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BPN14770 (zatolmilast) is an investigational drug that is believed to work by modulating a signaling molecule called cyclic AMP (cAMP), which may promote the maturation of connections between neurons that are impaired in individuals with FXS.
Lead Product(s): Zatolmilast
Therapeutic Area: Genetic Disease Product Name: BPN14770
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 27, 2023
Details:
Preclinical animal models show that BPN14770 (zatolmilast) has potential to promote maturation of connections between neurons, which is impaired in patients with FXS, and to protect connections between neurons which otherwise are lost in patients with AD.
Lead Product(s): Zatolmilast
Therapeutic Area: Genetic Disease Product Name: BPN14770
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable July 12, 2022
Details:
In the single-center, randomized, placebo-controlled, two-way crossover study, BPN14770 demonstrated excellent safety as well as benefits on cognitive function and behavior in 30 patients with FXS.
Lead Product(s): Zatolmilast
Therapeutic Area: Genetic Disease Product Name: BPN14770
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable November 02, 2020
Details:
As a result of this acquisition, Shionogi will have all global rights to BPN14770 and all Tetra compounds.
Lead Product(s): Zatolmilast
Therapeutic Area: Neurology Product Name: Undisclosed
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Shionogi
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Acquisition May 26, 2020
Details:
This expanded alliance with Shionogi further validates Tetra's platform and the potential for BPN14770 to provide a new treatment option for patients suffering from Alzheimer’s disease.
Lead Product(s): Zatolmilast
Therapeutic Area: Neurology Product Name: Undisclosed
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Shionogi
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Collaboration March 06, 2020
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