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BioStem Technologies
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The proceeds will be used to complete clinical trials to support product performance, expand brand awareness and product distribution, including Vendaje Optic (amniotic tissue allograft), a structural tissue allograft composed of the amnion layer of the placental membrane.


Lead Product(s): Amniotic Tissue Allograft

Therapeutic Area: Ophthalmology Product Name: Vendaje Optic

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Undisclosed

Deal Size: $2.0 million Upfront Cash: Undisclosed

Deal Type: Private Placement November 03, 2023

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Under the agreement, NovaBay has been granted the right to commercialize BioStem Technologies’ Vendaje Optic (amniotic tissue allograft) as Avenova® Allograft, which is intended for use as a protective covering during the repair of ocular surfaces.


Lead Product(s): Amniotic Tissue Allograft

Therapeutic Area: Ophthalmology Product Name: Vendaje Optic

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: NovaBay Pharmaceuticals

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement September 11, 2023

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VENDAJE is a structural tissue allograft composed of the dehydrated human amniotic membrane of the placental membrane. VENDAJE is intended for homologous use as a protective covering for soft tissue wounds.


Lead Product(s): Dehydrated Human Amniotic Membrane

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: Vendaje

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 24, 2023

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The study investigates a standardized method to quantify the elution of growth factors and cytokines in BioStem’s dehydrated amniotic membrane (Vendaje®) and dehydrated amnion/chorion (Vendaje AC®) placental derived allografts as a function of surface (cm2).


Lead Product(s): Dehydrated Human Amniotic Membrane

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: Vendaje

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 13, 2022

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The TRIP response indicated that VENDAJE™ does meet the criteria in 21 CFR 1271.10(a) for regulation solely under Section 361 of the Public Health Service Act and 21 CFR 1271.


Lead Product(s): Dehydrated human amniotic membrane allograft

Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: Vendaje

Highest Development Status: ApprovedProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 25, 2021

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