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    Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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    About

    We create chemistry for a sustainable future. In line with our corporate purpose, around 112,000 employees contribute to the success of our customers in nearly all sectors and almost every country in the world. Our broad portfolio ranges from chemicals, plastics, performance products and crop protection products to oil and gas. In 2015, BASF posted sales of €70 billion and income from operations before special items of app...
    We create chemistry for a sustainable future. In line with our corporate purpose, around 112,000 employees contribute to the success of our customers in nearly all sectors and almost every country in the world. Our broad portfolio ranges from chemicals, plastics, performance products and crop protection products to oil and gas. In 2015, BASF posted sales of €70 billion and income from operations before special items of approximately €6.7 billion. We combine economic success with environmental protection and social responsibility. Through research and innovation, we support our customers in nearly every industry.

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    INTERVIEW #SpeakPharma

    [Sponsored by another company]
    “We have built considerable expertise in GLP-1 drug development through our oral peptide programs”

    “We have built considerable expertise in GLP-1 drug development through our oral peptide programs”

    This week, Speak Pharma interviews Dr. Andrew Lewis, Chief Scientific Officer at Quotient Sciences, a drug development and manufacturing accelerator that offers a range of integrated programs and tailored services to over 550 customers. Lewis discusses the latest developments in the delivery of oral peptides and how Quotient Sciences is helping customers overcome drug development challenges in this exciting space. 🔑HIGHLIGHTS// latest developments in the delivery of oral peptides Why have glucagon-like peptide-1 (GLP-1) therapies become essential for treating type 2 diabetes and obesity? What makes the oral delivery of peptides such as GLP-1 challenging? GLP-1 and gastric inhibitory polypeptide (GIP) are essential incretin hormones involved in regulating glucose metabolism. Both are produced in the gastrointestinal (GI) tract in response to food intake, specifically glucose and fats. GLP-1 enhances insulin secretion from the pancreas, but only in response to elevated blood glucose levels. GIP has overlapping effects that are slightly contradictory – it promotes the production of glucagon, which can counteract its glucose-lowering effects. In people with type 2 diabetes, the body’s response to incretin hormones is impaired. However, the GLP-1 pathway remains relatively intact, allowing it to still stimulate insulin production. There is a more significant impairment for GIP, making it not as effective. This makes GLP-1 a more attractive target for treatment, leading to the development of several GLP-1 receptor agonists for managing type 2 diabetes, obesity, and potentially other conditions. Incretin analogs, like GLP-1 agonists, have traditionally been challenging to deliver orally. As a result, these medications are most often given by injection. But we know that patients generally prefer taking a tablet or capsule treatment rather than an injection. Peptides such as GLP-1 analogs go through a challenging journey before being absorbed. This is because the gastrointestinal tract functions to digest these into either small amino acids or very short pieces of polypeptides. Even if they get to the epithelium, they tend to have poor permeability, usually resulting in less than 1 percent bioavailability (the proportion of a drug that enters the circulatory system when introduced into the body, thereby having an active effect). Various technologies have been developed to overcome bioavailability issues, with permeation enhancers being the most advanced and validated. For example, SNAC is the permeation enhancer used in Novo Nordisk’s oral pill Rybelsus to promote semaglutide absorption. Mycapssa (octreotide capsules), marketed by Chiesi, employs the Transient