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The acquisition will provide Gilead with Hepcludex™ (bulevirtide), which was conditionally approved by the European Medicines Agency (EMA) for the treatment of chronic HDV infection in adults with compensated liver disease in July 2020.


Lead Product(s): Bulevirtide Acetate

Therapeutic Area: Infections and Infectious Diseases Product Name: Hepcludex

Highest Development Status: ApprovedProduct Type: Peptide

Partner/Sponsor/Collaborator: Gilead Sciences

Deal Size: $1,762.0 million Upfront Cash: $1,400.0 million

Deal Type: Acquisition December 10, 2020

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On July 31st HEPCLUDEX® was granted Conditional Marketing Authorization (CMA) by the European Commission as the first approved treatment in Europe for adult patients with chronic hepatitis delta virus (HDV) infection and compensated liver disease.


Lead Product(s): Bulevirtide Acetate

Therapeutic Area: Infections and Infectious Diseases Product Name: Hepcludex

Highest Development Status: ApprovedProduct Type: Peptide

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 17, 2020

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HEPCLUDEX® has been approved as the first treatment option for adult patients with chronic hepatitis delta virus infection and compensated liver disease in Europe.


Lead Product(s): Bulevirtide

Therapeutic Area: Infections and Infectious Diseases Product Name: Hepcludex

Highest Development Status: ApprovedProduct Type: Peptide

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 04, 2020

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The benefit of HEPCLUDEX® is shown by an effective reduction of HDV RNA levels and improvement of liver inflammation.


Lead Product(s): Bulevirtide

Therapeutic Area: Infections and Infectious Diseases Product Name: Undisclosed

Highest Development Status: Phase IIIProduct Type: Peptide

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 29, 2020

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