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The grant award will fund a Phase 3 clinical trial, 3K3A-APC, which is a genetically engineered variant of the naturally occurring activated protein C (APC), is proposed to protect the brain following a stroke by reducing bleeding and inflammation.


Lead Product(s): 3K3A-Activated Protein C

Therapeutic Area: Neurology Product Name: 3K3A-APC

Highest Development Status: Phase IIProduct Type: Large molecule

Partner/Sponsor/Collaborator: National Institute of Neurological Disorders and Stroke

Deal Size: $30.0 million Upfront Cash: Undisclosed

Deal Type: Funding May 24, 2022

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ZZ Biotech’s 3K3A-APC is a genetically engineered variant of the naturally occurring activated Protein C, which plays a role in the regulation of blood clotting and inflammation. In animal models of stroke, 3K3A-APC has helped prevent bleeding caused by tPA.


Lead Product(s): 3K3A-APC

Therapeutic Area: Cardiology/Vascular Diseases Product Name: Undisclosed

Highest Development Status: Phase IIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 12, 2020

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