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Humanetics
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U.S.A
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7650 Edinborough Way, Suite 620 Edina, MN 55435
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952-937-7660
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Details:

The funding will support a series of studies with its new drug candidate, BIO 300 (genistein), a unique, highly selective modulator of inflammation, cell cycle arrest and DNA damage repair, as a treatment for idiopathic pulmonary fibrosis.


Lead Product(s): Genistein

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: BIO 300

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: National Heart, Lung, and Blood Institute

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Funding October 24, 2023

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The agreement aims to develop Humanetics' drug, BIO 300 (genistein), a unique, highly selective modulator of inflammation, cell cycle arrest and DNA damage repair, as a medical countermeasure to prevent bodily harm caused by acute exposure to radiation.


Lead Product(s): Genistein

Therapeutic Area: Infections and Infectious Diseases Product Name: BIO 300

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: Department of Defense

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement September 06, 2023

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BIO 300 (genistein) is a small molecule drug candidate which increases the killing effect of radiation on multiple tumor thus selectively protect normal tissues and to avoid protection of tumor cells. It is being developed as a treatment of inflammatory pulmonary injury.


Lead Product(s): Genistein

Therapeutic Area: Infections and Infectious Diseases Product Name: BIO 300

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 15, 2023

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BIO 300 (Genistein) Oral Powder is the Company’s medical countermeasure under development to prevent acute radiation syndrome (ARS). The article details results from the trial including safety, pharmacokinetics, and biomarkers in 34 healthy volunteers.


Lead Product(s): Genistein

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: BIO 300

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 15, 2022

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BIO 300 Oral Powder (Genistein) is a new formulation that was developed to address unique operational needs of military personnel and first responders. It is a solid oral dosage formulation that is shelf-stable and can be self-administered.


Lead Product(s): Genistein

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: BIO 300

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 25, 2022

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The new funding will be used to create, manufacture, and test a new formulation of BIO 300 (genistein) that can be self-administered using an auto injector. Auto injectors are commonly used by the military to deliver fast-acting drugs such as atropine and naloxone.


Lead Product(s): Genistein

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: BIO 300

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: U.S. Department of Defense

Deal Size: $5.1 million Upfront Cash: Undisclosed

Deal Type: Funding June 21, 2022

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Details:

BIO 300 (genistein) is an oral drug that patients self-administer daily for 12 weeks following discharge from the hospital. The primary endpoint of the trial is 12 weeks after the start of dosing and patients will be followed for one year.


Lead Product(s): Genistein

Therapeutic Area: Infections and Infectious Diseases Product Name: BIO 300

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 18, 2022

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Details:

BIO 300 is under advanced development by Humanetics as a medical countermeasure to protect healthy human tissues and organs from harm caused by ionizing radiation. BIO 300 was initially discovered by researchers at the U.S.


Lead Product(s): Genistein

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: BIO 300

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 24, 2021

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Details:

The studies will evaluate the potential of BIO 300 to prevent metastasis of triple negative breast cancer to the lungs following radiotherapy.


Lead Product(s): Genistein

Therapeutic Area: Oncology Product Name: BIO 300

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: Regenerative Medicine Minnesota

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Funding June 02, 2021

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Details:

Partnership will support clinical trial studies of BIO 300 in COVID-19 patients.


Lead Product(s): Genistein

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: BIO 300

Highest Development Status: Phase IIProduct Type: Small molecule

Recipient: Pharmaceutics International

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Partnership August 19, 2020

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