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    Pharma Services Category of Bellen Chemistry

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    HTL Biotechnology is the world leader in the responsible development and production of pharmaceutical-grade biopolymers.
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    01 API Development (9)

    02 Analytical Method Development (3)

    03 Chiral Synthesis (1)

    04 Chromatography (1)

    05 Continuous Flow Process (1)

    06 Fine Chemical / Intermediate (1)

    07 GMP Manufacturing (1)

    08 Hazardous Chemistry (1)

    09 Hydrogenation (1)

    10 Low Temperature / Cryogenic conditions (1)

    11 Lyophilization (1)

    12 Scale Up (1)

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    01 Bellen Chemistry (22)

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    01 China (22)

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    Bellen Chemistry

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      ANALYTICAL METHODS & VALIDATIONS

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      Bellen Chemistry, with experienced teams, state-of-the-art equipment, tools and techniques has over a decade of experiences and successful track records in developing compliant and clinical phase-appropriate analytical methods and validations.

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      Pharma Service: Analytical

      Category: Analytical Method Development

      Sub Category: Method Development and Validation
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      Bellen Chemistry

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        METHOD DEVELOPMENT FOR CHIRAL COMPOUNDS

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        Bellen Chemistry's team has extensive experience in developing methods for chiral compounds, non-chromophoric compounds, and in handling complex sample metrics, high molecular weight substances, structure identification of intermediates & impurities, etc.

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        Pharma Service: Analytical

        Category: Analytical Method Development

        Sub Category: Chiral HPLC & SFC Method Development
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        Bellen Chemistry

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          ANALYTICAL METHOD DEVELOPMENT

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          Bellen Chemistry provides various development services such as analytical method development, commercial route development and scale-up, process control strategy for RSM, intermediates and APIs, process validation & safety assessment, etc.

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          Pharma Service: Analytical

          Category: Analytical Method Development

          Sub Category: Overview
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          Bellen Chemistry

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            BIOCATALYSIS DEVELOPMENT SERVICES

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            Bellen's Chemistry's chemical capabilities include enzyme catalysis, photochemistry, flow chemistry, heterocycles, asymmetric synthesis, natural products, nucleosides & nucleotides, scale up of hazardous reactions, etc.

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            Pharma Service: API & Drug Product Development

            Category: API Development

            Sub Category: Biocatalysis
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            Bellen Chemistry

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              FINE CHEMICALS AND INTERMEDIATES DEVELOPMENT

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              Bellen's development services include preparation of key intermediates, building blocks, design and synthesis of focused libraries, lead optimization and preclinical candidate selection, synthesis of reference compounds, impurity markers, etc.

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              Pharma Service: API & Drug Product Development

              Category: API Development

              Sub Category: Fine Chemical / Intermediate
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              Bellen Chemistry

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                IMPURITY & REFERENCE STANDARD SYNTHESIS

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                Bellen's development service capabilities include synthesis of reference compounds, impurity markers, preparation of key intermediates, building blocks, design and synthesis of focused libraries, lead optimization and preclinical candidate selection, etc.

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                Pharma Service: API & Drug Product Development

                Category: API Development

                Sub Category: Impurity / Reference Standard
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                Bellen Chemistry

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                  PHOTOCHEMISTRY SERVICES

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                  Bellen is exploring & practicing one the green technologies such as photochemistry to provide the various advantages like high efficiency with fewer side reactions, cost-effective, flexible, potential coupling with flow chemistry, etc.

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                  Pharma Service: API & Drug Product Development

                  Category: API Development

                  Sub Category: Photochemistry
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                  Bellen Chemistry

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                    PROCESS DEVELOPMENT & OPTIMIZATION SERVICES

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                    Bellen's R&D Center- at Shanghai, China, offers process research & development services. They deliver projects involving complex chemical synthesis from route scouting, process development, process optimization and scale-up to commercial scale.

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                    Pharma Service: API & Drug Product Development

                    Category: API Development

                    Sub Category: Process Development & Optimization
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                    Bellen Chemistry

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                      PROCESS SAFETY ASSESSMENT SERVICES

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                      Bellen's fully-equipped process safety laboratories and their dedicated process safety assessment teams, offer full consideration & evaluation of thermal hazard, reaction hazard, operation hazard, etc.

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                      Pharma Service: API & Drug Product Development

                      Category: API Development

                      Sub Category: Process Safety Assessment
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                      Bellen Chemistry

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                        ROUTE DEVELOPMENT & OPTIMIZATION SERVICES

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                        Bellen's dedicated process development team, with the integrated one-stop process development platform offers various key services in route development, optimization such as commercial route development and scale-up, commercial route optimization, etc.

