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SY-1425 (tamibarotene) is a first-in-class selective retinoic acid receptor alpha (RARα) agonist. It is being evaluated in combination with azacitidine for the treatment of newly diagnosed higher-risk myelodysplastic syndrome (HR-MDS) patients with RARA gene overexpression.
Lead Product(s): Tamibarotene,Azacitidine
Therapeutic Area: Oncology Product Name: SY-1425
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 25, 2024
Details:
The net proceeds will be used to fund the ongoing clinical development of SY-1425 (tamibarotene), a first-in-class selective retinoic acid receptor alpha (RARα) agonist, being developed for myelodysplastic syndromes.
Lead Product(s): Tamibarotene,Azacitidine
Therapeutic Area: Oncology Product Name: SY-1425
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: TD Cowen
Deal Size: $45.0 million Upfront Cash: Undisclosed
Deal Type: Public Offering December 19, 2023
Details:
SELECT-AML-1 is evaluating the safety and efficacy of SY-1425 (tamibarotene) in combination with venetoclax and azacitidine compared to venetoclax and azacitidine in patients patients with acute myeloid leukemia and RARA gene overexpression.
Lead Product(s): Tamibarotene,Azacitidine,Venetoclax
Therapeutic Area: Oncology Product Name: SY-1425
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable December 06, 2023
Details:
Syros used its proprietary gene control platform to identify novel therapeutic targets with a focus in myeloproliferative neoplasms, and Incyte received options to obtain worldwide rights to intellectual property resulting from the collaboration for up to 7 validated targets.
Lead Product(s): Undisclosed
Therapeutic Area: Oncology Product Name: Undisclosed
Highest Development Status: DiscoveryProduct Type: Undisclosed
Partner/Sponsor/Collaborator: Incyte Corporation
Deal Size: $189.0 million Upfront Cash: $10.0 million
Deal Type: Termination August 14, 2023
Details:
SY-1425 (tamibarotene), an oral first-inclass selective retinoic acid receptor alpha (RARα) agonist, is currently being evaluated in combination with azacitidine for the treatment of newly diagnosed HR-MDS patients with RARA gene overexpression.
Lead Product(s): Tamibarotene,Azacitidine
Therapeutic Area: Oncology Product Name: SY-1425
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable January 26, 2023
Details:
The rates of myelosuppression were comparable to SY-1425 (azacitidine) monotherapy in this population suggesting no added hematologic toxicity from tamibarotene when used in combination with azacitidine. The majority of non-hematologic adverse events (AEs) were low grade.
Lead Product(s): Tamibarotene,Azacitidine
Therapeutic Area: Oncology Product Name: SY-1425
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable December 12, 2022
Details:
SY-1425, having tamibarotene in combination with venetoclax and azacitidine administered at approved doses showed no evidence of increased toxicity relative to the doublet combination of venetoclax and azacitidine.
Lead Product(s): Tamibarotene,Azacitidine,Venetoclax
Therapeutic Area: Oncology Product Name: SY-1425
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable December 10, 2022
Details:
The SELECT-AML-1 trial is evaluating SY-1425 (tamibarotene), first-in-class selective retinoic acid receptor alpha (RARα) agonist, in combination with venetoclax and azacitidine in patients with newly diagnosed, unfit acute myeloid leukemia (AML) with RARA gene overexpression.
Lead Product(s): Tamibarotene,Azacitidine,Venetoclax
Therapeutic Area: Oncology Product Name: SY-1425
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable November 03, 2022
Details:
SM-88 (racemetyrosine) is an orally administered cancer metabolism-based therapy that is chemically altered to be non-functional for fundamental tumor cell processes, including protein synthesis.
Lead Product(s): Methyltyrosine,Methoxsalen,Phenytoin
Therapeutic Area: Oncology Product Name: SM-88
Highest Development Status: Phase II/ Phase IIIProduct Type: Small molecule
Recipient: Tyme Technologies
Deal Size: $130.0 million Upfront Cash: Undisclosed
Deal Type: Private Placement September 16, 2022
Details:
Tamibarotene (formerly SY-1425) is an oral first-in-class selective retinoic acid receptor alpha (RARα) agonist that we are developing for genomically defined subsets of patients whose disease is characterized by the overexpression of the RARA gene.
Lead Product(s): Tamibarotene,Azacitidine
Therapeutic Area: Oncology Product Name: SY-1425
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Oxford Finance
Deal Size: $130.0 million Upfront Cash: Undisclosed
Deal Type: Private Placement September 16, 2022
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