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EPIEFFECT is a lyophilized human placental-based allograft consisting of amnion and chorion membranes, while also retaining the intermediate layer. EPIEFFECT is intended for use as a barrier, to provide a protective environment in acute and chronic wounds.


Lead Product(s): Lyophilized Human Placental-based Allograft

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: Epieffect

Highest Development Status: ApprovedProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 26, 2023

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Under the collaboration, MIMEDX will provide its market leading placental tissue allograft EPIFIX® to be used during the wound healing phase of the EscharEx® (concentrate of proteolytic enzymes enriched in bromelain) Phase III study in venous leg ulcers (VLUs).


Lead Product(s): Bromelain Enriched Proteolytic Enzyme,Dehydrated Human Amnion Membrane

Therapeutic Area: Podiatry Product Name: EscharEx

Highest Development Status: PreclinicalProduct Type: Large molecule

Partner/Sponsor/Collaborator: MediWound

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration August 15, 2023

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EPIFIX (human amnion membrane allograft) is a PURION® processed placental tissue allograft that supports the healing cascade by providing a semi-permeable, protective barrier over wounds.


Lead Product(s): Human Amnion Membrane Allograft

Therapeutic Area: Podiatry Product Name: Epifix

Highest Development Status: ApprovedProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Gunze Medical Limited

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement January 04, 2023

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AXIOFILL is an acellular human extracellular matrix (ECM) derived from the placental disc. AXIOFILL preserves multiple ECM components and other matrix-bound proteins and is intended for use in the replacement or supplementation of damaged or inadequate integumental tissue.


Lead Product(s): Acellular Human Extracellular Matrix

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: Axiofill

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 20, 2022

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EPIFIX (Human Amnion-chorion Membrane Allograft) is a PURION® processed placental tissue allograft that supports the healing cascade by providing a protective barrier over wounds.


Lead Product(s): Human Amnion Membrane Allograft

Therapeutic Area: Podiatry Product Name: Epifix

Highest Development Status: ApprovedProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 12, 2022

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The award will be used to advance the clinical understanding of PURION® processed Dehydrated Human Amnion Chorion Membrane, specifically in treating acute injuries and preventing initially partial-thickness burns from deteriorating to full-thickness burns.


Lead Product(s): Dehydrated Human Amnion Chorion Membrane

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: DHACM

Highest Development Status: UndisclosedProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: U.S. Army Medical Research and Development

Deal Size: $4.6 million Upfront Cash: Undisclosed

Deal Type: Funding May 31, 2022

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Data show mdHACM mitigates effects of inflammatory-induced degeneration in chondrocytes, the Primary Cell Type in Cartilage. These results further support mdHACM as an investigational new drug candidate for the treatment of OA and highlight potential disease activities.


Lead Product(s): Micronized Dehydrated Human Amnion Chorion Membrane

Therapeutic Area: Musculoskeletal Product Name: Undisclosed

Highest Development Status: IND EnablingProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 01, 2021

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MIMEDX Purion processed dHACM has been used extensively for the treatment of multiple acute and chronic conditions ranging from diabetic foot ulcers and significant burn injuries to musculoskeletal and sports medicine applications.


Lead Product(s): Purion Processed Dehydrated Human Amnion/Chorion Membrane

Therapeutic Area: Dermatology Product Name: Undisclosed

Highest Development Status: PreclinicalProduct Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 15, 2021

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