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    Pharma Services Category of DOTTIKON EXCLUSIVE SYNTHESIS AG

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    HTL Biotechnology is the world leader in the responsible development and production of pharmaceutical-grade biopolymers.
    Polpharma is a Polish CDMO of APIs and a significant European API producer, delivering products to companies worldwide.
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    01 API Development (4)

    02 Clinical Supply (1)

    03 Continuous Flow Process (1)

    04 Custom Synthesis & Manufacturing (2)

    05 GMP Manufacturing (1)

    06 Hazardous Chemistry (1)

    07 High Potency APIs (HPAPIs) (1)

    08 High Pressure Reaction (> 100 psi) (1)

    09 Low Temperature / Cryogenic conditions (1)

    10 Scale Up (1)

    11 Separation & Purification (1)

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    01 DOTTIKON EXCLUSIVE SYNTHESIS AG (15)

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    01 Switzerland (15)

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    DOTTIKON EXCLUSIVE SYNTHESIS AG

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    CUSTOM SYNTHESIS AND PROCESS DEVELOPMENT

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    DOTTIKON provides chemical custom manufacturing services to scale up from grams to multi-tons, including routefinding, process design, process development, small-scale and pilot production, manufacturing, qualification and validation.

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    Pharma Service: API Manufacturing

    Category: Custom Synthesis & Manufacturing

    Sub Category: Overview
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    HIGHLY POTENT API (HPAPI) MANUFACTURING

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    To handle active substances, DOTTIKON has state-of-the-art containment concepts on all scales (e.g. closed charging/handling/discharging, full protection suit, monitoring, WIP/CIP cleaning, and cleaning validation).

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    Pharma Service: API Manufacturing

    Category: High Potency APIs (HPAPIs)

    Sub Category: Overview
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    QUALITY MANAGEMENT

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    cGMP and other higher industry quality standards are an integral part of the comprehensive quality system of DOTTIKON EXCLUSIVE SYNTHESIS AG's independent Quality Management department.

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    Pharma Service: API Manufacturing

    Category: GMP Manufacturing

    Sub Category: Overview
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    HAZARDOUS REACTIONS

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    DOTTIKON EXCLUSIVE SYNTHESIS AG is the leading specialist for hazardous reactions, highly exothermic processes, highly reactive compounds, thermally or mechanically unstable compounds or mixtures, and highly active compounds.

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    Pharma Service: API Manufacturing

    Category: Hazardous Chemistry

    Sub Category: Overview
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    LOW-TEMPERATURE PROCESSES

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    DOTTIKON has know-how and low-temperature equipment (glass and Hastelloy) on all scales for batch-wise as well as continuous processing: Research & Development up to 0.5 l and down to –80 °C, Small-scale & Pilot up to 160 l and down to –80 °C, Production

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    Pharma Service: API Manufacturing

    Category: Low Temperature / Cryogenic conditions

    Sub Category: Overview
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    CONDUCTING HIGH-PRESSURE REACTIONS

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    DOTTIKON EXCLUSIVE SYNTHESIS AG offers profound expertise from conducting high-pressure reactions (H2, CO, NO, NH3, HNR2, CO2) over the past 60 years. More than 150 different projects have been scaled up to multi-ton production, including heterogeneous an

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    Pharma Service: API Manufacturing

    Category: High Pressure Reaction (> 100 psi)

    Sub Category: Overview
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    CONTINUOUS PROCESSES FOR HAZARDOUS REACTIONS

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    Dottikon has more than 40 years of experience in continuous flow chemistry reactions using micro and tubular flow reactors. It has the capability to perform fast and hazardous reactions to manufacture hazardous compounds.

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    Pharma Service: API Manufacturing

    Category: Continuous Flow Process

    Sub Category: Overview
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    API MANUFACTURING FOR CLINICAL TRIALS API

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    DOTTIKON's facilities are suited to the clinical manufacturing of chemical intermediates and active pharmaceutical ingredients (APIs) in clinical trials, as well as for marketed small-volume APIs.

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    Pharma Service: API Manufacturing

    Category: Clinical Supply

    Sub Category: Overview
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    cGMP PILOT PLANTS EQUIPPED TO HANDLE HIGH POTENCY PRODU...

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    DOTTIKON meets this demand with three stand-alone, fully qualified cGMP pilot/small-scale plants, equipped to handle high-potency products.

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    Pharma Service: API Manufacturing

    Category: Scale Up

    Sub Category: Overview
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    NINE cGMP MULTI-TON PRODUCTION PLANTS

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    DOTTIKON EXCLUSIVE SYNTHESIS AG has nine cGMP multipurpose and specialized multi-ton production plants including hazardous reactions, high-pressure (50 bar), low-temperature ( 100°C), and continuous processing.

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    Pharma Service: API Manufacturing

    Category: Custom Synthesis & Manufacturing

    Sub Category: Overview
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    ISOLATION TECHNOLOGY & DRYING EQUIPMENTS

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    Isolation technologies and drying equipment is available at all scales and in different materials. All equipment is compliant with cGMP and other higher industry standards.

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    Pharma Service: API Manufacturing

    Category: Separation & Purification

    Sub Category: Extraction & Isolation
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    EXCLUSIVE SYNTHESIS

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    DOTTIKON EXCLUSIVE SYNTHESIS AG provides chemical custom manufacturing services to scale up from grams to multi-tons, including routefinding, process design, process development, small-scale and pilot production, manufacturing, qualification and validatio

    - Directory Listing

    Pharma Service: API & Drug Product Development

    Category: API Development

    Sub Category: Custom Synthesis
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    3 ROUTEFINDING LABS

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    DOTTIKON EXCLUSIVE SYNTHESIS AG dedicates significant resources for rigorous R&D, routefinding and process development.

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    Pharma Service: API & Drug Product Development

    Category: API Development

    Sub Category: Custom Synthesis
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    R&D AND PROCESS DEVELOPMENT

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    DOTTIKON EXCLUSIVE SYNTHESIS AG dedicates significant resources for rigorous R&D, routefinding and process development. Experience in over 2'900 projects and capacity for more than 20 simultaneous projects.

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    Pharma Service: API & Drug Product Development

    Category: API Development

    Sub Category: Custom Synthesis
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    CONTAINMENT OF HIGH POTENCY API (HPAPI)

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    To handle active substances, DOTTIKON has state-of-the-art containment concepts at all scales (e.g. closed charging/handling/discharging, full protection suit, monitoring, WIP/CIP cleaning, and cleaning validation).

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    Pharma Service: API & Drug Product Development

    Category: API Development

    Sub Category: High Potency APIs (HPAPIs)
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