Vardenafil HCl

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ACTIVE PHARMA INGREDIENTS

41 API Suppliers, 6 USDMF, 5 CEP/COS, 2 JDMF, 3 EU WC, 2 KDMF, 23 NDC API, 23 Listed Suppliers, $ API Reference Price

DEVELOPMENTS

5 Drugs in Development

5 Drugs in Development

INTERMEDIATES

4 Intermediate Suppliers

4 Intermediate Suppliers

FINISHED DOSAGE FORMULATIONS

215 FDF Dossiers, 32 FDA Orange Book, 152 Europe, 6 Canada, 5 South Africa, 20 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET, ORALLY DISINTEGRATING;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 10MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 2.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 20MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

3 Rochem International Inc, 15 SPI Pharma, 5 DKSH, 4 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 ACG Worldwide, 3 Actylis, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 9 BASF, 10 Corel Pharma Chem, 2 DFE Pharma, 1 Esteem Industries, 1 Finar, 6 Gangwal Chemicals, 4 Ideal Cures, 1 Ingredion Pharma Solutions, 11 Kerry, 1 Keval Exports, 3 Kima Chemical, 6 Lonza Capsugel, 10 Microlex e.U, 2 Nitika Pharmaceutical Specialities, 2 Nomisma Healthcare, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 21 Roquette, 6 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 2 Shijiazhuang Huaxu Pharmaceutical, 8 Sigachi Industries, 2 Silverline Chemicals, 2 The Dow Chemical Company, 2 Vasa Pharmachem, 1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

41 Coating Systems & Additives, 41 Fillers, Diluents & Binders, 18 Direct Compression, 18 Controlled & Modified Release, 17 Taste Masking, 17 Thickeners and Stabilizers, 17 Chewable & Orodispersible Aids, 13 Film Formers & Plasticizers, 11 Granulation, 10 Lubricants & Glidants, 9 Co-Processed Excipients, 9 Disintegrants & Superdisintegrants, 8 Topical, 6 Parenteral, 6 Solubilizers, 5 Empty Capsules, 4 Vegetarian Capsules, 4 API Stability Enhancers, 4 Coloring Agents, 4 Emulsifying Agents, 4 Rheology Modifiers, 1 Soft Gelatin

DIGITAL CONTENT

19 News #PharmaBuzz

19 News #PharmaBuzz

GLOBAL SALES INFORMATION

5 US Medicaid Prescriptions, 26 Regulatory FDF Prices, 2 Annual Reports

MARKET PLACE

13 APIs

13 APIs

PATENTS & EXCLUSIVITIES

5 US Patents, 6 Health Canada Patents

REF. STANDARDS & IMPURITIES

13 Others

13 Others

ANALYTICAL

2 BioAnalytical Methods

2 BioAnalytical Methods

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Also known as:

Molecular Formula

C₂₃H₃₃ClN₆O₄S

Molecular Weight

525.1 g/mol

InChI Key

XCMULUAPJXCOHI-UHFFFAOYSA-N

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one;hydrochloride

2.1.2 InChI

InChI=1S/C23H32N6O4S.ClH/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28;/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30);1H

2.1.3 InChI Key

XCMULUAPJXCOHI-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl

2.1.5 Isomeric SMILES

CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl

2.2 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₃₃ClN₆O₄S
Molecular Weight	525.1 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	8
Exact Mass	524.1972524 g/mol
Monoisotopic Mass	524.1972524 g/mol
Topological Polar Surface Area	118 A^2
Heavy Atom Count	35
Formal Charge	0
Complexity	854
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Vardenafil hydrochloride
Drug Label	LEVITRA is an oral therapy for the treatment of erectile dysfunction. This monohydrochloride salt of vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Vardenafil HCl is designated...
Active Ingredient	Vardenafil hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 5mg; 10mg; 20mg
Market Status	Prescription
Company	Teva Pharms

2 of 2
Drug Name	Vardenafil hydrochloride
Drug Label	LEVITRA is an oral therapy for the treatment of erectile dysfunction. This monohydrochloride salt of vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Vardenafil HCl is designated...
Active Ingredient	Vardenafil hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	2.5mg; 5mg; 10mg; 20mg
Market Status	Prescription
Company	Teva Pharms

Vardenafil HCl

Vardenafil HCl

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

41 API Suppliers

6 USDMF

5 CEP/COS

2 JDMF

3 EU WC

2 KDMF

23 NDC API

23 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

5 Drugs in Development

INTERMEDIATES

4 Intermediate Suppliers

FINISHED DOSAGE FORMULATIONS

215 FDF Dossiers

32 FDA Orange Book

152 Europe

6 Canada

5 South Africa

20 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET, ORALLY DISINTEGRATING;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - EQ 10MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - EQ 2.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - EQ 20MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

3 Rochem International Inc

15 SPI Pharma

5 DKSH

4 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

1 Pfanstiehl

1 ACG Worldwide

3 Actylis

4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

9 BASF

10 Corel Pharma Chem

2 DFE Pharma

1 Esteem Industries

1 Finar

6 Gangwal Chemicals

4 Ideal Cures

1 Ingredion Pharma Solutions

11 Kerry

1 Keval Exports

3 Kima Chemical

6 Lonza Capsugel

10 Microlex e.U

2 Nitika Pharmaceutical Specialities

2 Nomisma Healthcare

1 Novo Excipients

1 Pharmatrans-Sanaq

2 Pluviaendo

2 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

21 Roquette

6 Seppic

4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

2 Shijiazhuang Huaxu Pharmaceutical

8 Sigachi Industries

2 Silverline Chemicals

2 The Dow Chemical Company

2 Vasa Pharmachem

1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

41 Coating Systems & Additives

41 Fillers, Diluents & Binders

18 Direct Compression

18 Controlled & Modified Release

17 Taste Masking

17 Thickeners and Stabilizers

TABLET, ORALLY DISINTEGRATING;ORAL - 10MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET;ORAL - EQ 10MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET;ORAL - EQ 2.5MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET;ORAL - EQ 20MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET;ORAL - EQ 5MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons