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GH Research
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28 Baggot Street Lower, Dublin 2
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GH001, is formulated for mebufotenin (5-MeO-DMT) administration via a proprietary inhalation approach, which is investigated for the treatment of treatment-resistant depression.


Lead Product(s): Mebufotenin

Therapeutic Area: Psychiatry/Psychology Product Name: GH001

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 29, 2023

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GH Research will use the proceeds to support further clinical development of GH001 (5-MeO-DMT) in Treatment-Resistant Depression (TRD) and to advance GH001 into further clinical development in additional psychiatric and neurological disorders.


Lead Product(s): Mebufotenin

Therapeutic Area: Psychiatry/Psychology Product Name: GH001

Highest Development Status: Phase I/ Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: RA Capital

Deal Size: $125.0 million Upfront Cash: Undisclosed

Deal Type: Series B Financing April 13, 2021

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GH001 has the potential to offer an ultra-rapid clearance of symptoms with long-term sustained remission after a single administration session. In the completed Phase 1 healthy volunteer study (GH001-HV-101), GH001 was safe and well-tolerated at the investigated dose levels.


Lead Product(s): Mebufotenin

Therapeutic Area: Psychiatry/Psychology Product Name: GH001

Highest Development Status: Phase I/ Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 19, 2020

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