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Under the terms of the agreement, the companies will jointly conduct research and preclinical development activities to identify novel monovalent small molecules that modulate target proteins through activation, stabilization or degradation as potential development candidates.


Lead Product(s): Undisclosed

Therapeutic Area: Technology Product Name: Undisclosed

Highest Development Status: Discovery PlatformProduct Type: Small molecule

Recipient: Generian Pharmaceuticals

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration February 08, 2023

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ACMSD is a key enzyme involved in the de novo synthesis of NAD+, which is critical to mitochondrial function via maintenance of cellular redox state. TLC-065, is being advanced for the treatment of a range of metabolic and inflammatory liver and kidney disorders.


Lead Product(s): TLC-065

Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: TLC-065

Highest Development Status: PreclinicalProduct Type: Undisclosed

Partner/Sponsor/Collaborator: OrsoBio

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Acquisition November 02, 2022

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