Permeation Enhancer (TPE) technology, which utilizes the medium-chain fatty acid (MCFA) sodium caprylate (C8) to augment the absorption of the somatostatin analog octreotide. At Quotient Sciences, over the last decade, we’ve worked on over 14 oral peptide programs and tested about a dozen different permeation enhancer combinations with them. Permeation enhancers tend to be required in large amounts in formulations, and many of them are usually waxy materials with poor flow, so the tablet formulation and manufacturing process require extra attention and careful design. From an analytics perspective, a lot of the standard quality control tests for tablets have been designed for small-molecule drugs and are yet to be optimized for use with peptides. 🔑HIGHLIGHTS// permeation enhancers as the most advanced and validated technology to overcome bioavailability issues/ worked on over 14 oral peptide programs/ tested about a dozen different permeation enhancer combinations How does Quotient Sciences handle the transition from pre-clinical to clinical development? We’ve pioneered an integrated approach through our Translational Pharmaceutics platform for drug development. This platform combines drug product manufacturing with clinical testing in healthy volunteers, allowing us to be incredibly adaptive in our phase I trial design. Through a tight integration of services, we can manufacture a drug, dose it in healthy volunteers, perform bioanalysis and pharmacokinetic analysis, and use data in real time to inform our next steps. In oral peptide programs, we’ve performed numerous studies where we’ve used this capability to optimize the formulation in response to the clinical data. Typical variables we’ve evaluated are the dose of the peptide and the levels of a permeation enhancer, allowing us to identify the relationship between them to maximize human bioavailability. Through our ability to see the full spectrum of data – from preclinical to clinical – for 11 different peptides and 10 different permeation enhancers, we have built up considerable expertise in the development of oral peptide drug products. This allows us to provide a more streamlined drug development process for our clients, as common challenges across programs can be readily overcome. 🔑HIGHLIGHTS// Translational Pharmaceutics platform for drug development/ combine drug product manufacturing with clinical testing in healthy volunteers/ use data in real time to inform next steps/ 11 different peptides and 10 different permeation enhancers What innovations do you see ahead for oral peptide delivery? I see a real convergence in advances in peptide drug discovery and engineering, together with advances in drug delivery that are really pushing the field forward. Technologies such as phage display mean that vast libraries of peptides can be screened for properties of interest. These are being applied to design peptides specifically for oral delivery. From a drug delivery perspective, approaches such as ingestible devices, ionic liquids and various technologies to exploit active uptake mechanisms are showing real promise. One challenge with oral peptide delivery technologies is that their effectiveness can be significantly impacted by food intake. However, I expect that in the coming years, new methods will be developed to mitigate these food-related effects. I also expect artificial intelligence (AI) to greatly benefit oral peptide delivery. In 2021, the US Food and Drug Administration reported it saw more than 100 drug and biologic application submissions containing elements of AI or machine learning (ML) used in the development process. So three to four years later, that number has likely only increased. All these developments promise to make oral peptide therapies more effective and convenient for patients in the years to come. 🔑HIGHLIGHTS// phage display to screen vast libraries of peptides for properties of interest/ ingestible devices, ionic liquids and various technologies to exploit active uptake mechanisms/ AI will greatly benefit oral peptide delivery To learn more about this topic, watch Quotient Sciences’ latest webinar featuring Dr. Andrew Lewis and Dr. Stuart Mair, Chief Medical Officer at Quotient Sciences. Watch it here.

