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    Technical details about Tezampanel, learn more about the structure, uses, toxicity, action, side effects and more

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    Tezampanel

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    2D Structure
    1. Also known as: 154652-83-2, Tezampanel (anhydrous), Ly-293558, Ly293558, 150131-78-5, Tezampanel [inn]
    Molecular Formula
    C13H21N5O2
    Molecular Weight
    279.34  g/mol
    InChI Key
    ZXFRFPSZAKNPQQ-YTWAJWBKSA-N
    FDA UNII
    GA36S2O9C2
    Tezampanel is an AMPA receptor antagonist.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (3S,4aR,6R,8aR)-6-[2-(2H-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid
    2.1.2 InChI
    InChI=1S/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11+/m1/s1
    2.1.3 InChI Key
    ZXFRFPSZAKNPQQ-YTWAJWBKSA-N
    2.1.4 Canonical SMILES
    C1CC2CNC(CC2CC1CCC3=NNN=N3)C(=O)O
    2.1.5 Isomeric SMILES
    C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CCC3=NNN=N3)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    GA36S2O9C2
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (3s,4ar,6r,8ar)-6-(2-(1(2)h-tetrazole-5yl)ethyl)decahydroisoquinoline-3carboxylic Acid

    2. 6-(2-(1h-tetrazol-5-yl)ethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic Acid

    3. Ly 215490

    4. Ly 293558

    5. Ly 326325

    6. Ly-215490

    7. Ly-293558

    8. Ly-326325

    9. Ly293558

    10. Ngx424

    2.3.2 Depositor-Supplied Synonyms

    1. 154652-83-2

    2. Tezampanel (anhydrous)

    3. Ly-293558

    4. Ly293558

    5. 150131-78-5

    6. Tezampanel [inn]

    7. Tezampanel, Anhydrous

    8. Ly 293558

    9. Ngx-424

    10. Ly-293,558

    11. 6-(2-(1h-tetrazol-5-yl)ethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic Acid

    12. Chembl14935

    13. Ga36s2o9c2

    14. (3s,4ar,6r,8ar)-6-[2-(2h-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic Acid

    15. 154652-83-2 (anhydrous)

    16. (3s,4ar,6r,8ar)-6-(2-(1h-tetrazol-5-yl)ethyl)decahydroisoquinoline-3-carboxylic Acid

    17. Ted-isoquinoline-3-cooh

    18. Unii-ga36s2o9c2

    19. Ly215490

    20. Decahydro-6-(2-(1h-tetrazol-5-yl)ethyl)-3-isoquinolinecarboxylic Acid

    21. Tezampanel Anhydrous

    22. Gtpl4245

    23. Schembl1649338

    24. Bdbm86751

    25. Zinc5134714

    26. Bdbm50494341

    27. Cs-0821

    28. Db06354

    29. 3-isoquinolinecarboxylic Acid, Decahydro-6-(2-(1h-tetrazol-5-yl)ethyl)-, (3s,4ar,6r,8ar)-

    30. Ncgc00378884-01

    31. 3-isoquinolinecarboxylic Acid, Decahydro-6-(2-(1h-tetrazol-5-yl)ethyl)-, (3s-(3alpha,4aalpha,6beta,8aalpha))-

    32. Hy-75704

    33. Q7708612

    34. (3s,4ar,6r,8ar)-6-[2-(1h-1,2,3,4-tetrazol-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic Acid

    35. (3s,4ar,6r,8ar)-6-[2-(2h-1,2,3,4-tetrazol-5-yl)ethyl]-decahydroisoquinoline-3-carboxylic Acid

    36. (3s,4as,6r,8as)-6-(2-(1h-tetrazol-5-yl)ethyl)decahydroisoquinoline-3-carboxylic Acid

    37. 3-isoquinolinecarboxylic Acid, Decahydro-6-(2-(1h-tetrazol-5-yl)ethyl)-, (3s,4as,6r,8as)-

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 279.34 g/mol
    Molecular Formula C13H21N5O2
    XLogP3-0.8
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count4
    Exact Mass279.16952493 g/mol
    Monoisotopic Mass279.16952493 g/mol
    Topological Polar Surface Area104 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity354
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for use/treatment in pain (acute or chronic) and migraine and cluster headaches.

    5 Pharmacology and Biochemistry
    5.1 Mechanism of Action

    NGX426 is a prodrug of tezampanel (NGX424). Tezampanel is an antagonist that binds to glutamate kainate (Glu K5) receptors, inhibiting excitatory synapases the brain.

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