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Technical details about Vancomycin Hydrochloride, learn more about the structure, uses, toxicity, action, side effects and more

Vancomycin Hydrochloride

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

43 Suppliers, 20 USDMF, 16 CEP/COS, 8 JDMF, 1 EU WC, 13 KDMF, 21 NDC API, 21 Listed Suppliers

DEVELOPMENTS

13 Drug(s) in Development

13 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

DOSSIERs // Finished Dosage Forms

314 Dossiers, 140 FDA Orange Book, 72 Europe, 25 Canada, 10 Australia, 13 South Africa, 54 Listed Dossiers

DRUG PRODUCT COMPOSITION

POWDER;INTRAVENOUS - EQ 1.25GM BASE/VIAL, POWDER;INTRAVENOUS - EQ 1.5GM BASE/VIAL, POWDER;INTRAVENOUS - EQ 250MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, POWDER;INTRAVENOUS - EQ 750MG BASE/VIAL, POWDER;INTRAVENOUS, ORAL - EQ 10GM BASE/VIAL, POWDER;INTRAVENOUS, ORAL - EQ 1GM BASE/VIAL, POWDER;INTRAVENOUS, ORAL - EQ 500MG BASE/VIAL, POWDER;INTRAVENOUS, ORAL - EQ 5GM BASE/VIAL, CAPSULE;ORAL - EQ 125MG BASE, CAPSULE;ORAL - EQ 250MG BASE

RELATED EXCIPIENT COMPANIES

Suppliers, 14 BASF, 6 Actylis, 6 Roquette, 4 ACG Worldwide, 3 Lonza Capsugel, 2 Nomisma Healthcare, 2 Nanjing Well Pharmaceutical, 2 Seqens, 2 Gangwal Chemicals, 2 Finar, 1 Qualicaps, 1 Seppic

EXCIPIENTS BY APPLICATIONS

11 Topical, 8 Empty Capsules, 8 Parenteral, 7 Coating Systems & Additives, 6 Film Formers & Plasticizers, 5 Solubilizers, 5 Thickeners and Stabilizers, 5 Controlled & Modified Release, 3 Granulation, 3 Fillers, Diluents & Binders, 3 Taste Masking, 2 Lubricants & Glidants, 1 Direct Compression

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 65 Finished Drug Prices

MARKET PLACE

36 APIs, 20 DOSSIERS // FDF

PATENTS

60 US Patents, 4 US Exclusivities

REF. STANDARDS & IMPURITIES

1 Analytical Solutions, 1 EDQM, 2 USP, 4 Others

DIGITAL CONTENT

4 Data Compilation & Company Tracker #PharmaFlow, 92 News

1. Also known as: Vancomycin hydrochloride, Vancocin hcl, 1404-93-9, Vancomycin hydrochloride (extracted from streptomyces orientalis)

Molecular Formula

C₆₆H₇₆Cl₃N₉O₂₄

Molecular Weight

1485.7 g/mol

InChI Key

LCTORFDMHNKUSG-GXOKSPCMSA-N

Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1S,2R,18R,22S,25R,28R,40R)-48-[(2R,3S,4R,5R,6S)-3-[(2R,4R,5R,6R)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid;hydrochloride

2.1.2 InChI

InChI=1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34-,35+,42+,44-,46-,47-,48-,49?,50+,51-,52-,53+,54-,56+,57+,65-,66-;/m1./s1

2.1.3 InChI Key

LCTORFDMHNKUSG-GXOKSPCMSA-N

2.1.4 Canonical SMILES

CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl

2.1.5 Isomeric SMILES

C[C@@H]1[C@@H]([C@](C[C@H](O1)O[C@H]2[C@@H]([C@H]([C@@H](O[C@@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H](C(C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Ab-vancomycin

2. Diatracin

3. Hydrochloride, Vancomycin

4. Sulfate, Vancomycin

5. Vanco Azupharma

6. Vanco-cell

7. Vanco-saar

8. Vancocin

9. Vancocin Hcl

10. Vancocine

11. Vancomicina Abbott

12. Vancomicina Chiesi

13. Vancomicina Combino Phar

14. Vancomicina Norman

15. Vancomycin

16. Vancomycin Hexal

17. Vancomycin Hydrochloride

18. Vancomycin Lilly

19. Vancomycin Phosphate (1:2)

20. Vancomycin Phosphate (1:2), Decahydrate

21. Vancomycin Sulfate

22. Vancomycin-ratiopharm

23. Vancomycine Dakota

2.2.2 Depositor-Supplied Synonyms

1. Vancomycin Hydrochloride

2. Vancocin Hcl

3. 1404-93-9

4. Vancomycin Hydrochloride (extracted From Streptomyces Orientalis)

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₆₆H₇₆Cl₃N₉O₂₄
Molecular Weight	1485.7 g/mol
Hydrogen Bond Donor Count	20
Hydrogen Bond Acceptor Count	26
Rotatable Bond Count	13
Exact Mass	1483.406877 g/mol
Monoisotopic Mass	1483.406877 g/mol
Topological Polar Surface Area	531 Å²
Heavy Atom Count	102
Formal Charge	0
Complexity	2960
Isotope Atom Count	0
Defined Atom Stereocenter Count	17
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Vancocin hydrochloride
Active Ingredient	Vancomycin hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	eq 125mg base; eq 250mg base
Market Status	Prescription
Company	Ani Pharms

2 of 4
Drug Name	Vancomycin hydrochloride
Active Ingredient	Vancomycin hydrochloride
Dosage Form	Capsule; Injectable
Route	Injection; Oral
Strength	eq 750mg base/vial; eq 125mg base; eq 250mg base; eq 5gm base/vial; eq 500mg base/vial; eq 10gm base/vial; eq 1gm base/vial
Market Status	Prescription
Company	Hospira; Sandoz; Watson Labs; Strides Pharma; Emcure Pharms; Mustafa Nevzat Ilac; Fresenius Kabi Usa; Sagent Pharms; Agila Speclts; Akorn

3 of 4
Drug Name	Vancocin hydrochloride
Active Ingredient	Vancomycin hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	eq 125mg base; eq 250mg base
Market Status	Prescription
Company	Ani Pharms

4 of 4
Drug Name	Vancomycin hydrochloride
Active Ingredient	Vancomycin hydrochloride
Dosage Form	Capsule; Injectable
Route	Injection; Oral
Strength	eq 750mg base/vial; eq 125mg base; eq 250mg base; eq 5gm base/vial; eq 500mg base/vial; eq 10gm base/vial; eq 1gm base/vial
Market Status	Prescription
Company	Hospira; Sandoz; Watson Labs; Strides Pharma; Emcure Pharms; Mustafa Nevzat Ilac; Fresenius Kabi Usa; Sagent Pharms; Agila Speclts; Akorn

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

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