    Impressions: 1098

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    #SpeakPharma With Quotient Sciences
    14 Oct 2024
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    VLOG #PharmaReel

    [Sponsored by another company]

    DATA COMPILATION #PharmaFlow

    [Sponsored by another company]
    US, Europe turn to advanced manufacturing, stockpiling to strengthen drug supply chains

    US, Europe turn to advanced manufacturing, stockpiling to strengthen drug supply chains

    Over the last few decades, the United States and Europe have saved trillions of dollars by importing drugs from countries like China and India. Their journey wasn’t easy, with regulatory non-compliance and drug patent scams raising their ugly heads every now and then. The Covid-19 pandemic and the accompanying lockdowns were a wake-up call for these countries to take a long, hard look at their sourcing strategies.Over the last few years, both the US and Europe have embarked on policy changes and ambitious programs to strengthen their drug supply chains. PharmaCompass takes you through US and Europe’s journeys towards more robust pharmaceutical supply chains.Biden’s executive order, CARES Act, state-backed investments strengthen US supply chainDuring the early days of the pandemic, the US government (under former President Donald Trump)  had enacted the Coronavirus Aid, Relief, and Economic Security Act (CARES Act) to address the economic fallout of the pandemic through a US$ 2.2 trillion stimulus. Through this act, the FDA had taken several drug shortage mitigation efforts. The new administration under President Joe Biden undertook more measures. Notable amongst them was Executive Order 14017 on America’s supply chains. It mandated a comprehensive 100-day review to identify vulnerabilities in key sectors, including pharmaceuticals and active pharmaceutical ingredients (APIs). The review noted that 87 percent of generic API facilities are located overseas, leaving the US healthcare system vulnerable to shortages of essential medicines.Through a Presidential Determination, Biden had also broadened US Department of Health and Human Services’ (HHS) authorities under the Defense Production Act (DPA) of 1950. HHS can now enable investment in domestic manufacturing of essential medicines and medical countermeasures under the DPA. The HHS has invested US$ 17 billion in domestic manufacturing for the medical supply chain, including US$ 500 million to support API manufacturing.Under this effort, Merck has been awarded a €121 million (US$ 132 million) government contract to set up a lateral flow membrane production facility at Sheboygan, Wisconsin. Similarly, California has launched an initiative (known as CalRx) and is working with CIVICA to make US$ 30 insulin available to all who need it.Europe encourages reshoring; EDQM develops monographs for unlicensed alternativesIn recent years, Europe has faced shortages of insulin, antibiotics, oncology drugs, corticosteroids and even paracetamol. To overcome these shortages, the European Medicines Agency (EMA) is encouraging drugmakers to enhance manufacturing capacity and diversify suppliers.There is change visible on the ground. Companies like Midas Pharma, EUROAPI, Seqens are setting up API plants in Europe. Seqens has taken steps to reshore paracetamol production in France and is constructing a new € 100 million (US$ 109 million) production unit in Roussillon. Sanofi is investing €1.3 billion (US$ 1.4 billion) in a new insulin production facility at its existing site in Frankfurt. Similarly, Sandoz has set up a new antibiotic production plant in Austria and a new biosimilar development center in Germany.That said, we know that manufacturing capacities take time to build and are often financially unviable in the developed world. Ergo, a particularly innovative initiative has come from the European Directorate for the Quality of Medicines & HealthCare (EDQM). Their project aims to develop monographs detailing the preparation and testing of unlicensed drugs that can fill the gap left when licensed medicinal products are unavailable. To facilitate this initiative, the European Pharmacopoeia Commission is recruiting experts to verify proposed production methods and analytical procedures.The other means of guarding against supply and demand fluctuations is stockpiling. The EMA has advised the European Commission (EC) and marketing authorization holders (MAH) to stockpile medicines. The regulator has also asked MAHs to establish a shortage prevention plan for critical medicines. Europe’s Health Emergency Response Authority (HERA) is taking a systematic approach to stockpile management.Despite these measures, costs and market structures pose serious challenges. Medicines for Europe, representing the generic and biosimilar medicines industry, has raised concerns about the current market structures. They argue that government purchasing practices, which prioritize obtaining the lowest prices for off-patent medicines, are jeopardizing the European manufacturing footprint and discouraging investments in supply chain resilience.FDA, EMA promote continuous manufacturing; US relies on digital stockpilesDuring the pandemic, there were acute shortages of oncology, cardiovascular, anesthesia, anti-infective, neurological and anti-allergic drugs in the US. A 2022 study undertaken by the Washington University points out that there is excess manufacturing capacity in the US that can be considered for reshoring critical and essential drugs. In fact, 49 percent of generic drug manufacturing capacity in the US is lying idle, and many others are working at less than 50 percent capacity. These capacities can be repurposed. Various advanced manufacturing technologies, such as  “continuous flow and on-demand manufacturing capabilities in idled manufacturing sites offer the ability to reduce production cost,” says this report.FDA has been promoting “advanced manufacturing” technologies, such as continuous manufacturing, which are now a part of America’s overall strategy to strengthen and secure the pharmaceutical supply chain. The EMA has also released guidelines on continuous manufacturing of drug substances and drug products. Advanced manufacturing is a collective term for new or innovative medical product manufacturing technologies. Unlike batch manufacturing, which involves sequential processing and testing of material across multiple discrete stages (and often discrete facilities), continuous manufacturing combines the full manufacturing stream into a single, fully integrated flow. While continuous manufacturing may not be suitable for every drug manufacturing process, but where applicable, it tends to eliminate built-in production gaps and shortens the time taken to manufacture a drug from months to days.In the US, the Strategic National Stockpile (SNS) plays a critical role in ensuring the availability of essential medical supplies during emergencies. It now also involves a digital stockpile that does not store physical goods and products. Instead, it stores electronic plans, instructions, and methods to make and test medical products. Digital stockpiles rely on one or more trusted suppliers that can make the product from the digital information, either through methods like 3D printing or self-contained distributed manufacturing lines.Our viewThe global pharmaceutical supply chain is a complex web spanning multiple countries and continents. While advanced manufacturing and stockpiling may work to an extent, a large chunk of generic drugs and APIs will continue to come from countries like China and India.In order to reduce reliance on China, the US has been proactively expanding its collaboration with India. But this time, there is increased emphasis on quality control. While FDA is increasing the number of inspections at Indian drug plants, the Indian government, on its part, has revised rules for drug manufacturing, with higher GMP standards.Taken together, a multi-pronged approach to addressing supply chain vulnerabilities should secure drug supplies to the US and Europe in the years to come.  
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    Impressions: 472

