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    Technical details about Triprolidine Hcl, learn more about the structure, uses, toxicity, action, side effects and more

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    Triprolidine Hcl

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    DOSSIERs // Finished Dosage Forms

    MARKET PLACE

    PharmaCompass

    Inke S.A: APIs manufacturing plant.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    1. Also known as: Triprolidine hcl, 6138-79-0, Actidil, Myidyl, Triprolidine.hcl monohydrate, Trans-triprolidinehydrochloride
    Molecular Formula
    C19H25ClN2O
    Molecular Weight
    332.9  g/mol
    InChI Key
    CUZMOIXUFHOLLN-UMVVUDSKSA-N
    FDA UNII
    YAN7R5L890
    Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrate;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H22N2.ClH.H2O/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;;/h2-3,6-12H,4-5,13-15H2,1H3;1H;1H2/b18-11+;;
    2.1.3 InChI Key
    CUZMOIXUFHOLLN-UMVVUDSKSA-N
    2.1.4 Canonical SMILES
    CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3.O.Cl
    2.1.5 Isomeric SMILES
    CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3.O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    YAN7R5L890
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Actidil

    2. Anhydrous, Triprolidine Hydrochloride

    3. Hydrochloride Anhydrous, Triprolidine

    4. Hydrochloride, Triprolidine

    5. Pro Actidil

    6. Triprolidine

    7. Triprolidine Hydrochloride

    8. Triprolidine Hydrochloride Anhydrous

    9. Triprolidine Monohydrochloride

    10. Triprolidine Monohydrochloride, (z)-isomer

    11. Triprolidine Monohydrochloride, Monohydrate

    12. Triprolidine Oxalate

    13. Triprolidine Oxalate, (trans)-isomer

    14. Triprolidine, (z)-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. Triprolidine Hcl

    2. 6138-79-0

    3. Actidil

    4. Myidyl

    5. Triprolidine.hcl Monohydrate

    6. Trans-triprolidinehydrochloride

    7. Triprolidine Hydrochloride Hydrate

    8. Yan7r5l890

    9. Chebi:32265

    10. (e)-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine Monohydrochloride Monohydrate

    11. Nsc-757361

    12. Pro-actidil

    13. Pro-entra

    14. Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, Monohydrochloride, Monohydrate, (e)-

    15. 2-[(1e)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-en-1-yl]pyridine Hydrochloride Hydrate

    16. Triprolidine Hydrochloride Hydrate (jan)

    17. Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, Monohydrochloride, Monohydrate, (e)-

    18. Ccris 7215

    19. Triprolidine Hydrochloride Hydrate [jan]

    20. Triprolidine (hydrochloride Monohydrate)

    21. Unii-yan7r5l890

    22. Actidilon

    23. Triprolidine Hydrochloride [usp:jan]

    24. Venen (tn)

    25. Dsstox_cid_1410

    26. Dsstox_rid_76146

    27. Dsstox_gsid_21410

    28. Triprolidinehydrochloridehydrate

    29. Schembl1140974

    30. Chembl3188034

    31. Dtxsid0021410

    32. Triprolidine Hydrochloride (usp)

    33. Triprolidinhydrochlorid Monohydrat

    34. Hy-b1301

    35. Tox21_200848

    36. S5447

    37. Akos024370814

    38. Ccg-267838

    39. Nsc 757361

    40. W38t790

    41. (e)-2-(3-(pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine Hydrochloride Hydrate

    42. Ncgc00258402-01

    43. Bs-17733

    44. Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, Monohydrochloride, Monohydrate, Stereoisomer

    45. Triprolidine Hydrochloride [mart.]

    46. Triprolidine Hydrochloride [vandf]

    47. Cas-6138-79-0

    48. Triprolidine Hydrochloride [usp-rs]

    49. Cs-0013069

    50. D01782

    51. D70442

    52. Triprolidine Hydrochloride [orange Book]

    53. Myfed Component Triprolidine Hydrochloride

    54. Actifed Component Triprolidine Hydrochloride

    55. Corphed Component Triprolidine Hydrochloride

    56. Triphed Component Triprolidine Hydrochloride

    57. Triprolidine Hydrochloride [usp Monograph]

    58. Triprolidine Hydrochloride Monohydrate [mi]

    59. Actahist Component Triprolidine Hydrochloride

    60. Allerfed Component Triprolidine Hydrochloride

    61. Histafed Component Triprolidine Hydrochloride

    62. Trilitron Component Triprolidine Hydrochloride

    63. Triprolidine Hydrochloride Component Of Myfed

    64. Q27114841

    65. Triacin-c Component Triprolidine Hydrochloride

    66. Triprolidine Hydrochloride Component Of Actahist

    67. Triprolidine Hydrochloride Component Of Actifed

    68. Triprolidine Hydrochloride Component Of Allerfed

    69. Triprolidine Hydrochloride Component Of Corphed

    70. Triprolidine Hydrochloride Component Of Histafed

    71. Triprolidine Hydrochloride Component Of Triphed

    72. Triprolidine Hydrochloride Monohydrate [mart.]

    73. Triprolidine Hydrochloride Monohydrate [who-dd]

    74. Triprolidine Hydrochloride Component Of Triacin-c

    75. Triprolidine Hydrochloride Component Of Trilitron

    76. Triprolidine Hydrochloride Monohydrochloride Monohydrate

    77. (e)-2-[3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl]pyridine Hydrochloride Monohydrate

    78. 1-[(2e)-3-(4-methylphenyl)-3-(pyridin-2-yl)prop-2-en-1-yl]pyrrolidinium Chloride--water (1/1)

    79. 2-[(1e)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine Hydrochloride--water (1/1)

    2.4 Create Date
    2005-11-20
    3 Chemical and Physical Properties
    Molecular Weight 332.9 g/mol
    Molecular Formula C19H25ClN2O
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count4
    Exact Mass332.1655411 g/mol
    Monoisotopic Mass332.1655411 g/mol
    Topological Polar Surface Area17.1 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity336
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

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