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    Lighthouse Pharmaceuticals Announces FDA Approval To Proceed With Phase 2 Spring Trial Of LHP588, A Next-Generation Treatment For P. Gingivalis-positive...

    Details:

    LHP588 is the company's next-generation, brain penetrant small-molecule gingipain inhibitor, being developed for the treatment of P. gingivalis-positive Alzheimer's disease.


    Lead Product(s): LHP588

    Therapeutic Area: Neurology Product Name: LHP588

    Highest Development Status: Phase IProduct Type: Small molecule

    Partner/Sponsor/Collaborator: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable November 16, 2023

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    Lighthouse Pharmaceuticals Announces Progression of LHP588 Clinical Development Program in Alzheimer's Disease

    Details:

    LHP588 is a Phase 2b, orally available small molecule, targets a specific, infectious pathogen, Porphyromonas gingivalis, associated with chronic degenerative and inflammatory disorders including dementia, periodontal disease, atherosclerosis, and orodigestive cancers.


    Lead Product(s): LHP588

    Therapeutic Area: Neurology Product Name: LHP588

    Highest Development Status: IND EnablingProduct Type: Small molecule

    Partner/Sponsor/Collaborator: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable May 10, 2023

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    Quince Therapeutics Completes the Sale of Legacy Protease Inhibitor Portfolio to Lighthouse Pharmaceuticals

    Details:

    Under the agreement, Lighthouse gains exclusive rights to develop, manufacture, and commercialize Quince’s legacy protease inhibitor portfolio including, COR588, COR388, COR852, and COR803 globally.


    Lead Product(s): COR588

    Therapeutic Area: Neurology Product Name: COR588

    Highest Development Status: Phase IProduct Type: Small molecule

    Partner/Sponsor/Collaborator: Quince Therapeutics

    Deal Size: $150.0 million Upfront Cash: Undisclosed

    Deal Type: Divestment January 30, 2023

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