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The Institute of Cancer Research
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The collaboration will use NeoPhore's proprietary small molecule inhibitors of DNA mismatch repair to investigate single agent activity against tumours with defined genetic backgrounds.


Lead Product(s): Undisclosed

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: PreclinicalProduct Type: Small molecule

Recipient: NeoPhore

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration April 18, 2023

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The collaboration combines the strengths and resources of both organisations to bring forward the development of novel therapies for cancer patients worldwide.


Lead Product(s): Undisclosed

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: DiscoveryProduct Type: Large molecule

Recipient: Apollo Therapeutics

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration November 14, 2022

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The treatment combination comprised VS-6766 and defactinib, which can potentially hinder signals ovarian cancer to grow. VS-6766 is a dual RAF/MEK inhibitor of Verastem Oncology while defactinib is a FAK inhibitor.


Lead Product(s): VS-6766,Defactinib

Therapeutic Area: Oncology Product Name: VS-6766

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 19, 2021

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The OlympiA trial showed that adding olaparib for one year following standard treatment for patients who had an inherited BRCA mutation and early-stage, HER-2 negative breast cancer, cut the risk of their breast cancer returning by 42 per cent at a median 2.5-year follow-up.


Lead Product(s): Olaparib

Therapeutic Area: Oncology Product Name: Lynparza

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 04, 2021

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Study suggests that therapies which target CD38-such as the multiple myeloma drug daratumumab-could hold promise against prostate cancer too, by reawakening the anti-cancer immune response.


Lead Product(s): Daratumumab

Therapeutic Area: Oncology Product Name: Darzalex

Highest Development Status: UndisclosedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 07, 2021

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Ellipses Pharma has rapidly progressed the development of EP0042 following successful negotiations between the ICR and the company, which were led by our Business and Innovation Office.


Lead Product(s): EP0042

Therapeutic Area: Oncology Product Name: EP0042

Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Ellipses Pharma

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 19, 2021

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The BRAF drug, called PLX4720, which targets this genetic mutation, was developed at the ICR, and produces significant results in both thyroid cancers and melanomas which carry the mutation.


Lead Product(s): PLX4720,Talimogene laherparepvec,Antibodies

Therapeutic Area: Oncology Product Name: PLX4720

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: Oracle Cancer Trust

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 09, 2020

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VAC2 demonstrated remarkably potent induction of immune responses in all patients dosed to date, with high levels of peripheral antigen-specific immunogenicity observed at multiple time points and confirmed by multimer staining.


Lead Product(s): VAC2

Therapeutic Area: Oncology Product Name: AST-VAC2

Highest Development Status: Phase IProduct Type: Vaccine

Recipient: Lineage Cell Therapeutics

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 13, 2020

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