    https://www.pharmacompass.com/radio-compass-blog/us-europe-turn-to-advanced-manufacturing-stockpiling-to-strengthen-drug-supply-chains

    #Phispers by PHARMACOMPASS
    17 Oct 2024
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    NEWS #PharmaBuzz

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    BASF to prepare agricultural business for IPO, Bloomberg reports
    BASF to prepare agricultural business for IPO, Bloomberg reports

    18 Sep 2024

    // REUTERS

    https://www.reuters.com/markets/europe/basf-expected-announce-listing-plans-agri-chemicals-division-reports-bloomberg-2024-09-18/

    REUTERS
    18 Sep 2024
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    German chemical sector employers, union agree 6.85% pay hike over 20 months
    German chemical sector employers, union agree 6.85% pay hike over 20 months

    27 Jun 2024

    // REUTERS

    https://www.reuters.com/markets/commodities/german-chemical-sector-employers-union-agree-685-pay-hike-over-20-months-2024-06-27/

    REUTERS
    27 Jun 2024
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    Signet, BASF organize Formulator’s Forum: Exchange Excipients Innovation in Hyd
    Signet, BASF organize Formulator’s Forum: Exchange Excipients Innovation in Hyd

    08 Apr 2024

    // PHARMABIZ

    https://www.pharmabiz.com/NewsDetails.aspx?aid=168392&sid=2

    PHARMABIZ
    08 Apr 2024
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    Launch of cooperation with BASF Pharma Solutions ZoomLab™
    Launch of cooperation with BASF Pharma Solutions ZoomLab™

    02 Feb 2023

    // PRESS RELEASE

    https://www.midas-pharma.com/en/latest-activities/cooperation-with-basf-zoomlab/

    PRESS RELEASE
    02 Feb 2023
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    Evonik & BASF partner to reduce the envirntal footprint for feed animal protein
    Evonik & BASF partner to reduce the envirntal footprint for feed animal protein

    20 Sep 2022

    // PRESS RELEASE

    https://animal-nutrition.evonik.com/en/evonik-and-basf-partner-to-reduce-the-environmental-footprint-for-feed-and-animal-protein-industries-177866.html

    PRESS RELEASE
    20 Sep 2022
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    BASF Adopts BrightSpec's Broadband MRR Technology for Structural Elucidation
    BASF Adopts BrightSpec's Broadband MRR Technology for Structural Elucidation

    14 Sep 2021

    // PRNEWSWIRE

    https://www.prnewswire.com/news-releases/basf-adopts-brightspecs-broadband-mrr-technology-for-structural-elucidation-301376450.html

    PRNEWSWIRE
    14 Sep 2021
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    ALL APIs

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    01

    Ibuprofen

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AAPS 2024
    Not Confirmed
    arrow

    Ibuprofen

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
    USDMF arrow-down Click Us! arrow-down
    ✖

