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Technical details about Tox21_202801, learn more about the structure, uses, toxicity, action, side effects and more

Tox21_202801

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

18 Suppliers, 14 USDMF, 1 EU WC, 3 NDC API, 4 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports

DOSSIERs // Finished Dosage Forms

94 Dossiers, 94 FDA Orange Book

RELATED EXCIPIENT COMPANIES

Suppliers, 15 Kerry, 13 BASF, 10 Corel Pharma Chem, 10 Roquette, 9 Sigachi Industries, 8 Microlex e.U, 6 Lonza Capsugel, 6 Gangwal Chemicals, 6 Gangwal Healthcare, 6 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 6 Seppic, 5 Ideal Cures Pvt Ltd, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 3 Actylis, 3 DFE Pharma, 3 Kima Chemical, 3 Vasa Pharmachem, 3 Prachin Chemical, 2 The Dow Chemical Company, 2 Seqens, 2 Nomisma Healthcare, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Pharmatrans-Sanaq, 1 Finar, 1 Jai Radhe Sales, 1 Ingredion Pharma Solutions, 1 ACG Worldwide, 1 Qualicaps, 1 SPI Pharma

EXCIPIENTS BY APPLICATIONS

43 Coating Systems & Additives, 25 Controlled & Modified Release, 24 Fillers, Diluents & Binders, 16 Disintegrants & Superdisintegrants, 15 Thickeners and Stabilizers, 13 Direct Compression, 12 Lubricants & Glidants, 12 Granulation, 8 Topical, 7 Film Formers & Plasticizers, 6 Co-Processed Excipients, 6 Taste Masking, 5 Empty Capsules, 5 Solubilizers, 4 Vegetarian Capsules, 4 API Stability Enhancers, 3 Chewable & Orodispersible Aids, 3 Emulsifying Agents, 3 Rheology Modifiers, 2 Parenteral, 2 Coloring Agents

GLOBAL SALES INFORMATION

8 Finished Drug Prices

8 Finished Drug Prices

MARKET PLACE

1 APIs

1 APIs

ANALYTICAL SOLUTION(s)

1 Analytical Solutions, 1 USP Standards, 1 Other Ref. Standards

Tox21_202801
Chemistry
Full Screen View

Also known as: 130-61-0, Thioridazine hcl, Sonapax hydrochloride, Thioridazine chloride, Mellaril hydrochloride, Aldazine

Molecular Formula

C₂₁H₂₇ClN₂S₂

Molecular Weight

407.0 g/mol

InChI Key

NZFNXWQNBYZDAQ-UHFFFAOYSA-N

FDA UNII

4WCI67NK8M

A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride

2.1.2 InChI

InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H

2.1.3 InChI Key

NZFNXWQNBYZDAQ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC.Cl

2.2 Other Identifiers

2.2.1 UNII

4WCI67NK8M

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Aldazine

2. Apo Thioridazine

3. Apo-thioridazine

4. Apothioridazine

5. Meleril

6. Mellaril

7. Melleretten

8. Melleril

9. Melleryl

10. Melzine

11. Rideril

12. Sonapax

13. Thioridazine

14. Thioridazine Hcl

15. Thioridazine Neurazpharm

16. Thioridazine-neurazpharm

17. Thioridazineneurazpharm

18. Thiozine

2.3.2 Depositor-Supplied Synonyms

1. 130-61-0

2. Thioridazine Hcl

3. Sonapax Hydrochloride

4. Thioridazine Chloride

5. Mellaril Hydrochloride

6. Aldazine

7. Thioridazine (hydrochloride)

8. Usaf Sz-b

9. Usaf Sz-3

10. 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10h-phenothiazine Hydrochloride

11. Nsc-186060

12. 4wci67nk8m

13. Mls000028408

14. Chebi:48566

15. Orsanil

16. 10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine Monohydrochloride

17. 2-methylmercapto-10-(2-(n-methyl-2-piperidyl)ethyl)phenothiazine Hydrochloride

18. 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10h-phenothiazine Hydrochloride

19. 10h-phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-, Monohydrochloride

20. Smr000058380

21. Thioridazine.hcl

22. 10-(2-(1-methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine Hydrochloride

23. 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride

24. Melleril (tablet)

25. Melzine

26. 10h-phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, Monohydrochloride

