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1035 Cambridge Street Suite #17B Cambridge, MA 02141
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Novellus’ BRAF program focuses on patient populations for which there are currently no FDA-approved BRAF inhibitors, including BRAF fusions and BRAF-mutated gliomas.


Lead Product(s): Plixorafenib

Therapeutic Area: Oncology Product Name: PLX-8394

Highest Development Status: Phase I/ Phase IIProduct Type: Small molecule

Recipient: Tempus

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration November 23, 2020

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NoveCite will develop and commercialize Novellus's iMSCs to treat acute respiratory conditions with a near term focus on Acute Respiratory Distress Syndrome ("ARDS") associated with COVID-19.


Lead Product(s): Induced Mesenchymal Stem Cells

Therapeutic Area: Infections and Infectious Diseases Product Name: Undisclosed

Highest Development Status: UndisclosedProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: NoveCite

Deal Size: $56.0 million Upfront Cash: $5.0 million

Deal Type: Licensing Agreement October 13, 2020

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Novellus, a Cambridge, Mass-based cell engineering company, has developed patented, non-immunogenic mRNA-based induced mesenchymal stem cell (iMSC) platform.


Lead Product(s): NC-iMSCs therapy

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: Undisclosed

Highest Development Status: UndisclosedProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Citius Pharmaceuticals

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement October 07, 2020

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Proceeds will fund the clinical development of PLX-8394 for patients with BRAF fusions and glioma patients with BRAF mutations.


Lead Product(s): Plixorafenib

Therapeutic Area: Oncology Product Name: PLX-8394

Highest Development Status: Phase I/ Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Pontifax

Deal Size: $57.0 million Upfront Cash: Undisclosed

Deal Type: Series C Financing September 21, 2020

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Under the terms of the agreement, Plexxikon grants Novellus rights to research, develop, manufacture and exclusively commercialize PLX8394 worldwide.


Lead Product(s): Plixorafenib

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: Phase I/ Phase IIProduct Type: Small molecule

Recipient: Plexxikon

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement May 03, 2020

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Citius signed an exclusive six-month option agreement to in-license a stem-cell therapy for acute respiratory distress syndrome from a subsidiary of Novellus.


Lead Product(s): Mesenchymal stem cells

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: Undisclosed

Highest Development Status: UndisclosedProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Citius Pharmaceuticals

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement April 01, 2020

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