    GDUFA

    DMF Review : Reviewed

    Rev. Date : 2013-02-05

    Pay. Date : 2013-01-24

    DMF Number : 8709

    Submission : 1990-09-10

    Status : Active

    Type : II

     CEP/COS arrow-down
    ✖

    Certificate Number : R1-CEP 2000-087 - Rev 03

    Issue Date : 2018-12-07

    Type : Chemical

    Substance Number : 721

    Status : Valid

     JDMF arrow-down
    ✖

    Registration Number : 217MF10984

    Registrant's Address : 100 Park Avenue, Florham Park, New Jersey, 07932, United States of America

    Initial Date of Registration : 2005-11-21

    Latest Date of Registration :

    EU-WC NDC arrow-down
    ✖

    NDC Package Code : 10117-0926

    Start Marketing Date : 2010-06-08

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (1kg/kg)

    Marketing Category : BULK INGREDIENT

    KDMF arrow-down
    ✖

    Registrant Name : CTC Bio Co., Ltd.

    Registration Date : 2022-07-25

    Registration Number : 20220725-209-J-1335

    Manufacturer Name : BASF Corporation

    Manufacturer Address : Highway 77 South, Bishop, Texas 78343 (5738 County Road 4, Bishop, Texas 78343) USA

     VMF Others AUDIT
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    02

    Povidone-Iodine

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AAPS 2024
    Not Confirmed
    arrow

    Povidone-Iodine

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 3017

    Submission : 1977-07-22

    Status : Active

    Type : II

     CEP/COS arrow-down
    ✖

    Certificate Number : R1-CEP 2008-179 - Rev 00

    Issue Date : 2015-10-21

    Type : Chemical

    Substance Number : 1142

    Status : Valid

     JDMF arrow-down
    ✖

    Registration Number : 217MF10985

    Registrant's Address : 100 Park Avenue, Florham Park, New Jersey, 07932, United States of America

    Initial Date of Registration : 2005-11-21

    Latest Date of Registration :

    EU-WC NDC arrow-down
    ✖

    NDC Package Code : 70177-0002

    Start Marketing Date : 2010-01-11

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (1kg/kg)

    Marketing Category : BULK INGREDIENT

    KDMF VMF Others AUDIT
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    03

    Riboflavin

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AAPS 2024
    Not Confirmed
    arrow

    Riboflavin

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
    USDMF Inactive-api
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 4407

    Submission : 1981-11-25

    Status : Inactive

    Type : II

     CEP/COS arrow-down
    ✖

    Certificate Number : R1-CEP 2011-069 - Rev 00

    Issue Date : 2017-11-07

    Type : Chemical

    Substance Number : 292

    Status : Valid

     JDMF arrow-down
    ✖

    Registration Number : 228MF10235

    Registrant's Address : 14-16F KCCI Bldg. , 39, Sejongdaero, Jung-gu, Seoul, Republic of Korea

    Initial Date of Registration : 2016-12-26

    Latest Date of Registration :

    EU-WC NDC KDMF VMF Others AUDIT
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    04

    Icosapent Ethyl

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AAPS 2024
    Not Confirmed
    arrow

    Icosapent Ethyl

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : Reviewed

    Rev. Date : 2020-11-02

    Pay. Date : 2020-10-20

    DMF Number : 23911

    Submission : 2010-07-07

    Status : Active

    Type : II

     CEP/COS JDMF arrow-down
    ✖

    Registration Number : 223MF10118

    Registrant's Address : 4th and 5th Floors, 2 Stockport Exchange, Railway Road, Stockport, SK1 3GG, UK

    Initial Date of Registration : 2011-07-25

    Latest Date of Registration :

    EU-WC NDC KDMF VMF Others AUDIT
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    05

    Levomenthol

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AAPS 2024
    Not Confirmed
    arrow

    Levomenthol

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : Reviewed

    Rev. Date : 2020-08-26

    Pay. Date : 2020-06-08

    DMF Number : 26711

    Submission : 2012-12-03

    Status : Active

    Type : II

     CEP/COS arrow-down
    ✖

    Certificate Number : R1-CEP 2012-390 - Rev 01

    Issue Date : 2021-06-16

    Type : Chemical

    Substance Number : 619

    Status : Valid

     JDMF EU-WC NDC arrow-down
    ✖

    NDC Package Code : 48041-0001

    Start Marketing Date : 2014-07-01

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (1kg/kg)

    Marketing Category : BULK INGREDIENT

    KDMF VMF Others AUDIT
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    06

    Omega-3-Acid Ethyl Esters 90

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AAPS 2024
    Not Confirmed
    arrow

    Omega-3-Acid Ethyl Esters 90

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
    USDMF CEP/COS arrow-down
    ✖

    Certificate Number : R1-CEP 2008-132 - Rev 04

    Issue Date : 2020-01-21

    Type : Chemical

    Substance Number : 1250

    Status : Valid

     JDMF arrow-down
    ✖

    Registration Number : 223MF10051

    Registrant's Address : Lilleakerveien 2B, NO-0283 Oslo, Norway P. O. Box 420, NO-1327 Lysaker, Norway

    Initial Date of Registration : 2011-04-12

    Latest Date of Registration :

    EU-WC NDC KDMF arrow-down
    ✖

    Registrant Name : BASF Korea Ltd.

    Registration Date : 2012-12-27

    Registration Number : No. 6246-1-ND

    Manufacturer Name : BASF Pharma (Callanish) Ltd

    Manufacturer Address : Breasclete, Callanish, Isle of Lewis, HS2 9ED, Scotland

     VMF Others AUDIT
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    07

    Vitamin E

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AAPS 2024
    Not Confirmed
    arrow

    Vitamin E

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
    USDMF Inactive-api
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 5826

    Submission : 1985-05-06

    Status : Inactive

    Type : II

     CEP/COS arrow-down
    ✖

    Certificate Number : R1-CEP 2005-039 - Rev 02

    Issue Date : 2023-06-30

    Type : Chemical

    Substance Number : 692

    Status : Valid

     JDMF EU-WC NDC KDMF VMF Others AUDIT
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    08

    Vitamin E Acetate

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AAPS 2024
    Not Confirmed
    arrow

    Vitamin E Acetate

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    USDMF Inactive-api
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 5818

    Submission : 1985-05-06

    Status : Inactive

    Type : II

     CEP/COS JDMF arrow-down
    ✖

    Registration Number : 217MF10983

    Registrant's Address : Carl-Bosch-Strasse 38,67056 Ludwigshafen, Federal Republic of Germany

    Initial Date of Registration : 2005-11-21

    Latest Date of Registration :

    EU-WC NDC KDMF VMF Others AUDIT
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    09

    Azelaic Acid

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AAPS 2024
    Not Confirmed
    arrow

    Azelaic Acid

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 11615

    Submission : 1995-08-04

    Status : Active

    Type : II

     CEP/COS JDMF EU-WC NDC arrow-down
    ✖

    NDC Package Code : 48041-4700

    Start Marketing Date : 2013-01-01

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (1kg/kg)

    Marketing Category : BULK INGREDIENT

    KDMF VMF Others AUDIT
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    10

    Octocrylene

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    AAPS 2024
    Not Confirmed
    arrow

    Octocrylene

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    AAPS 2024
    Not Confirmed
    • fda
    • EDQM
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    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 12600

    Submission : 1997-07-17

    Status : Active

    Type : II

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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    Only 10 entries up to this point, click to access all click full view read-more
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    USDMF

    read-more
    read-more

    01

    5-ethenyl-pyrrolidin-2-one

    Germany
    34th IFSCC
    Not Confirmed
    arrow

    02

    7,-8-didehydro-retinoic Acid

    Germany
    34th IFSCC
    Not Confirmed
    arrow

    03

    9-z-isotretinoin

    Germany
    34th IFSCC
    Not Confirmed
    arrow

    04

    Acetaminophen

    Germany
    34th IFSCC
    Not Confirmed
    arrow

    05

    Acetohexamide

    Switzerland
    34th IFSCC
    Not Confirmed
    arrow

    06

    Acitretin

    34th IFSCC
    Not Confirmed
    arrow

    07

    Allopurinol

    Switzerland
    34th IFSCC
    Not Confirmed
    arrow

    08

    Amsacrine

    Switzerland
    34th IFSCC
    Not Confirmed
    arrow

    09

    Ascorbic Acid

    Germany
    34th IFSCC
    Not Confirmed
    arrow

    10

    Beta-carotene (25mg.) Soft Gelatin C...

