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Fruzaqla (fruquintinib) is a selective oral VEGFR inhibitor it plays a pivotal role in blocking tumor angiogenesis. It is being investigated in combination with sintilimab (PD-1 inhibitor) for the treatment of advanced endometrial cancer.
Lead Product(s): Fruquintinib,Sintilimab
Therapeutic Area: Oncology Product Name: Fruzaqla
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Innovent Biologics
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable April 01, 2024
Details:
Orpathys (savolitinib) is an oral, potent and highly selective MET tyrosine kinase inhibitor. It is indicated for the treatment of patients with non-small cell lung cancer with MET exon 14 skipping alterations.
Lead Product(s): Savolitinib
Therapeutic Area: Oncology Product Name: Orpathys
Highest Development Status: ApprovedProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 27, 2024
Details:
HMPL-523 (sovleplenib) is a novel, investigational, selective small molecule inhibitor for oral administration targeting the spleen tyrosine kinase, also known as Syk. It is being evaluated for the treatment of warm antibody autoimmune hemolytic anemia.
Lead Product(s): Sovleplenib
Therapeutic Area: Immunology Product Name: HMPL-523
Highest Development Status: Phase II/ Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 21, 2024
Details:
Inmagene has exercised options to license two drug candidates discovered by HUTCHMED, IMG-007, an investigational OX40 antagonistic monoclonal antibody and IMG-004, a reversible, non-covalent, highly selective oral BTK inhibitor designed to target immunological diseases.
Lead Product(s): IMG-007
Therapeutic Area: Dermatology Product Name: IMG-007
Highest Development Status: Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Inmagene Biopharmaceuticals
Deal Size: $455.0 million Upfront Cash: Undisclosed
Deal Type: Licensing Agreement February 02, 2024
Details:
Elunate (fruquintinib) is a selective oral inhibitor of VEGF receptors. It is approved in Hong Kong for the treatment of metastatic colorectal cancer.
Lead Product(s): Fruquintinib
Therapeutic Area: Oncology Product Name: Elunate
Highest Development Status: ApprovedProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable January 29, 2024
Details:
HMPL-523 (sovleplenib) is a novel, selective, oral inhibitor targeting spleen tyrosine kinase (Syk). It is being developed in phase 3 clinical trials for the treatment of hematological malignancies and immune diseases.
Lead Product(s): Sovleplenib
Therapeutic Area: Immunology Product Name: HMPL-523
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable January 10, 2024
Details:
Fruquintinib is a selective oral VEGFR inhibitor it plays a pivotal role in blocking tumor angiogenesis. It being investigated in combination with sintilimab (PD-1 inhibitor) for advanced renal cell carcinoma in China.
Lead Product(s): Fruquintinib,Sintilimab
Therapeutic Area: Oncology Product Name: HMPL-013
Highest Development Status: Phase II/ Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable December 12, 2023
Details:
Elunate (fruquintinib) is a highly selective and potent oral inhibitor of VEGFR -1, -2 and -3. VEGFR inhibitors play a pivotal role in blocking tumor angiogenesis and designed to improve kinase selectivity with the intention of minimizing off-target toxicities.
Lead Product(s): Fruquintinib
Therapeutic Area: Oncology Product Name: Elunate
Highest Development Status: ApprovedProduct Type: Small molecule
Partner/Sponsor/Collaborator: Takeda Pharmaceutical
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 29, 2023
Details:
TAZVERIK® (tazemetostat) is a methyltransferase inhibitor indicated in the United States for the treatment of relapsed/refractory follicular lymphoma.
Lead Product(s): Tazemetostat
Therapeutic Area: Oncology Product Name: Tazverik
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 11, 2023
Details:
Orpathys (savolitinib), is an oral, potent and highly selective MET tyrosine kinase inhibitor that has demonstrated clinical activity in advanced solid tumors.
Lead Product(s): Savolitinib
Therapeutic Area: Oncology Product Name: Orpathys
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 28, 2023
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