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Synaffix
Netherlands1 Flag
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Netherlands
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Kloosterstraat 9 5349 AB Oss, Netherlands
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+31 88 022 4505
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Under the terms of the expanded agreement, Innovent will be responsible for the research, development, manufacturing and commercialization of new ADC candidates, including IBI343, a recombinant human anti-Claudin 18.2 monoclonal antibody-drug conjugate.


Lead Product(s): IBI-343

Therapeutic Area: Oncology Product Name: IBI-343

Highest Development Status: Phase IProduct Type: Large molecule

Partner/Sponsor/Collaborator: Innovent Biologics

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement December 06, 2023

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Under the agreement, SOTIO will leverage Synaffix’s antibody-drug conjugate platform for the design of up to three novel ADCs targeting distinct tumor-associated antigens.


Lead Product(s): Undisclosed

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: Discovery PlatformProduct Type: Large molecule

Partner/Sponsor/Collaborator: Sotio

Deal Size: $740.0 million Upfront Cash: Undisclosed

Deal Type: Licensing Agreement October 16, 2023

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Under the agreement, ABL Bio will be responsible for the research, development, and commercialization of bispecific ADCs, designed to overcome the limitations of conventional therapeutic ADCs that target only a single antigen on the targeted cancer cell.


Lead Product(s): Undisclosed

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: DiscoveryProduct Type: Large molecule

Partner/Sponsor/Collaborator: ABL Bio

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement September 13, 2023

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Under the agreement, MacroGenics gained access to Synaffix's clinical stage GlycoConnect™ antibody conjugation technology, HydraSpace™ polar spacer technology, as well as select toxSYN™ linker-payloads, each designed to enable ADCs with best-in-class efficacy and tolerability.


Lead Product(s): Antibody-drug Conjugate

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: DiscoveryProduct Type: Large molecule

Partner/Sponsor/Collaborator: MacroGenics

Deal Size: $2,200.0 million Upfront Cash: Undisclosed

Deal Type: Licensing Agreement March 14, 2023

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Under the terms of the licensing agreement, Synaffix will provide access to proprietary Antibody-Drug Conjugate technologies to CKD Pharm, comprising GlycoConnect™, HydraSpace™ and an undisclosed linker-payload from the toxSYN™ platform.


Lead Product(s): Antibody-drug Conjugate

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: DiscoveryProduct Type: Large molecule

Partner/Sponsor/Collaborator: Chong Kun Dang Pharm

Deal Size: $132.0 million Upfront Cash: Undisclosed

Deal Type: Licensing Agreement February 06, 2023

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Amgen will gain access to Synaffix's antibody conjugation technology platforms comprising GlycoConnect™, HydraSpace™ and select toxSYN™ linker-payloads for one Antibody Drug Conjugate (ADC) program.


Lead Product(s): Antibody-drug Conjugate-based Therapy

Therapeutic Area: Technology Product Name: Undisclosed

Highest Development Status: Discovery PlatformProduct Type: Large molecule

Partner/Sponsor/Collaborator: Amgen Inc

Deal Size: $2,000.0 million Upfront Cash: Undisclosed

Deal Type: Licensing Agreement January 05, 2023

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Under the terms of the agreement, Hummingbird Bio is granted rights to utilize Synaffix proprietary Antibody-Drug Conjugate (ADC) technologies GlycoConnect™ and HydraSpace™, in combination with select toxSYN™ linker-payloads.


Lead Product(s): Antibody-drug Conjugate-based Therapy

Therapeutic Area: Technology Product Name: Undisclosed

Highest Development Status: PreclinicalProduct Type: Large molecule

Partner/Sponsor/Collaborator: Hummingbird Bioscience

Deal Size: $150.0 million Upfront Cash: Undisclosed

Deal Type: Licensing Agreement January 04, 2023

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Emergence will be responsible for the research, development, manufacturing and commercialization of the ADCs. Synaffix will be responsible for the manufacturing of components that are specifically related to its proprietary technologies.


Lead Product(s): Antibody-drug Conjugate

Therapeutic Area: Technology Product Name: Undisclosed

Highest Development Status: PreclinicalProduct Type: Large molecule

Partner/Sponsor/Collaborator: Emergence Therapeutics

Deal Size: Undisclosed Upfront Cash: $360.0 million

Deal Type: Licensing Agreement September 06, 2022

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The technology licensed from Synaffix include GlycoConnect™, HydraSpace™, and multiple toxSYN™ linker-payloads, which allow for the drug-to-antibody ratio (DAR) to be tailored to 1, 2 or 4 to optimize the therapeutic index of the ADC.


Lead Product(s): Antibody-drug Conjugate Therapeutic

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: PreclinicalProduct Type: Large molecule

Partner/Sponsor/Collaborator: Kyowa Kirin

Deal Size: $176.0 million Upfront Cash: $5.0 million

Deal Type: Licensing Agreement June 30, 2022

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Under the licensing agreement, MacroGenics will gain access to Synaffix’s clinical stage GlycoConnect™ antibody conjugation technology, HydraSpace™ polar spacer technology, as well as select toxSYN™ linker-payloads for the discovery of Antibody-drug Conjugate.


Lead Product(s): Antibody-drug Conjugate

Therapeutic Area: Technology Product Name: Undisclosed

Highest Development Status: Discovery PlatformProduct Type: Large molecule

Partner/Sponsor/Collaborator: MacroGenics

Deal Size: $586.0 million Upfront Cash: Undisclosed

Deal Type: Agreement February 03, 2022

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