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