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NLY01 is a proprietary long-acting analogue of exendin-4, a glucagon-like peptide-1 receptor (GLP-1R) agonist that slows progression in animal models of parkinson’s and alzheimer’s disease.
Lead Product(s): Exenatide
Therapeutic Area: Neurology Product Name: NLY01
Highest Development Status: Phase IIProduct Type: Peptide
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 27, 2023
Details:
NLY01, Neuraly’s lead development asset, is a glucagon-like peptide 1 receptor agonist that has been demonstrated to inhibit pathological activation of microglia by binding upregulated GLP-1R in animal models of neurodegenerative diseases such as PD.
Lead Product(s): NLY01
Therapeutic Area: Neurology Product Name: NLY01
Highest Development Status: Phase IIProduct Type: Peptide
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable April 19, 2022
Details:
Preclinical study in glaucoma, in combination with Neuraly’s clinical trials assessing NLY01 in Parkinson’s and Alzheimer’s reflects the growing evidence that NLY01 can deliver a neuroprotective effect across a number of challenging diseases.
Lead Product(s): NLY01
Therapeutic Area: Ophthalmology Product Name: NLY01
Highest Development Status: PreclinicalProduct Type: Peptide
Recipient: University of Pennsylvania
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Agreement November 10, 2020
Details:
Novel mechanism of action inhibits pathological activation of microglial cells and prevents neuronal cell death.
Lead Product(s): NLY01
Therapeutic Area: Neurology Product Name: Undisclosed
Highest Development Status: Phase IIProduct Type: Peptide
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 03, 2020
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