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    Technical details about Zinc Stearate, learn more about the structure, uses, toxicity, action, side effects and more

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    Zinc Stearate

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    ANALYTICAL SOLUTION(s)

    DIGITAL CONTENT

    PharmaCompass

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    2D Structure
    Also known as: 557-05-1, Zinc distearate, Zinc octadecanoate, Octadecanoic acid, zinc salt, Metallac, Stearates
    Molecular Formula
    C36H70O4Zn
    Molecular Weight
    632.3  g/mol
    InChI Key
    XOOUIPVCVHRTMJ-UHFFFAOYSA-L
    FDA UNII
    H92E6QA4FV
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    zinc;octadecanoate
    2.1.2 InChI
    InChI=1S/2C18H36O2.Zn/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
    2.1.3 InChI Key
    XOOUIPVCVHRTMJ-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Zn+2]
    2.2 Other Identifiers
    2.2.1 UNII
    H92E6QA4FV
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aluminum Monostearate

    2. Aluminum Tristearate

    3. Ammonium Stearate

    4. Calcium Stearate

    5. Magnesium Stearate

    6. Octadecanoic Acid

    7. Sodium Stearate

    8. Stearic Acid

    2.3.2 Depositor-Supplied Synonyms

    1. 557-05-1

    2. Zinc Distearate

    3. Zinc Octadecanoate

    4. Octadecanoic Acid, Zinc Salt

    5. Metallac

    6. Stearates

    7. Zn Stearate

    8. Talculin Z

    9. Stavinor Zn-e

    10. Zinc Bisstearate

    11. Metasap 576

    12. Zinc Stearate W. S

    13. Stearic Acid, Zinc Salt

    14. Zinc Stearate [usp]

    15. Stearic Acid Zinc Salt

    16. H92e6qa4fv

    17. Zinc Stearate (usp)

    18. Hydense

    19. Hytech

    20. Mathe

    21. Coad

    22. Zinci Stearas

    23. Zink Distearat

    24. Unichem Zs

    25. Zincum Stearinicum

    26. 144188-98-7

    27. Dibasic Zinc Stearate

    28. Petrac Zn-41

    29. Caswell No. 926

    30. Synpro Stearate (van)

    31. Witco Zinc Stearate Usp

    32. Hsdb 212

    33. Nsc-25957

    34. Zinc Distearate, Pure

    35. Einecs 209-151-9

    36. Nsc 25957

    37. Zinc Stearate, Total Dust

    38. Unii-h92e6qa4fv

    39. Epa Pesticide Chemical Code 077002

    40. Zincstearate

    41. Ai3-00388

    42. Znst

    43. Zinc;octadecanoate

    44. Zinc Stearate, Respirable Fraction

    45. Zinc Dioctadecanoate

    46. Zinc(ii) Stearate

    47. Zinc Stearate Spl

    48. Zinc Stearate Tcg

    49. Zinc Stearate Tcp

    50. Einecs 257-363-5

    51. Octadecanoic Acid, Zinc Salt, Basic

    52. Octadecanoic Acid, Zinc Salt (2:1)

    53. Lubimax Zinc Stearate

    54. Rashayan Zinc Stearate

    55. Starbld0000624

    56. Ec 209-151-9

    57. Schembl4923

    58. Zinc Stearate [ii]

    59. Zinc Stearate [mi]

    60. Zinc Stearate [hsdb]

    61. Zinc Stearate [inci]

    62. Zinc Stearate [vandf]

    63. Zinc Stearate [mart.]

    64. Zinc Stearate [usp-rs]

    65. Zinc Stearate [who-dd]

    66. Dtxsid7027209

    67. Zinc Stearate, Zno 12.5-14%

    68. Mfcd00013031

    69. Zinc Stearate [ep Monograph]

    70. Zinc Stearate [usp Monograph]

    71. Akos015915230

    72. 51731-04-5

    73. Ft-0645152

    74. D06370

    75. A830766

    76. Q204923

    2.4 Create Date
    2005-07-19
    3 Chemical and Physical Properties
    Molecular Weight 632.3 g/mol
    Molecular Formula C36H70O4Zn
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count30
    Exact Mass630.456552 g/mol
    Monoisotopic Mass630.456552 g/mol
    Topological Polar Surface Area80.3 Ų
    Heavy Atom Count41
    Formal Charge0
    Complexity196
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Zinc stearate is a mild antiseptic and astringent, and it has been used as a local soothing application for inflammatory and irritating skin diseases.

