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    Technical details about Zinc(II) Gluconate, learn more about the structure, uses, toxicity, action, side effects and more

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    Zinc(II) Gluconate

    DOSSIERs // Finished Dosage Forms

    PharmaCompass

    Boai NKY Pharmaceuticals Ltd. is one of the largest global PVP suppliers.

    Renejix: CDMO with expertise in small molecule oral dosage, delivery tech, and multi-modality manufacturing.

    2D Structure
    1. Also known as: 4468-02-4, Zincgluconate, Zincum gluconicum, Gluconic acid zinc complex, Zinc d-gluconate (1:2), Bis(d-gluconato-o1,o2) zinc
    Molecular Formula
    C12H22O14Zn
    Molecular Weight
    455.7  g/mol
    InChI Key
    WHMDKBIGKVEYHS-IYEMJOQQSA-L
    FDA UNII
    U6WSN5SQ1Z
    Zinc Gluconate is a nutritional supplement containing the zinc salt form of gluconic acid for the purpose of providing zinc. As an essential trace element, zinc is of key importance in many biological processes, acts as an antioxidant and strengthens the immune system. Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    zinc;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
    2.1.2 InChI
    InChI=1S/2C6H12O7.Zn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
    2.1.3 InChI Key
    WHMDKBIGKVEYHS-IYEMJOQQSA-L
    2.1.4 Canonical SMILES
    C(C(C(C(C(C(=O)[O-])O)O)O)O)O.C(C(C(C(C(C(=O)[O-])O)O)O)O)O.[Zn+2]
    2.1.5 Isomeric SMILES
    C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Zn+2]
    2.2 Other Identifiers
    2.2.1 UNII
    U6WSN5SQ1Z
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Boron Gluconate