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                        Pharma Service: API & Drug Product Development

                        Category: API Development

                        Sub Category: Route Evaluation & Development
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                        Bellen Chemistry

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                          ROUTE SCOUTING SERVICES

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                          Bellen's flagship process R&D center located at Shanghai, China, delivers projects involving complex chemical synthesis from route scouting, process development, process optimization and scale-up to commercial scale.

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                          Pharma Service: API & Drug Product Development

                          Category: API Development

                          Sub Category: Route Scouting
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                          Bellen Chemistry

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                            SCALE-UP CAPABILITIES

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                            Bellen Chemistry offers phase-appropriate development, scale up & manufacturing services of pre-clinical & phase one NCEs with the advanced technological capabilities for more efficient scale-up of complex chemistries from laboratory to commercial scales.

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                            Category: API Development

                            Sub Category: Scale-Up Capabilities
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                            Bellen Chemistry

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                              CHIRAL SYNTHESIS SERVICES

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                              Bellen Chemistry's key manufacturing services include chiral synthesis (Enantio-selective synthesis), custom synthesis of reference compounds, preparation of building blocks, preparation of key intermediates, etc.

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                              Pharma Service: API Manufacturing

                              Category: Chiral Synthesis

                              Sub Category: Overview
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                              Bellen Chemistry

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                                CHROMATOGRAPHY SERVICES

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                                Bellen Chemistry manufacturing capabilities include commercial chromatography capabilities & lyophilization, hydrogenation, cryogenics, reactor sizes of 200L to 5000L to accommodate varying reaction volumes and concentrations, etc.

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                                Pharma Service: API Manufacturing

                                Category: Chromatography

                                Sub Category: Overview
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                                Bellen Chemistry

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                                  FLOW CHEMISTRY SERVICES

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                                  Bellen's flow chemistry service offers enhanced operational safety and efficiency whilst driving down costs and increasing value. They utilise flow reactors to run processes in a continuous manner, contrary to the conventional batch mode of operation.

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                                  Pharma Service: API Manufacturing

                                  Category: Continuous Flow Process

                                  Sub Category: Overview
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                                  Bellen Chemistry

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                                    CONTRACT MANUFACTURING FOR KEY INTERMEDIATES

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                                    Bellen manufacturing plant at shandong, delivers key intermediates & cGMP API manufacturing services for early phase and late phase projects. The facility has a capacity of 100KL with manufacturing blocks into groups to achieve maximum flexibility.

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                                    Pharma Service: API Manufacturing

                                    Category: Fine Chemical / Intermediate

                                    Sub Category: Overview
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                                    Bellen Chemistry

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                                      cGMP API MANUFACTURING

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                                      Bellen manufacturing plant at shandong, delivers cGMP APIs & key intermediates manufacturing services for early phase and late phase projects. The facility has a capacity of 100KL with manufacturing blocks into groups to achieve maximum flexibility.

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                                      Pharma Service: API Manufacturing

                                      Category: GMP Manufacturing

                                      Sub Category: Active Pharmaceutical Ingredients
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                                      Bellen Chemistry

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                                        HAZARDOUS REACTION SERVICES

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                                        Bellen's API manufacturing capabilities include, scale up of hazardous reaction (diazo, oxidization, curtius rearrangement etc), heterocycles, asymmetric synthesis, natural products, nucleosides & nucleotides, photochemistry, flow chemistry, etc.

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                                        Pharma Service: API Manufacturing

                                        Category: Hazardous Chemistry

                                        Sub Category: Overview
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                                        Bellen Chemistry

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                                          HYDROGENATION CAPABILITIES

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                                          Bellen Chemistry's manufacturing plant in Shandong, China, utilize hydrogenators ranging from 100L to 2000L that operate up to 50 bar and also cryogenic reactors with an operating range down to -78 °C. Their current reactor volume is ~100m3.

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                                          Pharma Service: API Manufacturing

                                          Category: Hydrogenation

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                                            CRYOGENIC REACTIONS

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                                            Bellen Chemistry's manufacturing plant in Shandong, China, utilize cryogenic reactors with an operating range down to -78 °C & hydrogenators ranging from 100L to 2000L that operate up to 50 bar. Their current reactor volume is ~100m3.

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                                            Pharma Service: API Manufacturing

                                            Category: Low Temperature / Cryogenic conditions

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                                              LYOPHILLIZATION CAPABILITIES

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                                              Bellen’s world-class manufacturing facility is equipped with a flexible and versatile infrastructure with various capabilities such as lyophilization, hydrogenation, cryogenics and commercial chromatography capabilities, etc.

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                                              Pharma Service: API Manufacturing

                                              Category: Lyophilization

                                              Sub Category: Overview
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                                                SCALE-UP SERVICES

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                                                Bellen Chemistry supports innovator companies with quick and effective services in phase-appropriate development, scale up and manufacturing of pre-clinical and phase one NCEs.

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                                                Category: Scale Up

                                                Sub Category: Overview
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