loader
Please Wait
Applying Filters...

Suanfarma Suanfarma

X
menu

    Market Place

    Market Place

    Post Enquiry

    Post Enquiry
    menu

    Technical details about Venglustat, learn more about the structure, uses, toxicity, action, side effects and more

    Client Email Product
    Menu

    Venglustat

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass

    Inke S.A: APIs manufacturing plant.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    1. Also known as: Ibiglustat, 1401090-53-6, Genz-682452, Sar402671, Gz/sar402671, Genz-682452-aa
    Molecular Formula
    C20H24FN3O2S
    Molecular Weight
    389.5  g/mol
    InChI Key
    YFHRCLAKZBDRHN-MRXNPFEDSA-N
    FDA UNII
    BLP1XA3FZA
    Venglustat is under investigation in clinical trial NCT01674036 (Safety, Tolerability and Pharmacokinetics of Genz-682452 in Healthy Men).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(3S)-1-azabicyclo[2.2.2]octan-3-yl] N-[2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl]carbamate
    2.1.2 InChI
    InChI=1S/C20H24FN3O2S/c1-20(2,17-12-27-18(22-17)14-3-5-15(21)6-4-14)23-19(25)26-16-11-24-9-7-13(16)8-10-24/h3-6,12-13,16H,7-11H2,1-2H3,(H,23,25)/t16-/m1/s1
    2.1.3 InChI Key
    YFHRCLAKZBDRHN-MRXNPFEDSA-N
    2.1.4 Canonical SMILES
    CC(C)(C1=CSC(=N1)C2=CC=C(C=C2)F)NC(=O)OC3CN4CCC3CC4
    2.1.5 Isomeric SMILES
    CC(C)(C1=CSC(=N1)C2=CC=C(C=C2)F)NC(=O)O[C@@H]3CN4CCC3CC4
    2.2 Other Identifiers
    2.2.1 UNII
    BLP1XA3FZA
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Genz-682452

    2. Gz-sar402671

    3. Ibiglustat

    2.3.2 Depositor-Supplied Synonyms

    1. Ibiglustat

    2. 1401090-53-6

    3. Genz-682452

    4. Sar402671

    5. Gz/sar402671

    6. Genz-682452-aa

    7. Venglustat [usan]

    8. Gz402671

    9. Blp1xa3fza

    10. (s)-quinuclidin-3-yl (2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamate

    11. Sar-402671

    12. [(3s)-1-azabicyclo[2.2.2]octan-3-yl] N-[2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl]carbamate

    13. Gz-402671

    14. (3s)-1-azabicyclo(2.2.2)octan-3-yl N-(2-(2-(4-fluorophenyl)-1,3-thiazol-4-yl)propan-2-yl)carbamate

    15. Carbamic Acid, N-(1-(2-(4-fluorophenyl)-4-thiazolyl)-1-methylethyl)-, (3s)-1-azabicyclo(2.2.2)oct-3-yl Ester

    16. Carbamic Acid, N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]-, (3s)-1-azabicyclo[2.2.2]oct-3-yl Ester

    17. Ibiglustat [inn]

    18. Unii-blp1xa3fza

    19. Venglustat [inn]

    20. Venglustat (usan/inn)

    21. Ibiglustat(genz-682452

    22. Venglustat [who-dd]

    23. Chembl4297611

    24. Schembl12615329

    25. Gtpl11550

    26. Gz/sar-402671

    27. Amy19519

    28. Bgc09053

    29. Ex-a1870

    30. Mfcd28502073

    31. Who 10063

    32. Akos027337125

    33. Zinc202143443

    34. Cs-6512

    35. Db14966

    36. Ac-35551

    37. As-52367

    38. Hy-16743

    39. D11633

    40. P14969

    41. Q27274745

    42. (s)-quinuclidin-3-yl 2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-ylcarbamate

    43. (s)-quinuclidin-3-yl(2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamate

    2.4 Create Date
    2012-10-08
    3 Chemical and Physical Properties
    Molecular Weight 389.5 g/mol
    Molecular Formula C20H24FN3O2S
    XLogP33.5
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count5
    Exact Mass389.15732635 g/mol
    Monoisotopic Mass389.15732635 g/mol
    Topological Polar Surface Area82.7 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity533
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of polycystic kidney disease

    Treatment of Parkinson's disease

    Treatment of autosomal dominant polycystic kidney disease

    Treatment of galactosialidosis, Treatment of GM1 gangliosidosis, Treatment of GM2 gangliosidosis, Treatment of sialidosis

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Enzyme Inhibitors

    Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

    Post Enquiry
    POST ENQUIRY