    Cosmetic Ingredient Expert Review Panel; Final Report on the Safety Assessment of Lithium Stearate, Aluminum Distearate, Aluminum Stearate, Aluminum Tristearate, Ammonium Stearate, Calcium Stearate, Magnesium Stearate, Potassium Stearate, Sodium Stearate and Zinc Stearate. Journal of the American College of Toxicology 1 (2): 143-77 (1982).

    Zinc stearate is primarily used in pharmacuetical formulations as a lubricant in tablet and capsule manufacture at concentrations up to 1.5% w/w.

    Rowe, R.C., Sheskey, P.J., Quinn, M.E.; (Eds.), Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press, London, England 2009, p. 793

    In dental cement

    Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. 7: 467 (1979)

    4.2 Drug Warning

    ... Its use as dusting powder for infants is not recommended.

    American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 84:24

    5 Pharmacology and Biochemistry
    5.1 Absorption, Distribution and Excretion

    In humans with no excessive intake of zinc, the body burden half-time of absorbed radio-labelled zinc has been observed to range from 162 to 500 days. After parenteral administration of 65Zn2+, half-times ranged from 100 to 500 days. /Zinc ions/

    European Chemicals Bureau; Risk Assessment Report on Zinc Distearate, CAS-No.: 557-05-1, 91051-01-3. EINECS-No.: 209-151-9, 293-049-4. Part II - Human Health p.37 (2004). Available from, as of March 24, 2011: https://ecb.jrc.ec.europa.eu/DOCUMENTS/Existing-Chemicals/RISK_ASSESSMENT/REPORT/zincdistearatereport074.pdf

    Within certain limits, mammals can maintain the total body zinc and the physiologically required levels of zinc in the various tissues constant, both at low and high dietary zinc intakes. The sites of regulation of zinc metabolism are: absorption of Zn2+ from the gastrointestinal tract, excretion of zinc in urine, exchange of zinc with erythrocytes, release of zinc from tissue, and secretion of zinc into the gastrointestinal tract. Regulation of gastrointestinal absorption and gastrointestinal secretion probably contributes the most to zinc homeostasis. /Zinc ions/

    European Chemicals Bureau; Risk Assessment Report on Zinc Distearate, CAS-No.: 557-05-1, 91051-01-3. EINECS-No.: 209-151-9, 293-049-4. Part II - Human Health p.38 (2004). Available from, as of March 24, 2011: https://ecb.jrc.ec.europa.eu/DOCUMENTS/Existing-Chemicals/RISK_ASSESSMENT/REPORT/zincdistearatereport074.pdf

    5.2 Metabolism/Metabolites

    Zinc is mostly bound to organic ligands rather than free in solution as a cation. Zinc is found in diffusible and non-diffusible forms in the blood and about 66% of the diffusible form of zinc in the plasma is freely exchangeable and loosely bound to albumin. A small amount of the non-diffusible form of zinc is tightly bound to 2-macroglobulin in the plasma and is not freely exchangeable with other zinc ligands. Zinc is incorporated into and dissociated from alpha2-macroglobulin only in the liver. /Zinc ions/

    European Chemicals Bureau; Risk Assessment Report on Zinc Distearate, CAS-No.: 557-05-1, 91051-01-3. EINECS-No.: 209-151-9, 293-049-4. Part II - Human Health p.36 (2004). Available from, as of March 24, 2011: https://ecb.jrc.ec.europa.eu/DOCUMENTS/Existing-Chemicals/RISK_ASSESSMENT/REPORT/zincdistearatereport074.pdf

    5.3 Biological Half-Life

    For zinc, whole body: 162-500 days; [TDR, p. 1245]

    TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 1245

    In humans with no excessive intake of zinc, the body burden half-time of absorbed radio-labelled zinc has been observed to range from 162 to 500 days. After parenteral administration of 65Zn2+, half-times ranged from 100 to 500 days. /Zinc ions/

    European Chemicals Bureau; Risk Assessment Report on Zinc Distearate, CAS-No.: 557-05-1, 91051-01-3. EINECS-No.: 209-151-9, 293-049-4. Part II - Human Health p.37 (2004). Available from, as of March 24, 2011: https://ecb.jrc.ec.europa.eu/DOCUMENTS/Existing-Chemicals/RISK_ASSESSMENT/REPORT/zincdistearatereport074.pdf

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