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950 Winter Street Waltham, MA 02451
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617-551-4000

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Under the agreement, EffRx will grant Radius an exclusive, royalty bearing license to Binosto (alendronate sodium), an effervescent tablet for oral solution indicated for osteoporosis in postmenopausal women and to increase bone mass in men with osteoporosis, in the US.


Lead Product(s): Alendronate Sodium

Therapeutic Area: Musculoskeletal Product Name: Binosto

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: EffRx Pharmaceuticals

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement September 19, 2023

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Under the agreement, DRI Healthcare gains a portion of Radius’s royalty and commercial milestone stream in Orserdu (elacestrant), a selective estrogen receptor degrader and the first and only treatment approved for ER+/HER2-, ESR1- mutated advanced or metastatic breast cancer.


Lead Product(s): Elacestrant

Therapeutic Area: Oncology Product Name: Orserdu

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: DRI Healthcare

Deal Size: $140.0 million Upfront Cash: $130.0 million

Deal Type: Agreement August 14, 2023

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Theramex will commercialise and distribute Eladynos (abaloparatide), a novel bone forming agent indicated for the treatment of osteoporosis in postmenopausal women at increased risk of fractures on an exclusive basis in the European Economic Area, UK , Australia and Brazil.


Lead Product(s): Abaloparatide Acetate

Therapeutic Area: Musculoskeletal Product Name: Eladynos

Highest Development Status: ApprovedProduct Type: Peptide

Partner/Sponsor/Collaborator: Theramex

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement March 20, 2023

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Elacestrant (RAD1901), if approved, would be the first oral selective estrogen receptor degrader (SERD) to be available for patients suffering from second-line (2L) and third-line (3L) ER+/HER2- advanced or metastatic breast cancer in the European Union.


Lead Product(s): Elacestrant

Therapeutic Area: Oncology Product Name: RAD1901

Highest Development Status: Phase IIIProduct Type: Small molecule

Recipient: Menarini

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 19, 2022

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Radius’ lead product, TYMLOS® (abaloparatide) was launched in the U.S. in 2017 for the treatment of postmenopausal women with osteoporosis at high risk for fracture.


Lead Product(s): Abaloparatide Acetate

Therapeutic Area: Musculoskeletal Product Name: Tymlos

Highest Development Status: ApprovedProduct Type: Peptide

Partner/Sponsor/Collaborator: Gurnet Point Capital

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Acquisition August 15, 2022

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The acquisition of Radius by Gurnet Point and Patient Square provides our shareholders with attractive, immediate value at a compelling premium, in addition to the potential future upside of TYMLOS (abaloparatide) through the CVR.


Lead Product(s): Abaloparatide Acetate

Therapeutic Area: Musculoskeletal Product Name: Tymlos

Highest Development Status: ApprovedProduct Type: Peptide

Partner/Sponsor/Collaborator: Gurnet Point Capital

Deal Size: $890.0 million Upfront Cash: $547.0 million

Deal Type: Acquisition August 15, 2022

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Investigational drug RAD011 is a pharmaceutical-grade synthetic cannabidiol oral solution, manufactured utilizing traditional pharmaceutical manufacturing processes.


Lead Product(s): Cannabidiol

Therapeutic Area: Genetic Disease Product Name: RAD011

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable July 07, 2022

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The acquisition of Radius by Gurnet Point and Patient Square provides our shareholders with attractive, immediate value at a compelling premium, in addition to the potential future upside of TYMLOS (abaloparatide) through the CVR.


Lead Product(s): Abaloparatide Acetate

Therapeutic Area: Musculoskeletal Product Name: Tymlos

Highest Development Status: ApprovedProduct Type: Peptide

Partner/Sponsor/Collaborator: Gurnet Point Capital

Deal Size: $890.0 million Upfront Cash: $547.0 million

Deal Type: Acquisition June 23, 2022

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RAD1901 (elacestrant) is the first and currently only investigational oral SERD to show positive topline results in a pivotal trial for the treatment of ER+/HER2- advanced or metastatic breast cancer in postmenopausal women, and men.


Lead Product(s): Elacestrant

Therapeutic Area: Oncology Product Name: RAD1901

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Menarini

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 22, 2022

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Elacestrant (RAD1901), is an investigational selective estrogen receptor degrader (SERD), out-licensed to Menarini Group, which is being evaluated for potential use as a once daily oral treatment in patients with ER+/ HER2- advanced breast cancer.


Lead Product(s): Elacestrant

Therapeutic Area: Oncology Product Name: RAD1901

Highest Development Status: Phase IIIProduct Type: Small molecule

Recipient: Menarini

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 06, 2022

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