    2. D-gluconate

    3. D-gluconic Acid

    4. Dextronic Acid

    5. Gluconate

    6. Gluconic Acid

    7. Gluconic Acid, (113)indium-labeled

    8. Gluconic Acid, (14)c-labeled

    9. Gluconic Acid, (159)dysprosium-labeled Salt

    10. Gluconic Acid, (99)technecium (5+) Salt

    11. Gluconic Acid, 1-(14)c-labeled

    12. Gluconic Acid, 6-(14)c-labeled

    13. Gluconic Acid, Aluminum (3:1) Salt

    14. Gluconic Acid, Ammonium Salt

    15. Gluconic Acid, Calcium Salt

    16. Gluconic Acid, Cesium(+3) Salt

    17. Gluconic Acid, Cobalt (2:1) Salt

    18. Gluconic Acid, Copper Salt

    19. Gluconic Acid, Fe(+2) Salt, Dihydrate

    20. Gluconic Acid, Lanthanum(+3) Salt

    21. Gluconic Acid, Magnesium (2:1) Salt

    22. Gluconic Acid, Manganese (2:1) Salt

    23. Gluconic Acid, Monolithium Salt

    24. Gluconic Acid, Monopotassium Salt

    25. Gluconic Acid, Monosodium Salt

    26. Gluconic Acid, Potassium Salt

    27. Gluconic Acid, Sodium Salt

    28. Gluconic Acid, Strontium (2:1) Salt

    29. Gluconic Acid, Tin(+2) Salt

    30. Gluconic Acid, Zinc Salt

    31. Lithium Gluconate

    32. Magnerot

    33. Magnesium Gluconate

    34. Maltonic Acid

    35. Manganese Gluconate

    36. Pentahydroxycaproic Acid

    37. Sodium Gluconate

    2.3.2 Depositor-Supplied Synonyms

    1. 4468-02-4

    2. Zincgluconate

    3. Zincum Gluconicum

    4. Gluconic Acid Zinc Complex

    5. Zinc D-gluconate (1:2)

    6. Bis(d-gluconato-o1,o2) Zinc

    7. Gluconic Acid Zinc(ii) Salt

    8. Zinc Gluconate (usp)

    9. U6wsn5sq1z

    10. Zinc, Bis(d-gluconato-kappao1,kappao2)-, (t-4)-

    11. Gluconic Acid Zinc

    12. Zinc(ii) Gluconate

    13. Schembl21280

    14. Zinc Gluconate [fcc]

    15. Zinc Gluconate [hsdb]

    16. Zinc Gluconate [inci]

    17. Zinc Gluconate [vandf]

    18. Zinc Gluconate [mart.]

    19. Chembl3833377

    20. Zinc Gluconate [who-dd]

    21. Zincum Gluconicum [hpus]

    22. Chebi:29708

    23. Dtxsid20894125

    24. Zinc Gluconate [green Book]

    25. Zinc Gluconate [ep Impurity]

    26. Zinc Gluconate [ep Monograph]

    27. Akos015951235

    28. Zinc Gluconate [usp Monograph]

    29. Db11248

    30. Gluconic Acid Zinc Complex [mi]

    31. G0277

    32. D02390

    33. F71322

    34. A826659

    35. Q-201160

    36. Q3822815

    37. Zinc(ii) (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate

    38. Zinc (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;zinc Gluconate Hydrate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 455.7 g/mol
    Molecular Formula C12H22O14Zn
    Hydrogen Bond Donor Count10
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count8
    Exact Mass454.030097 g/mol
    Monoisotopic Mass454.030097 g/mol
    Topological Polar Surface Area283 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity165
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    MEDICATION (VET): CATTLE DERMATOMYCOSIS, CAUSED BY TRICHOPHYTON VERRUCOSUM (TRICHOPHYTOSIS) WAS TREATED BY ORAL ADMIN OF PREPN CONTAINING 20-70% ZINC GLUCONATE, 2-10% SULFUR, 0.2-1% VITAMIN A (106 IU), 2-6% METHIONINE, & INERT CARRIER SUCH AS CALCIUM CARBONATE OR FLOUR.

    KOVAC L; CZECH PATENT 184924 09/15/78

    DIETARY SUPPLEMENT & FOOD ADDITIVE; VITAMIN TABLETS

    Sax, N.I. and R.J. Lewis, Sr. (eds.). Hawley's Condensed Chemical Dictionary. 11th ed. New York: Van Nostrand Reinhold Co., 1987., p. 1253

    EXPTL USE: ZINC GLUCONATE ADDED TO SUBOPTIMAL DOSES OF ORTHO-GYNOL JELLY OR DELFEN CREAM IMPROVES VAGINAL CONTRACEPTIVE EFFICACY OF THESE PRODUCTS.

    PMID:7214913 WILLIAMS WL; CONTRACEPTION 22 (6): 659-72 (1980)

    EXPTL USE: TOXIC BLOOD LEAD LEVELS IN WORKERS DECR FROM 61.6 TO 46.0 UG/100 ML AFTER 24 WK TREATMENT WITH VITAMIN C & ZINC (2 G & 60 MG, DAILY). HEMOGLOBIN LEVELS INCR SIGNIFICANTLY & SERUM & WHOLE BLOOD COPPER LEVELS DECREASED FOLLOWING TREATMENT.

    PAPAIOANNOU R ET AL; J ORTHOMOL PSYCHIATRY 7 (2): 94-106 (1978)

    For more Therapeutic Uses (Complete) data for ZINC GLUCONATE (8 total), please visit the HSDB record page.

    4.2 Drug Warning

    A potential role for zinc in retarding the progression of age-related macular degeneration has not been proven. Zinc salts have not been found to be beneficial in the treatment of acute intermittent porphyria. /Zinc supplements/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 3020

    Zinc injection that contains benzyl alcohol as a preservative should not be used in newborn and immature infants. The use of benzyl alcohol in neonates has been associated with a fatal toxic syndrome consisting of metabolic acidosis and CNS, respiratory, circulatory, and renal function impairment. /Zinc supplements/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 3020

    4.3 Drug Indication

    Zinc gluconate is mainly indicated in conditions like zinc deficiency, and can also be administered in adjunctive therapy as an alternative drug of choice in diarrhea.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Zinc is an important mineral found in almost every cell in the human body. It promotes the activity of about 100 enzymes. Zinc deficiency is often associated with an increased risk of infection. When they are used to treat the common cold, zinc supplements may interfere with rhinovirus cleavage or adhesion and may play a role in protecting plasma membranes from microbial toxins and complement.

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Decreased Copper Ion Absorption [PE]; Copper Absorption Inhibitor [EPC]
    5.3 ATC Code

    A - Alimentary tract and metabolism

    A12 - Mineral supplements

    A12C - Other mineral supplements

    A12CB - Zinc

    A12CB02 - Zinc gluconate

    5.4 Absorption, Distribution and Excretion

    Absorption

    Please refer to DrugBank entry [DB01593]

    Route of Elimination

    Feces and urine

    Volume of Distribution

    Stored primarily in skeletal muscle and bone.

    Clearance

    Please refer to DrugBank entry [DB01593]

    5.5 Metabolism/Metabolites

    Please refer to DrugBank entry [DB01593]

    5.6 Biological Half-Life

    280 days

    5.7 Mechanism of Action

    Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV).

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