Looking for 1491917-83-9 / Sacituzumab Govitecan API manufacturers, exporters & distributors?
Sacituzumab Govitecan manufacturers, exporters & distributors
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API | Excipient name
Sacituzumab Govitecan
Synonyms
Sacituzumab govitecan [usan], 1491917-83-9, Hrs7-sn38, Unii-m9byu8xdq6, Hrs 7sn38, Immu 132
Unique Ingredient Identifier (UNII)
DA64T2C2IO
About Sacituzumab Govitecan
Sacituzumab Govitecan is an antibody drug conjugate containing the humanized monoclonal antibody, hRS7, against tumor-associated calcium signal transducer 2 (TACSTD2 or TROP2) and linked to the active metabolite of irinotecan, 7-ethyl-10-hydroxycamptothecin (SN-38), with potential antineoplastic activity. The antibody moiety of sacituzumab govitecan selectively binds to TROP2. After internalization and proteolytic cleavage, SN-38 selectively stabilizes topoisomerase I-DNA covalent complexes, resulting in DNA breaks that inhibit DNA replication and trigger apoptosis. TROP2, also known as epithelial glycoprotein-1 (EGP-1), is a transmembrane calcium signal transducer that is overexpressed by a variety of human epithelial carcinomas; this antigen is involved in the regulation of cell-cell adhesion and its expression is associated with increased cancer growth, aggressiveness and metastasis.
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For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.