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01 4Bayer Inc.

02 1Gowling Lafleur Henderson LLP

03 9Gowling WLG (Canada) LLP

04 3Gowlings

05 2Ridout & Maybee LLP

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PharmaCompass

01

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ASPEN
Not Confirmed
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ASPEN
Not Confirmed

Interferon beta-1b

Brand Name : BETASERON

Patent Number : 1340861

Filing Date : 1983-10-12

Strength per Unit : 0.3mg per vial (250 ug / mL when reconstituted)

Dosage Form : Lyophilized powder with accompanying diluent

Human Or VET : Human

Route of Administration : Subcutanous injection

Patent Expiration Date : 2016-12-28

Date Granted : 1999-12-28

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02

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ASPEN
Not Confirmed
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Not Confirmed

Interferon beta-1b

Brand Name : BETASERON

Patent Number : 1339707

Filing Date : 1986-08-20

Strength per Unit : 0.3mg per vial (250 ug / mL when reconstituted)

Dosage Form : Lyophilized powder with accompanying diluent

Human Or VET : Human

Route of Administration : Subcutanous injection

Patent Expiration Date : 2015-03-10

Date Granted : 1998-03-10

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03

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ASPEN
Not Confirmed
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ASPEN
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Interferon beta-1b

Brand Name : FERONA

Patent Number : 1339707

Filing Date : 1986-08-20

Strength per Unit : 0.3 mg / vial (250 ?g / ml)

Dosage Form : Lyophilized powder with accompanying diluent

Human Or VET : Human

Route of Administration : Subcutaneous Injection

Patent Expiration Date : 2015-03-10

Date Granted : 1998-03-10

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04

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ASPEN
Not Confirmed
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ASPEN
Not Confirmed

Interferon beta-1b

Brand Name : FERONA

Patent Number : 1340861

Filing Date : 1983-10-12

Strength per Unit : 0.3 mg / vial (250 ?g / ml)

Dosage Form : Lyophilized powder with accompanying diluent

Human Or VET : Human

Route of Administration : Subcutaneous Injection

Patent Expiration Date : 2016-12-28

Date Granted : 1999-12-28

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05

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ASPEN
Not Confirmed
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ASPEN
Not Confirmed

Interferon beta-1a

Brand Name : AVONEX

Patent Number : 2275890

Filing Date : 1997-12-23

Strength per Unit : 30 mcg / 0.5mL

Dosage Form : solution

Human Or VET : Human

Route of Administration : Intramuscular

Patent Expiration Date : 2017-12-23

Date Granted : 2011-11-01

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06

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ASPEN
Not Confirmed
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ASPEN
Not Confirmed

Interferon beta-1a

Brand Name : AVONEX

Patent Number : 1341604

Filing Date : 1981-04-04

Strength per Unit : 30 mcg / 0.5mL

Dosage Form : solution

Human Or VET : Human

Route of Administration : Intramuscular

Patent Expiration Date : 2027-05-04

Date Granted : 2010-05-04

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07

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ASPEN
Not Confirmed
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ASPEN
Not Confirmed

Interferon beta-1a

Brand Name : AVONEX

Patent Number : 1341604

Filing Date : 1981-04-04

Strength per Unit : 30 mcg / mL

Dosage Form : Lyophilized powder for resonstitution

Human Or VET : Human

Route of Administration : Intramuscular injection

Patent Expiration Date : 2027-05-04

Date Granted : 2010-05-04

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08

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Not Confirmed
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PEGINTERFERON BETA-1A

Brand Name : PLEGRIDY

Patent Number : 2345138

Filing Date : 1999-10-15

Strength per Unit : 125 ?g / 0.5mL

Dosage Form : LIQUID

Human Or VET : Human

Route of Administration : SUBCUTANEOUS

Patent Expiration Date : 2019-10-15

Date Granted : 2009-12-15

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09

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ASPEN
Not Confirmed
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Not Confirmed

PEGINTERFERON BETA-1A

Brand Name : PLEGRIDY

Patent Number : 2473526

Filing Date : 2003-01-17

Strength per Unit : 125 ?g / 0.5mL

Dosage Form : LIQUID

Human Or VET : Human

Route of Administration : SUBCUTANEOUS

Patent Expiration Date : 2023-01-17

Date Granted : 2013-10-22

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10

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ASPEN
Not Confirmed

Gowlings

Canada
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ASPEN
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Interferon beta-1b

Brand Name : EXTAVIA

Patent Number : 1340861

Filing Date : 1983-10-12

Strength per Unit : 0.3 mg / vial

Dosage Form : Powder for Solution

Human Or VET : Human

Route of Administration : Subcutaneous

Patent Expiration Date : 2016-12-28

Date Granted : 1999-12-28

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