27. 2-methylmercapto-10-[2-(n-methyl-2-piperidyl)ethyl]phenothiazine Hydrochloride

28. Nsc186060

29. Thioridazine Hydrochloride [jan]

30. Einecs 204-992-8

31. Unii-4wci67nk8m

32. Nsc 186060

33. Tioridazin

34. Metlaril

35. 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)-10h-phenothiazine Hydrochloride

36. Sr-01000000063

37. 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylthiophenothiazine Hydrochloride

38. 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylthio)-10h-phenothiazine Hydrochloride

39. Thioridazine Hydrochloride Intensol

40. Mellaril (tn)

41. Prestwick_437

42. Mfcd00012655

43. Thioridazine Hydrochloride [usp:jan]

44. Thoridazine Hydrochloride

45. Opera_id_1713

46. Cas-130-61-0

47. Dsstox_cid_29360

48. Dsstox_rid_83476

49. Dsstox_gsid_49401

50. Schembl41430

51. Mls001148599

52. Mls002222212

53. Spectrum1500575

54. Chembl1200916

55. Dtxsid9049401

56. Hms1568o17

57. Hms1921e11

58. Pharmakon1600-01500575

59. Bcp19941

60. Hy-b0965

61. Thioridazine Hydrochloride, >=99%

62. Tox21_202801

63. Tox21_501252

64. Ccg-39270

65. Nsc757349

66. S5563

67. Akos015994763

68. Cs-4450

69. Ks-5108

70. Lp01252

71. Nc00594

72. Nsc-757349

73. Thioridazine Hydrochloride (jp17/usp)

74. Thioridazine Hydrochloride [mi]

75. Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-, Monohydrochloride

76. Ncgc00094492-01

77. Ncgc00094492-02

78. Ncgc00094492-03

79. Ncgc00094492-04

80. Ncgc00094492-05

81. Ncgc00260347-01

82. Ncgc00261937-01

83. Thioridazine Hydrochloride [mart.]

84. Thioridazine Hydrochloride [vandf]

85. Thioridazine Hydrochloride [usp-rs]

86. Thioridazine Hydrochloride [who-dd]

87. Db-041975

88. Eu-0101252

89. Ft-0631759

90. Ft-0675189

91. Sw196660-3

92. T3102

93. D00798

94. D82085

95. T 9025

96. Thioridazine Hydrochloride [orange Book]

97. Thioridazine Hydrochloride [ep Monograph]

98. A806110

99. Thioridazine Hydrochloride [usp Monograph]

100. Sr-01000000063-2

101. Sr-01000000063-7

102. W-108347

103. Q27104616

104. Wln: T C666 Bn Isj Es1 B2-bt6ntj A1 & Gh

105. Z2784093622

106. Thioridazine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

107. Dopamine Receptor Antagonist Ii, Thioridazine, Hcl - Cas 130-61-0

108. Thioridazine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

109. 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-10h-phenothiazine Hydrochloride

110. Thioridazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₇ClN₂S₂
Molecular Weight	407.0 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	406.1304189 g/mol
Monoisotopic Mass	406.1304189 g/mol
Topological Polar Surface Area	57.1 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	432
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Thioridazine hydrochloride
Drug Label	Thioridazine hydrochloride is 2-methylmercapto-10-[2-(N-methyl-2-piperidyl) ethyl] phenothiazine. Its structural formula, molecular weight and molecular formula are:C21H26N2S2 HCl M.Wt.: 407.05Thioridazine hydrochlorid...
Active Ingredient	Thioridazine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	25mg; 100mg; 50mg; 10mg
Market Status	Prescription
Company	Mutual Pharm; Mylan

2 of 2
Drug Name	Thioridazine hydrochloride
Drug Label	Thioridazine hydrochloride is 2-methylmercapto-10-[2-(N-methyl-2-piperidyl) ethyl] phenothiazine. Its structural formula, molecular weight and molecular formula are:C21H26N2S2 HCl M.Wt.: 407.05Thioridazine hydrochlorid...
Active Ingredient	Thioridazine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	25mg; 100mg; 50mg; 10mg
Market Status	Prescription
Company	Mutual Pharm; Mylan

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Phenothiazines [CS]; Phenothiazine [EPC]

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