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    Replay's Cell Therapy Product Company Syena Announces First Patient Dosed in Phase 1/2 study of TCR-NK Cell Therapy for Multiple Myeloma

    Details:

    NY-ESO-1 TCR/IL-15 NK, an engineered T-cell receptor natural killer (TCR-NK) cell therapy, which is being evaluated for the treatment of patients with relapsed or refractory multiple myeloma.


    Lead Product(s): NY-ESO-1 TCR/IL-15,Fludarabine Phosphate,Cyclophosphamide

    Therapeutic Area: Oncology Product Name: NY-ESO-1 TCR/IL-15

    Highest Development Status: Phase I/ Phase IIProduct Type: Cell and Gene therapy

    Partner/Sponsor/Collaborator: Syena

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable March 11, 2024

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    Replay Announces Partnership Between Product Company Syena and JURA Bio to Advance T Cell Receptor NK Therapies in Cancer

    Details:

    The collaboration aims to develop T cell receptor (TCR) based NK therapies in cancer by leveraging JURA Bio’s T cell receptor discovery platform to discover and develop innovative therapies by applying AI/machine learning.


    Lead Product(s): T-cell Receptor Based Therapy

    Therapeutic Area: Oncology Product Name: Undisclosed

    Highest Development Status: Discovery PlatformProduct Type: Cell and Gene therapy

    Recipient: Jura Bio

    Deal Size: Undisclosed Upfront Cash: Undisclosed

    Deal Type: Collaboration September 21, 2023

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    Replay and MD Anderson Announce FDA Clearance of IND Application for First-in-Class T-Cell Receptor Natural Killer (TCR-NK) Cell Therapy for Multiple My...

    Details:

    NY-ESO-1 TCR/IL-15 NKs are adoptive Natural Killer (NK) cells expressing an affinity-enhanced T-cell receptor (TCR) reactive directed against the NY-ESO-1-specific cord blood-derived NK cells.


    Lead Product(s): NY-ESO-1 TCR/IL-15 NK Cell Therapy

    Therapeutic Area: Oncology Product Name: Undisclosed

    Highest Development Status: IND EnablingProduct Type: Cell and Gene therapy

    Partner/Sponsor/Collaborator: The University of Texas MD Anderson Cancer Center

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable July 24, 2023

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    Replay and MD Anderson Announce FDA Clearance of IND Application for First-in-class T-Cell Receptor Natural Killer (TCR-NK) Cell Therapy for Sarcoma

    Details:

    NY-ESO-1 TCR/IL-15 NK is an engineered T-Cell Receptor Natural Killer (TCR-NK) cell therapy for advanced synovial sarcoma and myxoid/round cell liposarcoma.


    Lead Product(s): NY-ESO-1 TCR/IL-15 NK Cell Therapy

    Therapeutic Area: Oncology Product Name: Undisclosed

    Highest Development Status: IND EnablingProduct Type: Cell and Gene therapy

    Partner/Sponsor/Collaborator: The University of Texas MD Anderson Cancer Center

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable June 20, 2023

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    KKR-backed Replay and MD Anderson Form New Product Company Syena to Pioneer First-In-Class TCR-NK Cell Therapy

    Details:

    TCR-NK cell platform targets a selection of validated cancer neoantigens, including NY-ESO-1, and additional undisclosed TCRs. The NY-ESO-1 program in hematological malignancies and solid tumors.


    Lead Product(s): TCR-NK Cell Therapy

    Therapeutic Area: Oncology Product Name: Undisclosed

    Highest Development Status: PreclinicalProduct Type: Cell and Gene therapy

    Partner/Sponsor/Collaborator: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable February 14, 2023

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    Replay Receives $1.5 Million Grant For Its Hypoimmunogenic Technology Platform

    Details:

    Replay’s uCell™ platform is an off-the-shelf, genomically rewritten, hypoimmunogenic technology that allows allogeneic donor-derived primary cells and iPSCs (Induced Pluripotent Stem Cells) to be made immune silent.


    Lead Product(s): iPSC-derived Immune Cell Therapy

    Therapeutic Area: Oncology Product Name: uCell

    Highest Development Status: UndisclosedProduct Type: Cell and Gene therapy

    Partner/Sponsor/Collaborator: Bill & Melinda Gates Foundation

    Deal Size: $1.5 million Upfront Cash: Undisclosed

    Deal Type: Funding November 28, 2022

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    Replay Launches Big DNA HSV Gene Therapy Company, Telaria, Focused on Rare Skin Diseases

    Details:

    Telaria is the second of Replay’s four synHSV™ gene therapy product companies and its launch follows that of Eudora, a company targeting genetic diseases of the retina.


    Lead Product(s): SynHSV Gene Therapy

    Therapeutic Area: Genetic Disease Product Name: Undisclosed

    Highest Development Status: DiscoveryProduct Type: Cell and Gene therapy

    Partner/Sponsor/Collaborator: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable November 21, 2022

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    Replay Launches with $55 Million Seed to Reprogram Biology by Writing and Delivering Big DNA

    Details:

    Replay’s synHSV™ technology, a high payload capacity HSV vector capable of delivering up to 30 times the payload of AAV, is utilized by Replay’s four gene therapy product companies, bringing big DNA treatments to diseases affecting the skin, eye, brain, and muscle.


    Lead Product(s): AAV-based Gene Therapy

    Therapeutic Area: Genetic Disease Product Name: Undisclosed

    Highest Development Status: UndisclosedProduct Type: Cell and Gene therapy

    Partner/Sponsor/Collaborator: KKR

    Deal Size: $55.0 million Upfront Cash: Undisclosed

    Deal Type: Financing July 25, 2022

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