    Germany
    34th IFSCC
    Not Confirmed
    arrow
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    CEP/COS

    read-more
    read-more

    01

    Acitretin

    CEP/COS

    34th IFSCC
    Not Confirmed
    arrow

    02

    all-rac-alpha-Tocopherol

    CEP/COS

    34th IFSCC
    Not Confirmed
    arrow

    03

    all-rac-alpha-Tocopheryl acetate

    CEP/COS

    34th IFSCC
    Not Confirmed
    arrow

    04

    Ascorbic acid

    CEP/COS

    34th IFSCC
    Not Confirmed
    arrow

    05

    Ascorbic acid

    CEP/COS

    34th IFSCC
    Not Confirmed
    arrow

    06

    Calcium ascorbate dihydrate

    CEP/COS

    34th IFSCC
    Not Confirmed
    arrow

    07

    Calcium Pantothenate

    CEP/COS

    34th IFSCC
    Not Confirmed
    arrow

    08

    Copovidone, Nominal K-value 28

    CEP/COS

    34th IFSCC
    Not Confirmed
    arrow

    09

    Dexpanthenol

    CEP/COS

    34th IFSCC
    Not Confirmed
    arrow

    10

    Ibuprofen

    CEP/COS

    34th IFSCC
    Not Confirmed
    arrow
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    Excipients

    Click here to find the perfect excipient manufacturers by their capabilities

    All Excipients

    read-more
    read-more

    01

    Crospovidone

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    34th IFSCC
    Not Confirmed
    arrow

    Crospovidone

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    34th IFSCC
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    USDMF arrow-down Click Us! arrow-down
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 2855

    Submission : 1977-02-08

    Status : Active

    Type : IV

     CEP/COS arrow-down
    ✖

    Certificate Number : R1-CEP 2007-076 - Rev 01

    Issue Date : 2015-06-26

    Type :

    Substance Number :

    Status : Valid

     JDMF EU-WC NDC KDMF VMF Others AUDIT
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    02

    N-Vinyl-2-Pyrrolidone

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    34th IFSCC
    Not Confirmed
    arrow

    N-Vinyl-2-Pyrrolidone

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    34th IFSCC
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 22604

    Submission : 2009-01-19

    Status : Active

    Type : IV

     CEP/COS arrow-down
    ✖

    Certificate Number : R1-CEP 2007-106 - Rev 03

    Issue Date : 2020-09-08

    Type :

    Substance Number :

    Status : Valid

     JDMF EU-WC NDC KDMF VMF Others AUDIT
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    03

    Povidone

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    34th IFSCC
    Not Confirmed
    arrow

    Povidone

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    34th IFSCC
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 32695

    Submission : 2018-03-27

    Status : Active

    Type : IV

     CEP/COS arrow-down
    ✖

    Certificate Number : R1-CEP 2007-077 - Rev 02

    Issue Date : 2017-01-30

    Type :

    Substance Number :

    Status : Valid

     JDMF EU-WC NDC KDMF VMF Others AUDIT
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    Market
    Place

    04

    Cocoyl Caprylocaprate

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    34th IFSCC
    Not Confirmed
    arrow

    Cocoyl Caprylocaprate

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    34th IFSCC
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 16496

    Submission : 2003-03-25

    Status : Active

    Type : IV

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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    Market
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    05

    Isopropyl Myristate

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    34th IFSCC
    Not Confirmed
    arrow

    Isopropyl Myristate

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    34th IFSCC
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 16498

    Submission : 2003-03-25

    Status : Active

    Type : IV

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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    Market
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    06

    Medium Chain Triglycerides Excipien...

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    34th IFSCC
    Not Confirmed
    arrow

    Medium Chain Triglycerides Excipien...

