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Details:

Proceeds drawn by LIDDS under the convertible notes agreement will be used to further advance the project in clinical development, creating a solid foundation for new partnerships and license agreements for Liproca, based on the NanoZolid® technology.


Lead Product(s): 2-Hydroxyflutamide

Therapeutic Area: Oncology Product Name: Liproca

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Nice & Green

Deal Size: $4.3 million Upfront Cash: Undisclosed

Deal Type: Financing February 22, 2022

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NZ-DTX-001 is intratumoural depot formulation of NanoZolid® in combination with docetaxel for treatment of solid tumors.


Lead Product(s): NanoZolid-Docetaxel

Therapeutic Area: Oncology Product Name: NZ-DTX

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 04, 2021

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The study will assess intratumoral injections of NZ-DTX Depot, containing the cytotoxic agent docetaxel, in men with prostate cancer who are scheduled for prostatectomy.


Lead Product(s): Docetaxel

Therapeutic Area: Oncology Product Name: NZ-DTX

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 16, 2021

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Details:

The collaboration enables LIDDS to expand the manufacturing of new product candidates, e.g. including biomolecules and cytostatics, in addition to the already existing collaboration with Recipharm for Liproca Depot.


Lead Product(s): NZ-TLR9

Therapeutic Area: Oncology Product Name: NZ-TLR9

Highest Development Status: PreclinicalProduct Type: Undisclosed

Recipient: Pharmidea

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration February 26, 2021

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Details:

The study met both primary and secondary endpoints by confirming efficacy and safety with Liproca Depot given as intraprostatic injection in low- and intermediate risk prostate cancer patients.


Lead Product(s): 2-Hydroxyflutamide

Therapeutic Area: Oncology Product Name: Liproca Depot

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 04, 2021

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The results indicate that NanoZolid technology®, with controlled & sustained drug release, can be used to treat deep lying cancer tumors, which are not suitable to be treated with standard TLR9 due to the necessity of weekly injections.


Lead Product(s): NZ-TLR9

Therapeutic Area: Oncology Product Name: NZ-TLR9

Highest Development Status: PreclinicalProduct Type: Undisclosed

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 26, 2020

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Details:

In patients who received a second Liproca® Depot injection (6 of 12), at 2 months post treatment, PSA levels were in average reduced by 28 %.


Lead Product(s): 2-Hydroxyflutamide

Therapeutic Area: Oncology Product Name: Liproca Depot

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 30, 2020

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Details:

Final data from the LPC-004 study confirms Liproca® Depot’s potential as a safe and effective anti-androgen treatment for prostate cancer patients that currently are not treated but kept under ‘Active Surveillance’.


Lead Product(s): 2-Hydroxyflutamide

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 19, 2020

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Details:

Dose escalation in the Phase I study NZ-DTX is proceeding according to the protocol, with additional patients being treated at a higher dose level of NZ-DTX.


Lead Product(s): Docetaxel

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 01, 2020

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Details:

Clinical data have shown that intratumoral delivery of TLR9 agonists can effectively treat solid cancers.


Lead Product(s): NZ-TLR9

Therapeutic Area: Oncology Product Name: Undisclosed

Highest Development Status: PreclinicalProduct Type: Undisclosed

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 25, 2020

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