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    Technical details about Vincristine Sulfate, learn more about the structure, uses, toxicity, action, side effects and more

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    Vincristine Sulfate

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    2D Structure
    1. Also known as: 2068-78-2, Kyocristine, Vincristine sulphate, Vincrisul, Leurocristine sulfate, Oncovin
    Molecular Formula
    C46H58N4O14S
    Molecular Weight
    923.0  g/mol
    InChI Key
    AQTQHPDCURKLKT-JKDPCDLQSA-N
    An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid
    2.1.2 InChI
    InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
    2.1.3 InChI Key
    AQTQHPDCURKLKT-JKDPCDLQSA-N
    2.1.4 Canonical SMILES
    CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
    2.1.5 Isomeric SMILES
    CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Cellcristin

    2. Citomid

    3. Farmistin

    4. Leurocristine

    5. Oncovin

    6. Oncovine

    7. Onkocristin

    8. Pfs, Vincasar

    9. Sulfate, Vincristine

    10. Vincasar

    11. Vincasar Pfs

    12. Vincristin Bristol

    13. Vincristin Medac

    14. Vincristine

    15. Vincrisul

    16. Vintec

    2.2.2 Depositor-Supplied Synonyms

    1. 2068-78-2

    2. Kyocristine

    3. Vincristine Sulphate

    4. Vincrisul

    5. Leurocristine Sulfate

    6. Oncovin

    7. Onkovin

    8. Marqibo

    9. 22-oxovincaleukoblastine Sulfate

    10. Vcr Sulfate

    11. Rel-vincristine Sulfate

    12. Nsc 67574

    13. Lilly 37231

    14. Nsc67574

    15. Nsc-67574

    16. Leurocristine, Sulfate (1:1) (salt)

    17. Alkaloid Extracted From Vinca Rosea Linn

    18. Novopharm

    19. Chebi:79401

    20. 1217704-93-2

    21. Mls002702994

    22. Lilly-37231

    23. Vincristini Sulfas

    24. Oncovin (lilly)

    25. Vincasar (tn)

    26. Marqibo (tn)

    27. Oncovin (tn)

    28. Vincrex (tn)

    29. Vincristine, Sulfate

    30. Leurocristine, Sulfate

    31. Vincristine Sulphate Salt

    32. Vincristine Sulfate Liposome

    33. Schembl3710

    34. Leurocristine Sulfate (1:1)

    35. Chembl501867

    36. Dtxsid8044331

    37. Vincristine Sulfate (jp17/usp)

    38. Hms3414l13

    39. Hms3678l11

    40. Mfcd08706469

    41. Akos015895862

    42. V0129

    43. Lcr

    44. Vcr

    45. D02197

    46. 068v782

    47. A936684

    48. Methyl (3ar,3a1r,4r,5s,5ar,10br)-4-acetoxy-3a-ethyl-9-((3s,5s,7s,9s)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2h-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1h-indolizino[8,1-cd]carbazole-5-carboxylate Sulfate

    2.3 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 923.0 g/mol
    Molecular Formula C46H58N4O14S
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count16
    Rotatable Bond Count10
    Exact Mass922.36702371 g/mol
    Monoisotopic Mass922.36702371 g/mol
    Topological Polar Surface Area254 Ų
    Heavy Atom Count65
    Formal Charge0
    Complexity1830
    Isotope Atom Count0
    Defined Atom Stereocenter Count9
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameMarqibo kit
    Active IngredientVincristine sulfate
    Dosage FormInjectable, liposomal
    RouteIntravenous
    Strength5mg/5ml (1mg/ml)
    Market StatusPrescription
    CompanyTalon Therap

    2 of 4  
    Drug NameVincristine sulfate pfs
    Active IngredientVincristine sulfate
    Dosage FormInjectable
    RouteInjection
    Strength1mg/ml
    Market StatusPrescription
    CompanyHospira; Teva Pharms Usa

    3 of 4  
    Drug NameMarqibo kit
    Active IngredientVincristine sulfate
    Dosage FormInjectable, liposomal
    RouteIntravenous
    Strength5mg/5ml (1mg/ml)
    Market StatusPrescription
    CompanyTalon Therap

    4 of 4  
    Drug NameVincristine sulfate pfs
    Active IngredientVincristine sulfate
    Dosage FormInjectable
    RouteInjection
    Strength1mg/ml
    Market StatusPrescription
    CompanyHospira; Teva Pharms Usa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antineoplastic Agents, Phytogenic

    Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)

    Tubulin Modulators

    Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Vinca Alkaloids [CS]; Vinca Alkaloid [EPC]
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