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    Technical details about Tirofiban, learn more about the structure, uses, toxicity, action, side effects and more

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    Tirofiban

    APIs // Active Pharmaceutical Ingredients

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    2D Structure
    1. Also known as: Tirofiban hydrochloride, 142373-60-2, Tirofiban hcl, Tirofiban (hydrochloride), Tirofiban hydrochloride anhydrous, Ike1p4x57j
    Molecular Formula
    C22H37ClN2O5S
    Molecular Weight
    477.1  g/mol
    InChI Key
    KPKFFYOMPGOQRP-BOXHHOBZSA-N
    FDA UNII
    IKE1P4X57J
    Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid;hydrochloride
    2.1.2 InChI
    InChI=1S/C22H36N2O5S.ClH/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18;/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26);1H/t21-;/m0./s1
    2.1.3 InChI Key
    KPKFFYOMPGOQRP-BOXHHOBZSA-N
    2.1.4 Canonical SMILES
    CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O.Cl
    2.1.5 Isomeric SMILES
    CCCCS(=O)(=O)N[C@@H](CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    IKE1P4X57J
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Agrastat

    2. L 700,462

    3. L 700462

    4. L-700,462

    5. L-700462

    6. L700,462

    7. Mk 383

    8. Mk-383

    9. N-(butylsulfonyl)-o-(4-(4-piperidyl)butyl)-l-tyrosine

    10. Tirofiban

    11. Tirofiban Hydrochloride

    12. Tirofiban Hydrochloride Monohydrate

    2.3.2 Depositor-Supplied Synonyms

    1. Tirofiban Hydrochloride

    2. 142373-60-2

    3. Tirofiban Hcl

    4. Tirofiban (hydrochloride)

    5. Tirofiban Hydrochloride Anhydrous

    6. Ike1p4x57j

    7. (s)-2-(butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic Acid Hydrochloride

    8. Mk 383

    9. L 700462

    10. 142373-60-2 (hcl)

    11. L-tyrosine, N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-, Monohydrochloride

    12. Tirofibanhydrochloridemonohydrate

    13. N-(butylsulfonyl)-o-[4-(4-piperidinyl)butyl]-l-tyrosine Hydrochloride

    14. L-700462

    15. Mk-383

    16. Unii-ike1p4x57j

    17. N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-l-tyrosine Monohydrochloride

    18. Chembl1704

    19. Schembl41327

    20. Dtxsid70931418

    21. 2-(butylsulfonylamino)-3-[4-[4-(4-piperidinyl)butoxy]phenyl]propanoic Acid Hydrochloride

    22. Amy23379

    23. Ex-a2875

    24. Hy-17369a

    25. Mfcd00868210

    26. Akos025311245

    27. Tirofiban Hydrochloride [who-dd]

    28. Cs-0009551

    29. T3640

    30. Tirofiban Hydrochloride Anhydrous [mi]

    31. 915t405

    32. Q27280770

    33. (s)-2-(butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoicacidhydrochloride

    34. L-tyrosine, N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-, Hydrochloride (1:1)

    35. N-(butane-1-sulfonyl)-o-[4-(piperidin-4-yl)butyl]tyrosine--hydrogen Chloride (1/1)

    36. (2s)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic Acid;hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 477.1 g/mol
    Molecular Formula C22H37ClN2O5S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count14
    Exact Mass476.2111712 g/mol
    Monoisotopic Mass476.2111712 g/mol
    Topological Polar Surface Area113 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity579
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Fibrinolytic Agents

    Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)

    Platelet Aggregation Inhibitors

    Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

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