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    Technical details about Zoledronate Disodium, learn more about the structure, uses, toxicity, action, side effects and more

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    Zoledronate Disodium

    APIs // Active Pharmaceutical Ingredients

    PharmaCompass

    Boai NKY Pharmaceuticals Ltd. is one of the largest global PVP suppliers.

    Renejix: CDMO with expertise in small molecule oral dosage, delivery tech, and multi-modality manufacturing.

    2D Structure
    1. Also known as: Zoledronic acid disodium, Zoledronate disodium anhydrous, 165800-07-7, 5csv5k1879, 131654-46-1, Unii-5csv5k1879
    Molecular Formula
    C5H8N2Na2O7P2
    Molecular Weight
    316.05  g/mol
    InChI Key
    OPQQEYHAVUNQNA-UHFFFAOYSA-L
    FDA UNII
    5CSV5K1879
    Zoledronate Disodium is the disodium salt form of zoledronate, a synthetic imidazole, third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]-2-imidazol-1-ylethyl]phosphinate
    2.1.2 InChI
    InChI=1S/C5H10N2O7P2.2Na/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);;/q;2*+1/p-2
    2.1.3 InChI Key
    OPQQEYHAVUNQNA-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    C1=CN(C=N1)CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    5CSV5K1879
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. Zoledronic Acid Disodium

    2. Zoledronate Disodium Anhydrous

    3. 165800-07-7

    4. 5csv5k1879

    5. 131654-46-1

    6. Unii-5csv5k1879

    7. Dtxsid80157167

    8. Akos015969312

    9. J-010228

    10. Q27261841

    11. Phosphonic Acid, (1-hydroxy-2-(1h-imidazol-1-yl)ethylidene)bis-, Disodium Salt

    12. Phosphonic Acid, P,p'-(1-hydroxy-2-(1h-imidazol-1-yl)ethylidene)bis-, Sodium Salt (1:2)

    2.4 Create Date
    2006-03-21
    3 Chemical and Physical Properties
    Molecular Weight 316.05 g/mol
    Molecular Formula C5H8N2Na2O7P2
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count4
    Exact Mass315.96021316 g/mol
    Monoisotopic Mass315.96021316 g/mol
    Topological Polar Surface Area159 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity322
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
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