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    34th IFSCC
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 16495

    Submission : 2003-03-25

    Status : Active

    Type : IV

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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    Market
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    07

    Methacrylic Acid - Ethyl Acrylate C...

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    34th IFSCC
    Not Confirmed
    arrow

    Methacrylic Acid - Ethyl Acrylate C...

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    34th IFSCC
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 14823

    Submission : 2000-04-11

    Status : Active

    Type : IV

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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    Market
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    08

    Octyldodecanol

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    34th IFSCC
    Not Confirmed
    arrow

    Octyldodecanol

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    34th IFSCC
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 16494

    Submission : 2003-03-25

    Status : Active

    Type : IV

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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    Market
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    09

    Oleyl Alcohol

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    34th IFSCC
    Not Confirmed
    arrow

    Oleyl Alcohol

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    34th IFSCC
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 16497

    Submission : 2003-03-25

    Status : Active

    Type : IV

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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    Market
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    10

    Polyvinyl Acetate

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    34th IFSCC
    Not Confirmed
    arrow

    Polyvinyl Acetate

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    34th IFSCC
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 15055

    Submission : 2000-09-20

    Status : Active

    Type : IV

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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    Excipients by Ingredients

    Upload your portfolio for free, ask us

    Poloxamer 407

    read-more
    read-more

    01

    Brand Name : Kolliphor P407

    Germany

    arrow
    34th IFSCC
    Not Confirmed

    02

    Brand Name : Kolliphor P407 micro

    Germany

    arrow
    34th IFSCC
    Not Confirmed
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    Excipients By applications

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    Inspections and registrations

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    ABOUT THIS PAGE

    Contact BASF and get a quotation

    BASF is a supplier offers 50 products (APIs, Excipients or Intermediates).

    Find a price of Ibuprofen bulk with DMF, CEP, JDMF offered by BASF

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    Find a price of Levomenthol bulk with DMF, CEP offered by BASF

    Find a price of Vitamin E bulk with CEP offered by BASF

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    Find a price of Detalan bulk with DMF offered by BASF

    Find a price of Ibuprofen bulk with DMF offered by BASF

    Find a price of Ibuprofen Sodium bulk with DMF offered by BASF

    Find a price of Omega-3-Acid Ethyl Esters 90 bulk with DMF offered by BASF

    Find a price of Pantothenic Acid bulk with CEP offered by BASF

    Find a price of Polyethylene Glycol Monostearate bulk with DMF offered by BASF

    Find a price of Triclosan bulk with DMF offered by BASF

    Find a price of Vitamin A bulk with CEP offered by BASF

    Find a price of Vitamin D3 bulk with DMF offered by BASF

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    Find a price of 5-Ethenyl-Pyrrolidin-2-One bulk offered by BASF

    Find a price of Acitretin bulk offered by BASF

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    Find a price of Calcium Ascorbate bulk offered by BASF

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    Find a price of Hexanedioic Acid, Polymer With 1,6-Hexanediol bulk offered by BASF

    Find a price of Isotretinoin bulk offered by BASF

    Find a price of Macrogol bulk offered by BASF

    Find a price of Paracetamol bulk offered by BASF

    Find a price of Pyridoxine Hydrochloride bulk offered by BASF

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    Find a price of Sodium Ascorbate bulk offered by BASF

    Find a price of Thiamine Hydrochloride bulk offered by BASF

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    Find a price of N-[1-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL 2-NAPHTHALENYL) bulk offered by BASF

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    Find a price of MFG SITE FACILITIES OPERATING PROCEDURES AND PERSONEL FOR OSLO NORWAY bulk offered by BASF

    Find a price of STERILE AREA 1 DEPARTMENT AT MONZA FACILITY IN MILAN, ITALY. bulk offered by BASF

    Find a price of KOLLIDON 12 PF, POLYVINYLPYRROLIDONE bulk offered by BASF

    Find a price of UVINUL N539 SG bulk offered by BASF

    Find a price of RADIO-PHARMACEUTICAL SYNTHESIS MODULE << SYNTHERArV1 >> bulk offered by BASF

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    Find a price of Ibuprofen Lysinate bulk offered by BASF

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