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Details:
The Company intends to use the proceeds to fund the ongoing clinical development of DYNE-101, an experimental treatment for Duchenne muscular dystrophy and DYNE-251, including the acceleration of activities related to expedited regulatory pathways for DYNE-101 and DYNE-251.
Lead Product(s): DYNE-101
Therapeutic Area: Genetic Disease Product Name: DYNE-101
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Morgan Stanley
Deal Size: $345.1 million Upfront Cash: Undisclosed
Deal Type: Public Offering January 11, 2024
Details:
The Company intends to use the proceeds to fund the ongoing clinical development of DYNE-101, an experimental treatment for Duchenne muscular dystrophy and DYNE-251, including the acceleration of activities related to expedited regulatory pathways for DYNE-101 and DYNE-251.
Lead Product(s): DYNE-101
Therapeutic Area: Genetic Disease Product Name: DYNE-101
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Morgan Stanley
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Public Offering January 03, 2024
Details:
DYNE-101 is an investigational therapeutic which consists of an antisense oligonucleotide conjugated to a fragment antibody (Fab) that binds to the transferrin receptor 1 (TfR1). It is being evaluated in the Phase 1/2 global clinical trial for people living with DM1.
Lead Product(s): DYNE-101
Therapeutic Area: Genetic Disease Product Name: DYNE-101
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable January 03, 2024
Details:
DYNE-101 is an investigational therapeutic being evaluated in the Phase 1/2 global ACHIEVE clinical trial for people living with myotonic dystrophy type 1 (DM1).
Lead Product(s): DYNE-101
Therapeutic Area: Genetic Disease Product Name: DYNE-101
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 20, 2023
Details:
DYNE-101 consists of an antigen-binding Fab conjugated to an ASO and is designed to enable targeted muscle tissue delivery with the goal of reducing toxic DMPK RNA in the nucleus.
Lead Product(s): DYNE-101
Therapeutic Area: Genetic Disease Product Name: DYNE-101
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable May 25, 2023
Details:
DYNE-251 consists of a phosphorodiamidate morpholino oligomer conjugated to a fragment antibody that binds to the TfR1, allowing muscle cells to create functional dystrophin protein. It is being evaluated for duchenne muscular dystrophy who are amenable to exon 51 skipping.
Lead Product(s): DYNE-251
Therapeutic Area: Genetic Disease Product Name: DYNE-251
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 23, 2023
Details:
DYNE-251 consists of a phosphorodiamidate morpholino oligomer conjugated to a fragment antibody that binds to the transferrin receptor 1 (TfR1) which is highly expressed on muscle. DYNE-251 is being developed for people living with DMD who are amenable to exon 51 skipping.
Lead Product(s): DYNE-251
Therapeutic Area: Genetic Disease Product Name: DYNE-251
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 31, 2022
Details:
DYNE-251 demonstrated a favorable safety profile and achieved impressive exon skipping in non-human primates, especially in the heart and diaphragm, muscles in people living with DMD that weaken over time leading to mortality.
Lead Product(s): DYNE-251
Therapeutic Area: Genetic Disease Product Name: DYNE-251
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 11, 2022
Details:
DYNE-101 consists of an antigen-binding fragment antibody conjugated to an antisense oligonucleotide to enable targeted muscle tissue delivery with goal of reducing toxic DMPK RNA in nucleus, releasing splicing proteins.
Lead Product(s): DYNE-101
Therapeutic Area: Genetic Disease Product Name: DYNE-101
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 06, 2022
Details:
DYNE-251 consists of a phosphorodiamidate morpholino oligomer (PMO) conjugated to a fragment antibody (Fab) that binds to the transferrin receptor 1 (TfR1) which is highly expressed on muscle.
Lead Product(s): DYNE-251
Therapeutic Area: Genetic Disease Product Name: DYNE-251
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 06, 2022
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