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    Chemistry

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    Also known as: Sevelamer hcl, 152751-57-0, 2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride, 182683-00-7, Chebi:32127, Bcp21176
    Molecular Formula
    C6H13Cl2NO
    Molecular Weight
    186.08  g/mol
    InChI Key
    KHNXRSIBRKBJDI-UHFFFAOYSA-N
    Sevelamer Hydrochloride
    A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.
    1 2D Structure

    Sevelamer Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C3H5ClO.C3H7N.ClH/c4-1-3-2-5-3;1-2-3-4;/h3H,1-2H2;2H,1,3-4H2;1H
    2.1.3 InChI Key
    KHNXRSIBRKBJDI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C=CCN.C1C(O1)CCl.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Carbonate, Sevelamer

    2. Gt335 012

    3. Gt335-012

    4. Gt335012

    5. Hydrochloride, Sevelamer

    6. Renagel

    7. Sevelamer

    8. Sevelamer Carbonate

    2.2.2 Depositor-Supplied Synonyms

    1. Sevelamer Hcl

    2. 152751-57-0

    3. 2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride

    4. 182683-00-7

    5. Chebi:32127

    6. Bcp21176

    7. Cga75157

    8. Sevelamer Hydrochloride (jan/usan)

    9. S4129

    10. Akos025149504

    11. Ac-2089

    12. Hs-0082

    13. Db-063954

    14. Ft-0653684

    15. D01983

    16. Ab01568265_01

    17. 2-propen-1-amine Hydrochloride Polymer With (chloromethyl)oxirane

    2.3 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 186.08 g/mol
    Molecular Formula C6H13Cl2NO
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass185.0374194 g/mol
    Monoisotopic Mass185.0374194 g/mol
    Topological Polar Surface Area38.6 Ų
    Heavy Atom Count10
    Formal Charge0
    Complexity55.1
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Indication

    Tasermity is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis. Sevelamer hydrochloride should be used within the context of a multiple therapeutic approach, which could include calcium supplements, 1,25 dihydroxy Vitamin D3 or one of its analogues to control the development of renal bone disease.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Chelating Agents

    Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Phosphate Chelating Activity [MoA]; Phosphate Binder [EPC]
    5.3 ATC Code

    V03AE02

    API Reference Price

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    03-Jan-2022
    16-Feb-2026
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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - 400MG

    USFDA APPLICATION NUMBER - 21179

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    DOSAGE - TABLET;ORAL - 800MG

    USFDA APPLICATION NUMBER - 21179

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    ABOUT THIS PAGE

    Looking for 152751-57-0 / Sevelamer Hydrochloride API manufacturers, exporters & distributors?

    Sevelamer Hydrochloride manufacturers, exporters & distributors 1

    54

    PharmaCompass offers a list of Sevelamer Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sevelamer Hydrochloride manufacturer or Sevelamer Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sevelamer Hydrochloride manufacturer or Sevelamer Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Sevelamer Hydrochloride API Price utilized in the formulation of products. Sevelamer Hydrochloride API Price is not always fixed or binding as the Sevelamer Hydrochloride Price is obtained through a variety of data sources. The Sevelamer Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Sevelamer Hydrochloride

    Synonyms

    Sevelamer hcl, 152751-57-0, 2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride, 182683-00-7, Chebi:32127, Bcp21176

    Cas Number

    152751-57-0

    About Sevelamer Hydrochloride

    A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.

    Allylamine hydrochloride - epichlorhydrin copolymer Manufacturers

    A Allylamine hydrochloride - epichlorhydrin copolymer manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Allylamine hydrochloride - epichlorhydrin copolymer, including repackagers and relabelers. The FDA regulates Allylamine hydrochloride - epichlorhydrin copolymer manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Allylamine hydrochloride - epichlorhydrin copolymer API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Allylamine hydrochloride - epichlorhydrin copolymer manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Allylamine hydrochloride - epichlorhydrin copolymer Suppliers

    A Allylamine hydrochloride - epichlorhydrin copolymer supplier is an individual or a company that provides Allylamine hydrochloride - epichlorhydrin copolymer active pharmaceutical ingredient (API) or Allylamine hydrochloride - epichlorhydrin copolymer finished formulations upon request. The Allylamine hydrochloride - epichlorhydrin copolymer suppliers may include Allylamine hydrochloride - epichlorhydrin copolymer API manufacturers, exporters, distributors and traders.

    click here to find a list of Allylamine hydrochloride - epichlorhydrin copolymer suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Allylamine hydrochloride - epichlorhydrin copolymer USDMF

    A Allylamine hydrochloride - epichlorhydrin copolymer DMF (Drug Master File) is a document detailing the whole manufacturing process of Allylamine hydrochloride - epichlorhydrin copolymer active pharmaceutical ingredient (API) in detail. Different forms of Allylamine hydrochloride - epichlorhydrin copolymer DMFs exist exist since differing nations have different regulations, such as Allylamine hydrochloride - epichlorhydrin copolymer USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Allylamine hydrochloride - epichlorhydrin copolymer DMF submitted to regulatory agencies in the US is known as a USDMF. Allylamine hydrochloride - epichlorhydrin copolymer USDMF includes data on Allylamine hydrochloride - epichlorhydrin copolymer's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Allylamine hydrochloride - epichlorhydrin copolymer USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Allylamine hydrochloride - epichlorhydrin copolymer suppliers with USDMF on PharmaCompass.

    Allylamine hydrochloride - epichlorhydrin copolymer JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Allylamine hydrochloride - epichlorhydrin copolymer Drug Master File in Japan (Allylamine hydrochloride - epichlorhydrin copolymer JDMF) empowers Allylamine hydrochloride - epichlorhydrin copolymer API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Allylamine hydrochloride - epichlorhydrin copolymer JDMF during the approval evaluation for pharmaceutical products. At the time of Allylamine hydrochloride - epichlorhydrin copolymer JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Allylamine hydrochloride - epichlorhydrin copolymer suppliers with JDMF on PharmaCompass.

    Allylamine hydrochloride - epichlorhydrin copolymer WC

    A Allylamine hydrochloride - epichlorhydrin copolymer written confirmation (Allylamine hydrochloride - epichlorhydrin copolymer WC) is an official document issued by a regulatory agency to a Allylamine hydrochloride - epichlorhydrin copolymer manufacturer, verifying that the manufacturing facility of a Allylamine hydrochloride - epichlorhydrin copolymer active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Allylamine hydrochloride - epichlorhydrin copolymer APIs or Allylamine hydrochloride - epichlorhydrin copolymer finished pharmaceutical products to another nation, regulatory agencies frequently require a Allylamine hydrochloride - epichlorhydrin copolymer WC (written confirmation) as part of the regulatory process.

    click here to find a list of Allylamine hydrochloride - epichlorhydrin copolymer suppliers with Written Confirmation (WC) on PharmaCompass.

    Allylamine hydrochloride - epichlorhydrin copolymer NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Allylamine hydrochloride - epichlorhydrin copolymer as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Allylamine hydrochloride - epichlorhydrin copolymer API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Allylamine hydrochloride - epichlorhydrin copolymer as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Allylamine hydrochloride - epichlorhydrin copolymer and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Allylamine hydrochloride - epichlorhydrin copolymer NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Allylamine hydrochloride - epichlorhydrin copolymer suppliers with NDC on PharmaCompass.

    Allylamine hydrochloride - epichlorhydrin copolymer GMP

    Allylamine hydrochloride - epichlorhydrin copolymer Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Allylamine hydrochloride - epichlorhydrin copolymer GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Allylamine hydrochloride - epichlorhydrin copolymer GMP manufacturer or Allylamine hydrochloride - epichlorhydrin copolymer GMP API supplier for your needs.

    Allylamine hydrochloride - epichlorhydrin copolymer CoA

    A Allylamine hydrochloride - epichlorhydrin copolymer CoA (Certificate of Analysis) is a formal document that attests to Allylamine hydrochloride - epichlorhydrin copolymer's compliance with Allylamine hydrochloride - epichlorhydrin copolymer specifications and serves as a tool for batch-level quality control.

    Allylamine hydrochloride - epichlorhydrin copolymer CoA mostly includes findings from lab analyses of a specific batch. For each Allylamine hydrochloride - epichlorhydrin copolymer CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Allylamine hydrochloride - epichlorhydrin copolymer may be tested according to a variety of international standards, such as European Pharmacopoeia (Allylamine hydrochloride - epichlorhydrin copolymer EP), Allylamine hydrochloride - epichlorhydrin copolymer JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Allylamine hydrochloride - epichlorhydrin copolymer USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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